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    Tp63 tumor protein p63 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 246334, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tp63provided by RGD
    Official Full Name
    tumor protein p63provided by RGD
    Primary source
    RGD:620863
    See related
    EnsemblRapid:ENSRNOG00000001924 AllianceGenome:RGD:620863
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ket; P73l; Tp73l; Trp63
    Summary
    This gene encodes tumor protein p63, a member of the p53 family of transcription factors involved in cellular responses to stress and development. The family members include p53, p63, and p73, which have high sequence similarity to one another. This similarity allows p63 and p73 to transactivate p53-responsive genes causing cell cycle arrest and apoptosis. The family members can interact with each other in many ways, including direct and indirect protein interactions. This results in mutual regulation of target gene promoters. Both alternative splicing and the use of alternative promoters result in multiple transcript variants encoding different protein isoforms.[provided by RefSeq, Dec 2009]
    Expression
    Biased expression in Thymus (RPKM 17.0), Muscle (RPKM 14.0) and 1 other tissue See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Tp63 in Genome Data Viewer
    Location:
    11q22
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (88343647..88554543, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (74838858..75049764, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (78234853..78456559, complement)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene activator of basal transcription 1, pseudogene 1 Neighboring gene macrophage-capping protein pseudogene Neighboring gene prolyl 3-hydroxylase 2 Neighboring gene RNA transcription, translation and transport factor, pseudogene 1 Neighboring gene heterogeneous nuclear ribonucleoprotein H2-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables MDM2/MDM4 family protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables WW domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables damaged DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables p53 binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables promoter-specific chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
     
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of Notch signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within anatomical structure formation involved in morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within animal organ morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cellular senescence ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cloacal septation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cranial skeletal system development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within determination of adult lifespan ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within ectoderm and mesoderm interaction ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within embryonic forelimb morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within embryonic hindlimb morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within embryonic limb morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within epidermal cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within epidermal cell division ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within epidermis development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within epithelial cell development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within epithelial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within establishment of planar polarity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in establishment of skin barrier ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in establishment of skin barrier ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within female genitalia morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within hair follicle development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within hair follicle morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within keratinocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of keratinocyte proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within morphogenesis of a polarized epithelium ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cellular senescence ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of intracellular estrogen receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of keratinocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of mesoderm development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within odontogenesis of dentin-containing tooth ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within pattern specification process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within polarized epithelial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of Notch signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of Notch signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell cycle G1/S phase transition ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of fibroblast apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of keratinocyte proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of somatic stem cell population maintenance ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of stem cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within post-anal tail morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within prostate gland development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within prostatic bud formation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein tetramerization IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within proximal/distal pattern formation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of epidermal cell division ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of epidermal cell division ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within skeletal system development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within skin epidermis development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within skin morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in spermatogenesis IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within squamous basal epithelial stem cell differentiation involved in prostate gland acinus development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within stem cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of stem cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within stem cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within sympathetic nervous system development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    tumor protein 63
    Names
    keratinocyte transcription factor KET
    transformation related protein 63
    tumor protein 63 kDa

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001127339.2NP_001120811.1  tumor protein 63 isoform b

      See identical proteins and their annotated locations for NP_001120811.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an internal exon in the 3' region, as compared to variant 1. The resulting isoform (b, also known as TA2KETbeta) has a shorter and different C-terminus, as compared to isoform a.
      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/Swiss-Prot
      Q9JJP6
      Related
      ENSRNOP00000059178.3, ENSRNOT00000067251.6
      Conserved Domains (3) summary
      pfam08430
      Location:452534
      Forkhead_N; Forkhead N-terminal region
      pfam00870
      Location:163358
      P53; P53 DNA-binding domain
      pfam07710
      Location:391431
      P53_tetramer; P53 tetramerization motif
    2. NM_001127341.1NP_001120813.1  tumor protein 63 isoform c

