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    Tsp42Eq Tetraspanin 42Eq [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35628, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Tsp42Eqprovided by FlyBase
    Official Full Name
    Tetraspanin 42Eqprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033138
    Locus tag
    Dmel_CG12832
    See related
    AllianceGenome:FB:FBgn0033138
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12832; Dm.Tsp42Eq; Dmel\CG12832
    Summary
    Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in adult head. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Tsp42Eq in Genome Data Viewer
    Location:
    42E7-42E7; 2-55 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7062108..7063569, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (2949613..2951074, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Tetraspanin 42Ep Neighboring gene Tetraspanin 42Eo Neighboring gene Polypeptide N-Acetylgalactosaminyltransferase 3 Neighboring gene Tetraspanin 42Er Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Glial TGFβ activity promotes neuron survival in peripheral nerves. Lassetter AP, et al. J Cell Biol, 2023 Jan 2. PMID 36399182, Free PMC Article
    2. A mucin-type O-glycosyltransferase modulates cell adhesion during Drosophila development. Zhang L, et al. J Biol Chem, 2008 Dec 5. PMID 18835818, Free PMC Article
    3. A Drosophila DEG/ENaC channel subunit is required for male response to female pheromones. Lin H, et al. Proc Natl Acad Sci U S A, 2005 Sep 6. PMID 16129837, Free PMC Article
    4. Involvement of CD9 and PDGFR in migration is evolutionarily conserved from Drosophila glia to human glioma. Jeibmann A, et al. J Neurooncol, 2015 Sep. PMID 26224160
    5. Genomewide analysis of the Drosophila tetraspanins reveals a subset with similar function in the formation of the embryonic synapse. Fradkin LG, et al. Proc Natl Acad Sci U S A, 2002 Oct 15. PMID 12370414, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tetraspanin 42Eq
    Names
    CG12832-PA
    Tsp42Eq-PA
    tetraspanin 42E

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      7062108..7063569 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078919.3 → NP_523643.2  tetraspanin 42Eq [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523643.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z6U8
      Related
      FBpp0088129
      Conserved Domains (2) summary
      cd03127
      Location:95 → 173
      tetraspanin_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the ...
      pfam00335
      Location:8 → 209
      Tetraspannin; Tetraspanin family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z6U8 A1Z6U8
    Q8SZ98 Q8SZ98

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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