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    MED2 Med2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851559, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MED2
    Official Full Name
    Med2p
    Primary source
    SGD:S000002163
    Locus tag
    YDL005C
    See related
    AllianceGenome:SGD:S000002163; FungiDB:YDL005C; VEuPathDB:YDL005C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables RNA polymerase II-specific DNA-binding transcription factor binding activity and transcription coactivator activity. Involved in RNA polymerase II preinitiation complex assembly; negative regulation of transcription by RNA polymerase II; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within replicative senescence and response to endoplasmic reticulum stress. Located in cytosol and nucleus. Part of core mediator complex and mediator complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MED2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (441014..442309, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene proteasome regulatory particle base subunit RPT2 Neighboring gene type 2C protein phosphatase PTC1 Neighboring gene F1F0 ATP synthase subunit delta Neighboring gene kleisin alpha

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Proteolytic instability and the action of nonclassical transcriptional activators. Wang X, et al. Curr Biol, 2010 May 11. PMID 20417106, Free PMC Article
    2. A triad of subunits from the Gal11/tail domain of Srb mediator is an in vivo target of transcriptional activator Gcn4p. Zhang F, et al. Mol Cell Biol, 2004 Aug. PMID 15254252, Free PMC Article
    3. Mediator, SWI/SNF and SAGA complexes regulate Yap8-dependent transcriptional activation of ACR2 in response to arsenate. Menezes RA, et al. Biochim Biophys Acta Gene Regul Mech, 2017 Apr. PMID 28188921
    4. Site-specific Srb10-dependent phosphorylation of the yeast Mediator subunit Med2 regulates gene expression from the 2-microm plasmid. Hallberg M, et al. Proc Natl Acad Sci U S A, 2004 Mar 9. PMID 14988503, Free PMC Article
    5. Mediator protein mutations that selectively abolish activated transcription. Myers LC, et al. Proc Natl Acad Sci U S A, 1999 Jan 5. PMID 9874773, Free PMC Article

    See all (98) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription coactivator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA polymerase II preinitiation complex assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within replicative senescence IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to endoplasmic reticulum stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of core mediator complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of mediator complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Med2p
    NP_010279.3
    • Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; relocalizes to the cytosol in response to hypoxia

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      441014..442309 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180064.3 → NP_010279.3  TPA: Med2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010279.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRY3, Q12124
      UniProtKB/TrEMBL
      A6ZXW1, B3LGR3, N1P693
      Conserved Domains (1) summary
      pfam11214
      Location:27 → 141
      Med2; Mediator complex subunit 2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12124.1

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