Flrt3 fibronectin leucine rich transmembrane protein 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Flrt3provided by MGI
Official Full Name: fibronectin leucine rich transmembrane protein 3provided by MGI
Primary source: MGI:MGI:1918686
See related: Ensembl:ENSMUSG00000051379 AllianceGenome:MGI:1918686
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mKIAA1469; 5530600M07Rik; C430047I10Rik
Summary: Enables chemorepellent activity and fibroblast growth factor receptor binding activity. Involved in several processes, including fibroblast growth factor receptor signaling pathway; proepicardium cell migration involved in pericardium morphogenesis; and synapse organization. Acts upstream of or within positive regulation of synapse assembly. Located in several cellular components, including axonal growth cone; cell-cell junction; and extracellular space. Is active in glutamatergic synapse and postsynaptic membrane. Colocalizes with focal adhesion. Is expressed in several structures, including alimentary system; brain; embryo ectoderm; embryo mesenchyme; and eye. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 21 with or without anosmia. Orthologous to human FLRT3 (fibronectin leucine rich transmembrane protein 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in CNS E11.5 (RPKM 7.2), bladder adult (RPKM 5.0) and 16 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 F3; 2 69.2 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (140500118..140513396, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (140658198..140671476, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FLRT2 and FLRT3 Cooperate in Maintaining the Tangential Migratory Streams of Cortical Interneurons during Development.
Title: FLRT2 and FLRT3 Cooperate in Maintaining the Tangential Migratory Streams of Cortical Interneurons during Development.
Mice with deletions of FLRT1 and FLRT3 adhesion molecules develop macroscopic sulci with preserved layered organization and radial glial morphology. Cortex folding in these mutants does not require progenitor cell amplification but is dependent on changes in neuron migration.
Title: Regulation of Cerebral Cortex Folding by Controlling Neuronal Migration via FLRT Adhesion Molecules.
The crystal structure of the OLF/FLRT3 complex shows that LPHN3-OLF in the closed state binds with high affinity to the concave face of FLRT3-LRR with a combination of hydrophobic and charged residues.
Title: Structural and Mechanistic Insights into the Latrophilin3-FLRT3 Complex that Mediates Glutamatergic Synapse Development.
FLRT3 is a modulator of Netrin-1 response in axons.FLRT3 is a Robo1 coreceptor.FLRT3 is a Robo1-interacting protein that determines Netrin-1 attraction in developing axons.
Title: FLRT3 is a Robo1-interacting protein that determines Netrin-1 attraction in developing axons.
Flrt3 was highly expressed initially in the midbrain.
Title: Flrt2 and Flrt3 have overlapping and non-overlapping expression during craniofacial development.
Data demonstrate that FLRT3 plays a key role in controlling cell adhesion and tissue morphogenesis in the developing mouse embryo.
Title: Ventral closure, headfold fusion and definitive endoderm migration defects in mouse embryos lacking the fibronectin leucine-rich transmembrane protein FLRT3.
FLRT3 has an expression pattern during somite development
Title: Regulated expression of FLRT genes implies a functional role in the regulation of FGF signalling during mouse development.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BB462515 (e-PCR)
- UniSTS:207410

Flrt3 (e-PCR), detects polymorphism
- UniSTS:497483

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables chemorepellent activity	IDA Inferred from Direct Assay more info	PubMed
enables fibroblast growth factor receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within axon guidance	ISO Inferred from Sequence Orthology more info	PubMed
involved_in cell-cell adhesion via plasma-membrane adhesion molecules	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell-cell adhesion via plasma-membrane adhesion molecules	ISO Inferred from Sequence Orthology more info
involved_in embryonic morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fibroblast growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in head development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heart development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in neuron projection development	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuron projection extension	ISO Inferred from Sequence Orthology more info
involved_in neuron projection extension	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of synapse assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in proepicardium cell migration involved in pericardium morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to axon injury	ISO Inferred from Sequence Orthology more info
involved_in response to axon injury	ISS Inferred from Sequence or Structural Similarity more info
involved_in synapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synapse organization	ISO Inferred from Sequence Orthology more info
involved_in synaptic membrane adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in synaptic membrane adhesion	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in axon terminus	ISO Inferred from Sequence Orthology more info
located_in axon terminus	ISS Inferred from Sequence or Structural Similarity more info
located_in axonal growth cone	IDA Inferred from Direct Assay more info	PubMed
located_in cell junction	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with focal adhesion	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IEP Inferred from Expression Pattern more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in growth cone membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info
located_in postsynaptic density	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic membrane	IEP Inferred from Expression Pattern more info	PubMed
is_active_in postsynaptic membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in synaptic membrane	ISO Inferred from Sequence Orthology more info
located_in synaptic membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: leucine-rich repeat transmembrane protein FLRT3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001172160.1 → NP_001165631.1 leucine-rich repeat transmembrane protein FLRT3 precursor

See identical proteins and their annotated locations for NP_001165631.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AK031464, AK129369, AL928700, AV157204, BG091701

Consensus CDS

CCDS16806.1

UniProtKB/Swiss-Prot

Q6ZPQ1, Q8BGT1

Related

ENSMUSP00000053399.4, ENSMUST00000056760.4

Conserved Domains (8) summary

smart00013
Location:31 → 61

LRRNT; Leucine rich repeat N-terminal domain

smart00082
Location:305 → 356

LRRCT; Leucine rich repeat C-terminal domain

cd00116
Location:107 → 327

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00031
Location:61 → 84

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:85 → 104

LRR_RI; leucine-rich repeat [structural motif]

pfam00041
Location:413 → 478

fn3; Fibronectin type III domain

pfam12799
Location:61 → 100

LRR_4; Leucine Rich repeats (2 copies)

pfam13855
Location:247 → 306

LRR_8; Leucine rich repeat
NM_178382.4 → NP_848469.1 leucine-rich repeat transmembrane protein FLRT3 precursor

See identical proteins and their annotated locations for NP_848469.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AK031464, AL928700, AV157204, BG091701

Consensus CDS

CCDS16806.1

UniProtKB/Swiss-Prot

Q6ZPQ1, Q8BGT1

Related

ENSMUSP00000105684.3, ENSMUST00000110057.3

Conserved Domains (8) summary

smart00013
Location:31 → 61

LRRNT; Leucine rich repeat N-terminal domain

smart00082
Location:305 → 356

LRRCT; Leucine rich repeat C-terminal domain

cd00116
Location:107 → 327

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00031
Location:61 → 84

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:85 → 104

LRR_RI; leucine-rich repeat [structural motif]

pfam00041
Location:413 → 478

fn3; Fibronectin type III domain

pfam12799
Location:61 → 100

LRR_4; Leucine Rich repeats (2 copies)

pfam13855
Location:247 → 306

LRR_8; Leucine rich repeat