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    colt congested-like trachea [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33470, updated on 9-Dec-2024

    Summary

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    Official Symbol
    coltprovided by FlyBase
    Official Full Name
    congested-like tracheaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0019830
    Locus tag
    Dmel_CG3057
    See related
    AllianceGenome:FB:FBgn0019830
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CACT; CG3057; Colt; Dmel\CG3057
    Summary
    Predicted to enable acyl carnitine transmembrane transporter activity. Involved in epithelial cell morphogenesis and liquid clearance, open tracheal system. Predicted to be located in membrane. Predicted to be active in mitochondrial envelope. Is expressed in adult head; adult heart; and spermatozoon. Human ortholog(s) of this gene implicated in carnitine-acylcarnitine translocase deficiency. Orthologous to human SLC25A20 (solute carrier family 25 member 20). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See colt in Genome Data Viewer
    Location:
    23A5-23A5; 2-7 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (2768590..2770069, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (2768590..2770069, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene anterior pharynx defective 1 Neighboring gene TBP-associated factor 10b Neighboring gene TBP-associated factor 10 Neighboring gene uncharacterized protein Neighboring gene histidine triad nucleotide binding protein 1 Neighboring gene Synaptotagmin 1 Neighboring gene long non-coding RNA:CR43821

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Medium-Chain Fatty Acids, Beta-Hydroxybutyric Acid and Genetic Modulation of the Carnitine Shuttle Are Protective in a Drosophila Model of ALS Based on TDP-43. Manzo E, et al. Front Mol Neurosci, 2018. PMID 29904341, Free PMC Article
    2. A novel Drosophila mitochondrial carrier protein acts as a Mg(2+) exporter in fine-tuning mitochondrial Mg(2+) homeostasis. Cui Y, et al. Biochim Biophys Acta, 2016 Jan. PMID 26462626
    3. The Reversible Carnitine Palmitoyltransferase 1 Inhibitor (Teglicar) Ameliorates the Neurodegenerative Phenotype in a Drosophila Huntington's Disease Model by Acting on the Expression of Carnitine-Related Genes. Bertapelle C, et al. Molecules, 2022 May 13. PMID 35630602, Free PMC Article
    4. The congested-like tracheae gene of Drosophila melanogaster encodes a member of the mitochondrial carrier family required for gas-filling of the tracheal system and expansion of the wings after eclosion. Hartenstein K, et al. Genetics, 1997 Dec. PMID 9409834, Free PMC Article
    5. Two novel Drosophila TAF(II)s have homology with human TAF(II)30 and are differentially regulated during development. Georgieva S, et al. Mol Cell Biol, 2000 Mar. PMID 10669741, Free PMC Article

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables acyl carnitine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in carnitine transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in epithelial cell morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in liquid clearance, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrial transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    is_active_in mitochondrial envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    congested-like trachea
    Names
    CG3057-PA
    CG3057-PD
    carnitine Acyl-Carnitine translocase
    collapsed trachea
    colt-PA
    colt-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      2768590..2770069 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057873.5 → NP_477221.1  congested-like trachea, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477221.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V020, O01396, Q9VQG4
      Related
      FBpp0077414
      Conserved Domains (1) summary
      pfam00153
      Location:12 → 107
      Mito_carr; Mitochondrial carrier protein

    2. NM_205894.1 → NP_995616.1  congested-like trachea, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995616.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V020, O01396, Q9VQG4
      Conserved Domains (1) summary
      pfam00153
      Location:12 → 107
      Mito_carr; Mitochondrial carrier protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VQG4.1 Q9VQG4

    Gene LinkOut

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