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    Rme-8 Receptor mediated endocytosis 8 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35939, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Rme-8provided by FlyBase
    Official Full Name
    Receptor mediated endocytosis 8provided by FlyBase
    Primary source
    FLYBASE:FBgn0015477
    Locus tag
    Dmel_CG8014
    See related
    AllianceGenome:FB:FBgn0015477
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8014; Dmel\CG8014; E(shi)2-1; l(2)45Ba; rme-8
    Summary
    Involved in positive regulation of border follicle cell migration and receptor-mediated endocytosis. Predicted to be active in endosome membrane. Is expressed in several structures, including Malpighian tubule primordium; adult head; embryonic Malpighian tubule; embryonic/larval garland cell; and spermatozoon. Human ortholog(s) of this gene implicated in Parkinson's disease. Orthologous to human DNAJC13 (DnaJ heat shock protein family (Hsp40) member C13). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Rme-8 in Genome Data Viewer
    Location:
    45B1-45B2; 2-60 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9167763..9177261, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5055268..5064766, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Rad51 recombinase D Neighboring gene uncharacterized protein Neighboring gene Rab32 Neighboring gene long non-coding RNA:CR44284 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A genetic screen in Drosophila uncovers a role for senseless-2 in surface glia in the peripheral nervous system to regulate CNS morphology. Lacin H, et al. G3 (Bethesda), 2024 Sep 4. PMID 38996053, Free PMC Article
    2. Rme-8 depletion perturbs Notch recycling and predisposes to pathogenic signaling. Gomez-Lamarca MJ, et al. J Cell Biol, 2015 Jul 20. PMID 26169355, Free PMC Article
    3. The J-domain protein Rme-8 interacts with Hsc70 to control clathrin-dependent endocytosis in Drosophila. Chang HC, et al. J Cell Biol, 2004 Mar 29. PMID 15051737, Free PMC Article
    4. [Cytogenetic analysis of the chromosome region containing the Drosophila radiosensitivity gene. II. The vitally important loci of the 44F-45C region of chromosome 2]. Konev AIu, et al. Genetika, 1994 Feb. PMID 8045382
    5. The small G protein Arl8 contributes to lysosomal function and long-range axonal transport in Drosophila. Rosa-Ferreira C, et al. Biol Open, 2018 Sep 5. PMID 30115618, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Rme-8 is necessary for normal Notch recycling.
      Title: Rme-8 depletion perturbs Notch recycling and predisposes to pathogenic signaling.
    2. Endosomal organization and the distribution of clathrin were greatly disrupted in Rme-8 cells, suggesting that Rme-8 participates in a clathrin-dependent process.
      Title: The J-domain protein Rme-8 interacts with Hsc70 to control clathrin-dependent endocytosis in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in endosome organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of border follicle cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in receptor-mediated endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in receptor-mediated endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of early endosome to late endosome transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    receptor mediated endocytosis 8
    Names
    CG8014-PA
    CG8014-PB
    Rme-8-PA
    Rme-8-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      9167763..9177261 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299307.1 → NP_001286236.1  receptor mediated endocytosis 8, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286236.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LFW6
      Conserved Domains (3) summary
      pfam00226
      Location:1303 → 1355
      DnaJ; DnaJ domain
      pfam14237
      Location:971 → 1019
      DUF4339; Domain of unknown function (DUF4339)
      sd00044
      Location:2173 → 2199
      HEAT; HEAT repeat [structural motif]

    2. NM_136623.2 → NP_610467.1  receptor mediated endocytosis 8, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610467.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z7S0
      Related
      FBpp0087699
      Conserved Domains (3) summary
      pfam00226
      Location:1304 → 1356
      DnaJ; DnaJ domain
      pfam14237
      Location:972 → 1020
      DUF4339; Domain of unknown function (DUF4339)
      sd00044
      Location:2174 → 2200
      HEAT; HEAT repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LFW6 A0A0B4LFW6
    A1Z7S0 A1Z7S0

    Gene LinkOut

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