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    Tig Tiggrin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33896, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tigprovided by FlyBase
    Official Full Name
    Tiggrinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0011722
    Locus tag
    Dmel_CG11527
    See related
    AllianceGenome:FB:FBgn0011722
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11527; CT36389; Dmel\CG11527; tig; TIG
    Summary
    Enables integrin binding activity. Involved in several processes, including cell adhesion mediated by integrin; photoreceptor cell axon guidance; and substrate adhesion-dependent cell spreading. Located in basement membrane. Is expressed in several structures, including adult head; adult heart; embryonic/larval hemolymph; fat body; and mesothoracic tergotrochanter muscle cell. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Tig in Genome Data Viewer
    Location:
    26D1-26D1; 2-20 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6415179..6423310, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6415179..6423310, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Dpr-interacting protein epsilon Neighboring gene Neprilysin-like 6 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Fic domain-containing protein Neighboring gene Acyl-CoA oxidase 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Amino acid changes in Drosophila alphaPS2betaPS integrins that affect ligand affinity. Bunch TA, et al. J Biol Chem, 2006 Feb 24. PMID 16371365
    2. Disruption of C-terminal cytoplasmic domain of betaPS integrin subunit has dominant negative properties in developing Drosophila. Jannuzi AL, et al. Mol Biol Cell, 2002 Apr. PMID 11950944, Free PMC Article
    3. Tiggrin, a novel Drosophila extracellular matrix protein that functions as a ligand for Drosophila alpha PS2 beta PS integrins. Fogerty FJ, et al. Development, 1994 Jul. PMID 7924982
    4. The matrix protein Tiggrin regulates plasmatocyte maturation in Drosophila larva. Zhang CU, et al. Development, 2017 Jul 1. PMID 28526755, Free PMC Article
    5. Screening for Drosophila proteins with distinct expression patterns during development by use of monoclonal antibodies. Kumagai T, et al. Biosci Biotechnol Biochem, 2000 Jan. PMID 10705444

    See all (117) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Wee1 inhibits plasmatocyte maturation through upregulation of Tiggrin transcription.
      Title: The matrix protein Tiggrin regulates plasmatocyte maturation in Drosophila larva.
    2. the glycosyltransferase, pgant3, specifically modulates integrin-mediated cell adhesion by influencing the secretion and localization of the integrin ligand, Tiggrin
      Title: An O-glycosyltransferase promotes cell adhesion during development by influencing secretion of an extracellular matrix integrin ligand.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables integrin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell adhesion mediated by integrin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cell-substrate adhesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in photoreceptor cell axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell adhesion mediated by integrin IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in substrate adhesion-dependent cell spreading IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in basement membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tiggrin
    Names
    CG11527-PA
    CG11527-PB
    Tig-PA
    Tig-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      6415179..6423310 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298741.1 → NP_001285670.1  tiggrin, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285670.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q23984, Q6NR23, Q9VMD9
      UniProtKB/TrEMBL
      X2JDD7
      Conserved Domains (2) summary
      COG1196
      Location:1021 → 1370
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15921
      Location:416 → 1194
      CCDC158; Coiled-coil domain-containing protein 158

    2. NM_057685.4 → NP_477033.1  tiggrin, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477033.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q23984, Q6NR23, Q9VMD9
      UniProtKB/TrEMBL
      X2JDD7
      Related
      FBpp0078905
      Conserved Domains (2) summary
      COG1196
      Location:1021 → 1370
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15921
      Location:416 → 1194
      CCDC158; Coiled-coil domain-containing protein 158
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VMD9.2 Q9VMD9
    X2JDD7 X2JDD7

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