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    Cetn2 centrin 2 [ Mus musculus (house mouse) ]

    Gene ID: 26370, updated on 4-Jan-2025

    Summary

    Official Symbol
    Cetn2provided by MGI
    Official Full Name
    centrin 2provided by MGI
    Primary source
    MGI:MGI:1347085
    See related
    Ensembl:ENSMUSG00000031347 AllianceGenome:MGI:1347085
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Calt; caltractin; 1110034A02Rik
    Summary
    Enables G-protein beta/gamma-subunit complex binding activity; heterotrimeric G-protein binding activity; and microtubule binding activity. Involved in spermatogenesis. Located in several cellular components, including glial cell projection; microtubule organizing center; and photoreceptor connecting cilium. Is expressed in 4th ventricle lateral recess; choroid plexus; and lateral ventricle choroid plexus. Orthologous to human CETN2 (centrin 2). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Broad expression in CNS E11.5 (RPKM 20.4), bladder adult (RPKM 16.1) and 22 other tissues See more
    Orthologs
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    Genomic context

    See Cetn2 in Genome Data Viewer
    Location:
    X A7.3; X 37.29 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (71957137..71961967, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (72913565..72918344, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene gamma-aminobutyric acid type A receptor subunit theta Neighboring gene MAGE family member A9, pseudogene Neighboring gene NAD(P) dependent steroid dehydrogenase-like Neighboring gene zinc finger protein 185 Neighboring gene microRNA 2137

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in cell division  
    involved_in centriole replication  
    involved_in centriole replication  
    involved_in centriole replication  
    involved_in mRNA transport  
    involved_in microtubule cytoskeleton organization  
    involved_in nucleotide-excision repair  
    involved_in nucleotide-excision repair  
    involved_in nucleotide-excision repair  
    involved_in protein transport  
    involved_in regulation of cytokinesis  
    involved_in regulation of cytokinesis  
    involved_in spermatogenesis PubMed 
    Component Evidence Code Pubs
    located_in 9+2 motile cilium PubMed 
    part_of XPC complex  
    part_of XPC complex  
    located_in apical part of cell PubMed 
    is_active_in centriole  
    located_in centriole PubMed 
    located_in centriole PubMed 
    is_active_in centrosome  
    located_in centrosome PubMed 
    located_in centrosome  
    located_in ciliary basal body PubMed 
    located_in cilium PubMed 
    located_in cytoplasm  
    located_in glial cell projection PubMed 
    part_of nuclear pore nuclear basket  
    part_of nuclear pore nuclear basket  
    is_active_in nucleus  
    located_in photoreceptor connecting cilium PubMed 
    part_of transcription export complex 2  
    part_of transcription export complex 2  

    General protein information

    Preferred Names
    centrin-2
    Names
    caltractin, 20 kDa calcium binding protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019405.7NP_062278.2  centrin-2

      See identical proteins and their annotated locations for NP_062278.2

      Status: VALIDATED

      Source sequence(s)
      AL671908
      Consensus CDS
      CCDS41003.1
      UniProtKB/Swiss-Prot
      B1AUQ6, B1AUQ8, Q3UBB4, Q9CWM0, Q9R1K9
      UniProtKB/TrEMBL
      Z4YJH1
      Related
      ENSMUSP00000110198.4, ENSMUST00000114551.10
      Conserved Domains (2) summary
      PTZ00183
      Location:16172
      PTZ00183; centrin; Provisional
      cd00051
      Location:105167
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      71957137..71961967 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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