opa odd paired [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: opaprovided by FlyBase
Official Full Name: odd pairedprovided by FlyBase
Primary source: FLYBASE:FBgn0003002
Locus tag: Dmel_CG1133
See related: AllianceGenome:FB:FBgn0003002
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG1133; Dmel\CG1133; Opa
Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including eye-antennal disc morphogenesis; germ cell migration; and midgut development. Located in nucleus. Is expressed in several structures, including dorsal ectoderm; dorsal ectoderm anlage; embryonic/larval midgut; germ layer; and parasegment. Human ortholog(s) of this gene implicated in Dandy-Walker syndrome; X-linked VACTERL association; craniosynostosis; holoprosencephaly (multiple); and visceral heterotaxy (multiple). Orthologous to several human genes including ZIC5 (Zic family member 5). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (4852813..4869979)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (678535..695701)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Opa protein is a novel regulator of embryonic Alk expression.
Title: The Zic family homologue Odd-paired regulates Alk expression in Drosophila.
The Zic family member, odd-paired, regulates the Drosophila BMP, decapentaplegic, during adult head development.
Title: The Zic family member, odd-paired, regulates the Drosophila BMP, decapentaplegic, during adult head development.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in central nervous system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in eye-antennal disc morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in midgut development	IEP Inferred from Expression Pattern more info	PubMed
involved_in midgut development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

Names: CG1133-PA; CG1133-PB; GLI-Kr zinc finger pair-rule protein; Odd paired; Odd-paired; opa-PA; opa-PB

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The following sections contain reference sequences that belong to a specific genome build. Explain