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    Csp Cysteine string protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40459, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cspprovided by FlyBase
    Official Full Name
    Cysteine string proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0004179
    Locus tag
    Dmel_CG6395
    See related
    AllianceGenome:FB:FBgn0004179
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    ab49; anon-WO02059370.50; CG6395; csp; CSP; csp29; csp32; CSP32; Cys; D-CSP; D.M.CSP; Dcsp; DCSP-1; dCSP-2; dCSPalpha; Dmel\CG6395; DNAJC5; DSP/DNAJC5; l(3)03988; MAB ab49
    Summary
    Involved in exocytosis; neuron cellular homeostasis; and regulation of neuromuscular synaptic transmission. Located in synaptic vesicle; type Ib terminal bouton; and type Is terminal bouton. Is expressed in several structures, including anterior-posterior subdivision of organism; neuromuscular junction; photoreceptor neurons; somatic muscle cell; and synaptic neuropil domain. Used to study neuronal ceroid lipofuscinosis 4. Human ortholog(s) of this gene implicated in neuronal ceroid lipofuscinosis 4. Orthologous to human DNAJC5 (DnaJ heat shock protein family (Hsp40) member C5) and DNAJC5B (DnaJ heat shock protein family (Hsp40) member C5 beta). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Csp in Genome Data Viewer
    Location:
    79D3-79D3; 3-47 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (22267382..22273745)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (22260482..22266845)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene RIC1 homolog Neighboring gene Dead-box-1 Neighboring gene uncharacterized protein Neighboring gene stable intronic sequence RNA 3 Neighboring gene antisense RNA:CR45960 Neighboring gene Serine-arginine protein kinase at 79D Neighboring gene HEM-protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A cysteine-string protein is expressed in retina and brain of Drosophila. Zinsmaier KE, et al. J Neurogenet, 1990 Nov. PMID 2129171
    2. Morphological and functional effects of altered cysteine string protein at the Drosophila larval neuromuscular junction. Dawson-Scully K, et al. Synapse, 2007 Jan. PMID 17068777
    3. The DnaJ-like cysteine string protein and exocytotic neurotransmitter release. Buchner E, et al. Trends Neurosci, 1997 May. PMID 9141199
    4. Serial Recombineering Cloning to Build Selectable and Tagged Genomic P[acman] BAC Clones for Selection Transgenesis and Functional Gene Analysis using Drosophila melanogaster. Venken KJT, et al. Curr Protoc, 2023 Feb. PMID 36757632, Free PMC Article
    5. Multiplexed Transgenic Selection and Counterselection Strategies to Expedite Genetic Manipulation Workflows Using Drosophila melanogaster. Venken KJT, et al. Curr Protoc, 2023 Feb. PMID 36757287, Free PMC Article

    See all (317) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This review summarizes studies that elucidate the neuroprotective role of Drosophila CSP, which is critical for maintaining neurotransmitter release and preventing neurodegeneration.
      Title: Cysteine-string protein's neuroprotective role.
    2. Our data indicate that HIP14 controls neurotransmitter release by regulating the trafficking of CSP to synapses.
      Title: Huntingtin-interacting protein 14, a palmitoyl transferase required for exocytosis and targeting of CSP to synaptic vesicles.
    3. study found dHIP14 to be an essential maternal effect gene required for photoreceptor synaptic transmission and for proper in vivo expression of the palmitoylated presynaptic proteins SNAP-25 and cysteine string protein
      Title: Drosophila huntingtin-interacting protein 14 is a presynaptic protein required for photoreceptor synaptic transmission and expression of the palmitoylated proteins synaptosome-associated protein 25 and cysteine string protein.
    4. these data suggest that CSP promotes synaptic growth and evoked neurotransmitter release by mechanistically independent signaling pathways
      Title: Morphological and functional effects of altered cysteine string protein at the Drosophila larval neuromuscular junction.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuron cellular homeostasis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein folding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of neuromuscular synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of neuromuscular synaptic transmission IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in synaptic vesicle exocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in terminal bouton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in type Ib terminal bouton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in type Is terminal bouton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in type Is terminal bouton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cysteine string protein
    Names
    CG6395-PA
    CG6395-PB
    CG6395-PC
    CG6395-PD
    CG6395-PE
    CG6395-PF
    Csp-PA
    Csp-PB
    Csp-PC
    Csp-PD
    Csp-PE
    Csp-PF
    cystein string protein
    cysteine string protein 3
    cysteine-string protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      22267382..22273745
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300215.1 → NP_001287144.1  cysteine string protein, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287144.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O61664, O61665, Q03751, Q95TD7, Q9VNV1
      UniProtKB/TrEMBL
      D0IQJ8
      Conserved Domains (2) summary
      COG0484
      Location:17 → 86
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      pfam00226
      Location:17 → 79
      DnaJ; DnaJ domain

    2. NM_001275278.1 → NP_001262207.1  cysteine string protein, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262207.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O61664, O61665, Q03751, Q95TD7, Q9VNV1
      UniProtKB/TrEMBL
      M9PG83
      Conserved Domains (2) summary
      COG0484
      Location:17 → 86
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      pfam00226
      Location:17 → 79
      DnaJ; DnaJ domain

    3. NM_079489.3 → NP_524213.1  cysteine string protein, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524213.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O61664, O61665, Q03751, Q95TD7, Q9VNV1
      Related
      FBpp0078145
      Conserved Domains (2) summary
      COG0484
      Location:17 → 86
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      pfam00226
      Location:17 → 79
      DnaJ; DnaJ domain

    4. NM_168950.4 → NP_730714.2  cysteine string protein, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730714.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O61664, O61665, Q03751, Q95TD7, Q9VNV1
      UniProtKB/TrEMBL
      C5WLN6
      Related
      FBpp0078147
      Conserved Domains (2) summary
      COG0484
      Location:17 → 86
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      pfam00226
      Location:17 → 79
      DnaJ; DnaJ domain

    5. NM_168949.2 → NP_730713.1  cysteine string protein, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730713.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O61664, O61665, Q03751, Q95TD7, Q9VNV1
      UniProtKB/TrEMBL
      D0IQJ8
      Related
      FBpp0078146
      Conserved Domains (2) summary
      COG0484
      Location:17 → 86
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      pfam00226
      Location:17 → 79
      DnaJ; DnaJ domain

    6. NM_001275277.1 → NP_001262206.1  cysteine string protein, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262206.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O61664, O61665, Q03751, Q95TD7, Q9VNV1
      UniProtKB/TrEMBL
      M9PG83
      Conserved Domains (2) summary
      COG0484
      Location:17 → 86
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      pfam00226
      Location:17 → 79
      DnaJ; DnaJ domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D0IQJ8 D0IQJ8
    M9PG83 M9PG83
    Q03751.1 Q03751

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