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    IBA57 Iba57p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853586, updated on 9-Dec-2024

    Summary

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    Official Symbol
    IBA57
    Official Full Name
    Iba57p
    Primary source
    SGD:S000003883
    Locus tag
    YJR122W
    See related
    AllianceGenome:SGD:S000003883; FungiDB:YJR122W; VEuPathDB:YJR122W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    CAF17
    Summary
    Predicted to enable transferase activity. Involved in protein maturation by [2Fe-2S] cluster transfer and protein maturation by [4Fe-4S] cluster transfer. Located in mitochondrial matrix. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 74 and multiple mitochondrial dysfunctions syndrome 3. Orthologous to human IBA57 (iron-sulfur cluster assembly factor IBA57). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See IBA57 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (649776..651269)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Dmo1p Neighboring gene F1F0 ATP synthase subunit beta Neighboring gene ribosomal 40S subunit protein S5 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Data on the role of iba57p in free Fe(2+) release and O(2)(∙-) generation in Saccharomyces cerevisiae. Gomez-Gallardo M, et al. Data Brief, 2018 Jun. PMID 29900191, Free PMC Article
    2. Iba57p participates in maturation of a [2Fe-2S]-cluster Rieske protein and in formation of supercomplexes III/IV of Saccharomyces cerevisiae electron transport chain. Sánchez LA, et al. Mitochondrion, 2019 Jan. PMID 29343425
    3. Mitochondrial Iba57p is required for Fe/S cluster formation on aconitase and activation of radical SAM enzymes. Gelling C, et al. Mol Cell Biol, 2008 Mar. PMID 18086897, Free PMC Article
    4. Reactive oxygen species production induced by ethanol in Saccharomyces cerevisiae increases because of a dysfunctional mitochondrial iron-sulfur cluster assembly system. Pérez-Gallardo RV, et al. FEMS Yeast Res, 2013 Dec. PMID 24028658
    5. Systematic mutagenesis of the leucine-rich repeat (LRR) domain of CCR4 reveals specific sites for binding to CAF1 and a separate critical role for the LRR in CCR4 deadenylase activity. Clark LB, et al. J Biol Chem, 2004 Apr 2. PMID 14734555

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These findings suggest that Iba57p participates in maturation of the [2Fe-2S]-cluster into the Rieske protein and that Rieske protein plays important roles in the conformation and functionality of mitochondrial supercomplex III/IV in the electron transport chain.
      Title: Iba57p participates in maturation of a [2Fe-2S]-cluster Rieske protein and in formation of supercomplexes III/IV of Saccharomyces cerevisiae electron transport chain.
    2. Yeast COG0354 represents an ancient, folate-dependent protein family involved in the metabolism of Fe/S cluster containing enzymes
      Title: A role for tetrahydrofolates in the metabolism of iron-sulfur clusters in all domains of life.
    3. Mitochondrial Iba57 is required for Fe/S cluster formation on aconitase and activation of radical SAM enzymes.
      Title: Mitochondrial Iba57p is required for Fe/S cluster formation on aconitase and activation of radical SAM enzymes.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in iron-sulfur cluster assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein maturation by [2Fe-2S] cluster transfer IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein maturation by [4Fe-4S] cluster transfer IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Iba57p
    NP_012656.1
    • Protein involved in incorporating iron-sulfur clusters into proteins; mitochondrial matrix protein; involved in the incorporation of iron-sulfur clusters into mitochondrial aconitase-type proteins; activates the radical-SAM family members Bio2p and Lip5p; interacts with Ccr4p in the two-hybrid system

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      649776..651269
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181780.1 → NP_012656.1  TPA: Iba57p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012656.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWU1, P47158
      UniProtKB/TrEMBL
      A6ZQ78, B3LQK6, C7GM90, C8ZBS0, G2WHC5, N1P1R9
      Conserved Domains (1) summary
      COG0354
      Location:147 → 492
      YgfZ; Folate-binding Fe-S cluster repair protein YgfZ, possible role in tRNA modification [Posttranslational modification, protein turnover, chaperones]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P47158.1

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