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    ECI1 dodecenoyl-CoA isomerase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850990, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ECI1
    Official Full Name
    dodecenoyl-CoA isomerase
    Primary source
    SGD:S000004274
    Locus tag
    YLR284C
    See related
    AllianceGenome:SGD:S000004274; FungiDB:YLR284C; VEuPathDB:YLR284C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables delta(3)-delta(2)-enoyl-CoA isomerase activity. Involved in fatty acid beta-oxidation. Located in peroxisome. Orthologous to several human genes including CDYL2 (chromodomain Y like 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ECI1 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (706198..707040, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Rso55p Neighboring gene Put7p Neighboring gene S-adenosylmethionine-dependent methyltransferase Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural studies on delta(3)-delta(2)-enoyl-CoA isomerase: the variable mode of assembly of the trimeric disks of the crotonase superfamily. Mursula AM, et al. FEBS Lett, 2004 Jan 16. PMID 14741345
    2. The crystal structure of delta(3)-delta(2)-enoyl-CoA isomerase. Mursula AM, et al. J Mol Biol, 2001 Jun 15. PMID 11399063
    3. Peroxisomal Delta3-cis-Delta2-trans-enoyl-CoA isomerase encoded by ECI1 is required for growth of the yeast Saccharomyces cerevisiae on unsaturated fatty acids. Gurvitz A, et al. J Biol Chem, 1998 Nov 20. PMID 9813046
    4. Molecular characterization of Saccharomyces cerevisiae Delta3, Delta2-enoyl-CoA isomerase. Geisbrecht BV, et al. J Biol Chem, 1998 Dec 11. PMID 9837886
    5. Crystallization and X-ray diffraction analysis of peroxisomal Delta3-Delta2-enoyl-CoA isomerase from Saccharomyces cerevisiae. Mursula AM, et al. Acta Crystallogr D Biol Crystallogr, 2000 Aug. PMID 10944342

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Here the mode of binding of acyl-CoA substrate analogues to peroxisomal Dodecenoyl-CoA Isomerase Saccharomyces cerevisiae is described.
      Title: Structures of yeast peroxisomal Δ(3),Δ(2)-enoyl-CoA isomerase complexed with acyl-CoA substrate analogues: the importance of hydrogen-bond networks for the reactivity of the catalytic base and the oxyanion hole.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables delta(3)-delta(2)-enoyl-CoA isomerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables delta(3)-delta(2)-enoyl-CoA isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables delta(3)-delta(2)-enoyl-CoA isomerase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty acid beta-oxidation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid beta-oxidation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in fatty acid beta-oxidation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in peroxisomal matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    dodecenoyl-CoA isomerase
    NP_013386.1
    • Peroxisomal delta3,delta2-enoyl-CoA isomerase; hexameric protein that converts 3-hexenoyl-CoA to trans-2-hexenoyl-CoA, essential for the beta-oxidation of unsaturated fatty acids, oleate-induced; ECI1 has a paralog, DCI1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      706198..707040 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182171.1 → NP_013386.1  TPA: dodecenoyl-CoA isomerase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013386.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VYS8, Q05871
      UniProtKB/TrEMBL
      A7A1G5, B3RHG3, B5VNJ0, C7GVS9, C8ZDP7, G2WJA6, N1NZJ5
      Conserved Domains (1) summary
      COG1024
      Location:6 → 243
      CaiD; Enoyl-CoA hydratase/carnithine racemase [Lipid transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q05871.1

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