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    nagB glucosamine-6-phosphate deaminase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945290, updated on 17-Dec-2024

    Summary

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    Official Symbol
    nagB
    Official Full Name
    glucosamine-6-phosphate deaminase
    Primary source
    ECOCYC:EG10633
    Locus tag
    b0678
    See related
    ASAP:ABE-0002304
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0666; glmD
    Summary
    Glucosamine-6-phosphate deaminase catalyzes the second cytoplasmic reaction in the metabolism of N-acetyl-D-glucosamine. [More information is available at EcoCyc: EG10633].
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    Genomic context

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    Sequence:
    NC_000913.3 (702811..703611, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional dual regulator NagC Neighboring gene N-acetylglucosamine-6-phosphate deacetylase Neighboring gene N-acetylglucosamine-specific PTS enzyme IIABC component Neighboring gene glutamine--tRNA ligase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. On the role of the conformational flexibility of the active-site lid on the allosteric kinetics of glucosamine-6-phosphate deaminase. Bustos-Jaimes I, et al. J Mol Biol, 2002 May 24. PMID 12051945
    2. Glucosamine-6-phosphate deaminase from Escherichia coli has a trimer of dimers structure with three intersubunit disulphides. Altamirano MM, et al. Biochem J, 1993 Nov 1. PMID 8240271, Free PMC Article
    3. Differential scanning calorimetry of the irreversible denaturation of Escherichia coli glucosamine-6-phosphate deaminase. Hernández-Arana A, et al. Biochemistry, 1993 Apr 13. PMID 8466906
    4. Spectrochemical evidence for the presence of a tyrosine residue in the allosteric site of glucosamine-6-phosphate deaminase from Escherichia coli. Altamirano MM, et al. Eur J Biochem, 1994 Mar 1. PMID 8125098
    5. Asymmetric allosteric activation of Escherichia coli glucosamine-6-phosphate deaminase produced by replacements of Tyr 121. Altamirano MM, et al. Biochemistry, 1995 May 9. PMID 7742311

    See all (61) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. We provide evidence here that NanE, GlcNAc-6P epimerase, and the uridylylated PII protein allosterically activate NagB by direct protein-protein interactions.
      Title: The Nitrogen Regulatory PII Protein (GlnB) and N-Acetylglucosamine 6-Phosphate Epimerase (NanE) Allosterically Activate Glucosamine 6-Phosphate Deaminase (NagB) in Escherichia coli.
    2. Data indicate the existence of tertiary mixed forms at glucosamine-6-phosphate deaminase (EcGNPDA) T conformers.
      Title: The tertiary origin of the allosteric activation of E. coli glucosamine-6-phosphate deaminase studied by sol-gel nanoencapsulation of its T conformer.
    3. strains carrying a wild-type deaminase (nagB) gene, increasing the level of the NagB protein or the rate of GlcN uptake increased the growth rate, which showed that both enzyme induction and sugar transport were limiting.
      Title: Why does Escherichia coli grow more slowly on glucosamine than on N-acetylglucosamine? Effects of enzyme levels and allosteric activation of GlcN6P deaminase (NagB) on growth rates.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables glucosamine-6-phosphate deaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glucosamine-6-phosphate deaminase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glucosamine-6-phosphate deaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in N-acetylglucosamine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within N-acetylglucosamine catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in N-acetylglucosamine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in N-acetylneuraminate catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in N-acetylneuraminate catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within N-acetylneuraminate catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in UDP-N-acetylglucosamine biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glucosamine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    glucosamine-6-phosphate deaminase
    NP_415204.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      702811..703611 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415204.1 glucosamine-6-phosphate deaminase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415204.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2W6PD60, A0A2X1NWT2, A0AAN3KVT3
      Conserved Domains (1) summary
      TIGR00502
      Location:1 → 259
      nagB; glucosamine-6-phosphate isomerase
    Nucleotide Protein
    Heading Accession and Version

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