      See identical proteins and their annotated locations for NP_001120813.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks several 3' exons but has an alternate 3' exon, as compared to variant 1. The resulting isoform (c, also known as TA2KETgamma) has a shorter and different C-terminus, as compared to isoform a.
      Source sequence(s)
      AJ277449, Y10258
      UniProtKB/TrEMBL
      A6JRZ6
      Related
      ENSRNOP00000032308.4, ENSRNOT00000036179.7
      Conserved Domains (2) summary
      cd08367
      Location:177358
      P53; P53 DNA-binding domain
      pfam07710
      Location:392428
      P53_tetramer; P53 tetramerisation motif
    3. NM_001127342.3NP_001120814.1  tumor protein 63 isoform d

      See identical proteins and their annotated locations for NP_001120814.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) is an alternate promoter product; it lacks several 5' exons but has an alternate 5' exon, as compared to variant 1. The resulting isoform (d, also known as deltaNKETalpha) has a shorter and different N-terminus, as compared to isoform a.
      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/TrEMBL
      A6JRZ5
      Related
      ENSRNOP00000002636.4, ENSRNOT00000002636.9
      Conserved Domains (5) summary
      cd09572
      Location:449513
      SAM_tumor-p63; SAM domain of tumor-p63 proteins
      smart00454
      Location:447512
      SAM; Sterile alpha motif
      pfam08430
      Location:358440
      Forkhead_N; Forkhead N-terminal region
      pfam00870
      Location:69264
      P53; P53 DNA-binding domain
      pfam07710
      Location:297337
      P53_tetramer; P53 tetramerization motif
    4. NM_001127343.3NP_001120815.1  tumor protein 63 isoform e

      See identical proteins and their annotated locations for NP_001120815.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) is an alternate promoter product; it lacks several 5' exons and an internal exon in the 3' region, but has an alternate 5' exon, as compared to variant 1. The resulting isoform (e, also known as deltaNKETbeta) has shorter and different N- and C-termini, as compared to isoform a.
      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/Swiss-Prot
      Q9JJP6
      Conserved Domains (2) summary
      pfam00870
      Location:69264
      P53; P53 DNA-binding domain
      pfam07710
      Location:297337
      P53_tetramer; P53 tetramerization motif
    5. NM_001127344.2NP_001120816.1  tumor protein 63 isoform f

      See identical proteins and their annotated locations for NP_001120816.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) is an alternate promoter product; it lacks several 5' and 3' exons, but has alternate 5' and 3' exons, as compared to variant 1. The resulting isoform (f, also known as deltaNKETgamma) has shorter and different N- and C-termini, as compared to isoform a.
      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/TrEMBL
      A6JRZ7
      Conserved Domains (2) summary
      pfam00870
      Location:69264
      P53; P53 DNA-binding domain
      pfam07710
      Location:297337
      P53_tetramer; P53 tetramerization motif
    6. NM_019221.4NP_062094.1  tumor protein 63 isoform a

      See identical proteins and their annotated locations for NP_062094.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a, also known as TA2KETalpha).
      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/Swiss-Prot
      Q99JD6, Q99JD7, Q99JD8, Q99JD9, Q99JE0, Q99JE1, Q99JE2, Q99JE3, Q9JJP6
      UniProtKB/TrEMBL
      A6JRZ4
      Related
      ENSRNOP00000061884.4, ENSRNOT00000068116.6
      Conserved Domains (3) summary
      cd08367
      Location:177358
      P53; P53 DNA-binding domain
      cd09572
      Location:543607
      SAM_tumor-p63; SAM domain of tumor-p63 proteins
      pfam07710
      Location:392428
      P53_tetramer; P53 tetramerisation motif

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      88343647..88554543 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017597881.3XP_017453370.1  tumor protein 63 isoform X1

    2. XM_063270286.1XP_063126356.1  tumor protein 63 isoform X2

    3. XM_063270287.1XP_063126357.1  tumor protein 63 isoform X3

    4. XM_006248500.5XP_006248562.1  tumor protein 63 isoform X4

      Conserved Domains (2) summary
      cd08367
      Location:177358
      P53; P53 DNA-binding domain
      pfam07710
      Location:388424
      P53_tetramer; P53 tetramerisation motif
    5. XM_063270288.1XP_063126358.1  tumor protein 63 isoform X5