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    Il2rg interleukin 2 receptor subunit gamma [ Rattus norvegicus (Norway rat) ]

    Gene ID: 140924, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Il2rgprovided by RGD
    Official Full Name
    interleukin 2 receptor subunit gammaprovided by RGD
    Primary source
    RGD:621466
    See related
    EnsemblRapid:ENSRNOG00000003954 AllianceGenome:RGD:621466
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cd132; Ab2-183
    Summary
    Predicted to enable coreceptor activity; interleukin-15 receptor activity; and interleukin-2 binding activity. Predicted to be involved in cellular homeostasis; cytokine-mediated signaling pathway; and positive regulation of phagocytosis. Predicted to act upstream of or within positive regulation of gene expression and positive regulation of lymphocyte differentiation. Predicted to be located in endoplasmic reticulum; external side of plasma membrane; and nucleoplasm. Predicted to be active in plasma membrane. Used to study X-linked severe combined immunodeficiency and combined T cell and B cell immunodeficiency. Human ortholog(s) of this gene implicated in X-linked severe combined immunodeficiency; combined T cell and B cell immunodeficiency; and severe combined immunodeficiency. Orthologous to human IL2RG (interleukin 2 receptor subunit gamma). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 646.5), Spleen (RPKM 370.5) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Il2rg in Genome Data Viewer
    Location:
    Xq22
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (70435340..70439052, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (66395330..66399026, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (71165378..71169078, complement)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene forkhead box O4 Neighboring gene similar to human chromosome X open reading frame 65 Neighboring gene mediator complex subunit 12 Neighboring gene neuroligin 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Generation of knockout rats with X-linked severe combined immunodeficiency (X-SCID) using zinc-finger nucleases. Mashimo T, et al. PLoS One, 2010 Jan 25. PMID 20111598, Free PMC Article
    2. Generation of Immunodeficient Rats With Rag1 and Il2rg Gene Deletions and Human Tissue Grafting Models. Ménoret S, et al. Transplantation, 2018 Aug. PMID 29688994
    3. Screening for mutations causing X-linked severe combined immunodeficiency in the IL-2R gamma chain gene by single-strand conformation polymorphism analysis. Clark PA, et al. Hum Genet, 1995 Oct. PMID 7557965
    4. Structural basis for binding multiple ligands by the common cytokine receptor gamma-chain. Olosz F, et al. J Biol Chem, 2002 Apr 5. PMID 11815609
    5. Role of Bcl-2 in alpha beta T cell development in mice deficient in the common cytokine receptor gamma-chain: the requirement for Bcl-2 differs depending on the TCR/MHC affinity. Nakajima H, et al. J Immunol, 1999 Jan 15. PMID 9916699

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structural basis for binding multiple ligands by the common cytokine receptor gamma-chain
      Title: Structural basis for binding multiple ligands by the common cytokine receptor gamma-chain.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables coreceptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables interleukin-15 receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables interleukin-2 binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of B cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of T cell differentiation in thymus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in interleukin-15-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in interleukin-2-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in interleukin-7-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in interleukin-9-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of lymphocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of mature B cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of B cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of T cell differentiation in thymus ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of phagocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cytokine receptor common subunit gamma
    Names
    interleukin 2 receptor, gamma (severe combined immunodeficiency)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_080889.1 → NP_543165.1  cytokine receptor common subunit gamma precursor

      See identical proteins and their annotated locations for NP_543165.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079343
      UniProtKB/TrEMBL
      A6IQA7, F7ER36, Q68FU6
      Related
      ENSRNOP00000005343.5, ENSRNOT00000005343.9
      Conserved Domains (2) summary
      cd00063
      Location:154 → 246
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl21522
      Location:59 → 116
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      70435340..70439052 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063279764.1 → XP_063135834.1  cytokine receptor common subunit gamma isoform X1

      UniProtKB/TrEMBL
      A6IQA8, D3JTH6

    2. XM_017601899.3 → XP_017457388.1  cytokine receptor common subunit gamma isoform X2

      UniProtKB/TrEMBL
      D3JTH6
    Nucleotide Protein Strain
    Heading Accession and Version

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