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    RSO55 Rso55p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850987, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RSO55
    Official Full Name
    Rso55p
    Primary source
    SGD:S000004271
    Locus tag
    YLR281C
    See related
    AllianceGenome:SGD:S000004271; FungiDB:YLR281C; VEuPathDB:YLR281C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    PTH3
    Summary
    Enables aminoacyl-tRNA hydrolase activity. Involved in mitochondrial translation. Is active in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 7 and hereditary spastic paraplegia 55. Orthologous to human MTRFR (mitochondrial translation release factor in rescue). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See RSO55 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (704493..704960, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene cleavage polyadenylation factor subunit YSH1 Neighboring gene uncharacterized protein Neighboring gene Put7p Neighboring gene dodecenoyl-CoA isomerase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A stalled-ribosome rescue factor Pth3 is required for mitochondrial translation against antibiotics in Saccharomyces cerevisiae. Hoshino S, et al. Commun Biol, 2021 Mar 8. PMID 33686140, Free PMC Article
    2. Assessing systems properties of yeast mitochondria through an interaction map of the organelle. Perocchi F, et al. PLoS Genet, 2006 Oct 20. PMID 17054397, Free PMC Article
    3. Definition of a High-Confidence Mitochondrial Proteome at Quantitative Scale. Morgenstern M, et al. Cell Rep, 2017 Jun 27. PMID 28658629, Free PMC Article
    4. Genome-wide protein interaction screens reveal functional networks involving Sm-like proteins. Fromont-Racine M, et al. Yeast, 2000 Jun 30. PMID 10900456, Free PMC Article
    5. Molecular Connectivity of Mitochondrial Gene Expression and OXPHOS Biogenesis. Singh AP, et al. Mol Cell, 2020 Sep 17. PMID 32877643

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables aminoacyl-tRNA hydrolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables translation release factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in translational termination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Rso55p
    NP_013383.1
    • Stalled-ribosome rescue factor srRF2; mitochondrial protein required for respiratory growth in presence of bacteriostatic ribosome-binding antibiotics; not an essential gene

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      704493..704960 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182168.1 → NP_013383.1  TPA: Rso55p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013383.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VYS6, Q05863
      UniProtKB/TrEMBL
      A7A1G3, B3RHG1, C7GVT1, C8ZDP4, N1NZY2
      Conserved Domains (1) summary
      COG1186
      Location:1 → 152
      PrfB; Protein chain release factor B [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q05863.1

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