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    HUWE1 HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1 [ Homo sapiens (human) ]

    Gene ID: 10075, updated on 27-Dec-2024

    Summary

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    Official Symbol
    HUWE1provided by HGNC
    Official Full Name
    HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1provided by HGNC
    Primary source
    HGNC:HGNC:30892
    See related
    Ensembl:ENSG00000086758 MIM:300697; AllianceGenome:HGNC:30892
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MULE; Ib772; LASU1; MRXST; UREB1; HECTH9; URE-B1; ARF-BP1; HSPC272
    Summary
    This gene encodes a protein containing a C-terminal HECT (E6AP type E3 ubiquitin protein ligase) domain that functions as an E3 ubiquitin ligase. The encoded protein is required for the ubiquitination and subsequent degradation of the anti-apoptotic protein Mcl1 (myeloid cell leukemia sequence 1 (BCL2-related)). This protein also ubiquitinates the p53 tumor suppressor, core histones, and DNA polymerase beta. Mutations in this gene are associated with Turner type X-linked syndromic cognitive disability. [provided by RefSeq, Aug 2013]
    Expression
    Ubiquitous expression in ovary (RPKM 14.5), testis (RPKM 13.8) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See HUWE1 in Genome Data Viewer
    Location:
    Xp11.22
    Exon count:
    87
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (53532096..53686719, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (52818443..52973077, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (53559057..53713664, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene vault RNA 3-1, pseudogene Neighboring gene Sharpr-MPRA regulatory region 13191 Neighboring gene TIPIN pseudogene 1 Neighboring gene MED14-independent group 3 enhancer GRCh37_chrX:53588722-53589921 Neighboring gene microRNA let-7f-2 Neighboring gene microRNA 98 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chrX:53619238-53620437 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29663 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20859 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:53713671-53713845 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29664 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:53739227-53739726 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29665 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29666 Neighboring gene MED14-independent group 3 enhancer GRCh37_chrX:53742749-53743948 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29667 Neighboring gene MRPL32 pseudogene 2 Neighboring gene MRPS18C pseudogene 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Exome sequencing reveals a novel splice site variant in HUWE1 gene in patients with suspected Say-Meyer syndrome. Muthusamy B, et al. Eur J Med Genet, 2020 Jan. PMID 30797980, Free PMC Article
    2. Shh signaling protects Atoh1 from degradation mediated by the E3 ubiquitin ligase Huwe1 in neural precursors. Forget A, et al. Dev Cell, 2014 Jun 23. PMID 24960692
    3. Novel microduplications at Xp11.22 including HUWE1: clinical and molecular insights into these genomic rearrangements associated with intellectual disability. Santos-Rebouças CB, et al. J Hum Genet, 2015 Apr. PMID 25652354
    4. Copy-number gains of HUWE1 due to replication- and recombination-based rearrangements. Froyen G, et al. Am J Hum Genet, 2012 Aug 10. PMID 22840365, Free PMC Article
    5. The giant E3 ligase HUWE1 is linked to tumorigenesis, spermatogenesis, intellectual disability, and inflammatory diseases. Qi L, et al. Front Cell Infect Microbiol, 2022. PMID 35937685, Free PMC Article

    See all (380) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The E3 ligase HUWE1 increases the sensitivity of CRC to oxaliplatin through TOMM20 degradation.
      Title: The E3 ligase HUWE1 increases the sensitivity of CRC to oxaliplatin through TOMM20 degradation.
    2. The role of KDM4A-mediated histone methylation on temozolomide resistance in glioma cells through the HUWE1/ROCK2 axis.
      Title: The role of KDM4A-mediated histone methylation on temozolomide resistance in glioma cells through the HUWE1/ROCK2 axis.
    3. A novel SNP in HUWE1 promoter confers increased risk of NOA by affecting the RA/RARalpha pathway in Chinese individuals.
      Title: A novel SNP in HUWE1 promoter confers increased risk of NOA by affecting the RA/RARα pathway in Chinese individuals.
    4. A HUWE1 defect causes PARP inhibitor resistance by modulating the BRCA1-11q splice variant.
      Title: A HUWE1 defect causes PARP inhibitor resistance by modulating the BRCA1-∆11q splice variant.
    5. HUWE1 controls tristetraprolin proteasomal degradation by regulating its phosphorylation.
      Title: HUWE1 controls tristetraprolin proteasomal degradation by regulating its phosphorylation.
    6. The E3 ubiquitin ligase HUWE1 acts through the N-Myc-DLL1-NOTCH1 signaling axis to suppress glioblastoma progression.
      Title: The E3 ubiquitin ligase HUWE1 acts through the N-Myc-DLL1-NOTCH1 signaling axis to suppress glioblastoma progression.
    7. TRIM37 promotes the aggressiveness of ovarian cancer cells and increases c-Myc expression by binding to HUWE1.
      Title: TRIM37 promotes the aggressiveness of ovarian cancer cells and increases c-Myc expression by binding to HUWE1.
    8. The giant E3 ligase HUWE1 is linked to tumorigenesis, spermatogenesis, intellectual disability, and inflammatory diseases.
      Title: The giant E3 ligase HUWE1 is linked to tumorigenesis, spermatogenesis, intellectual disability, and inflammatory diseases.
    9. E3 ligase HUWE1 promotes PDGF D-mediated osteoblastic differentiation of mesenchymal stem cells by effecting polyubiquitination of beta-PDGFR.
      Title: E3 ligase HUWE1 promotes PDGF D-mediated osteoblastic differentiation of mesenchymal stem cells by effecting polyubiquitination of β-PDGFR.
    10. Host E3 ligase HUWE1 attenuates the proapoptotic activity of the MERS-CoV accessory protein ORF3 by promoting its ubiquitin-dependent degradation.
      Title: Host E3 ligase HUWE1 attenuates the proapoptotic activity of the MERS-CoV accessory protein ORF3 by promoting its ubiquitin-dependent degradation.
    Submit: New GeneRIF Correction See all GeneRIFs (90)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Intellectual disability, X-linked syndromic, Turner type
    MedGen: C2678046 OMIM: 309590 GeneReviews: Not available
    		Compare labs

    Copy number response

    Description
    Copy number response
    Haploinsufficency

    No evidence available (Last evaluated 2018-09-26)

    ClinGen Genome Curation Page
    Triplosensitivity

    No evidence available (Last evaluated 2018-09-26)

    ClinGen Genome Curation Page

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase (HUWE1) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Gag-Pol gag-pol Co-immunoprecipitation shows interaction of HIV-1 Gag-Pol with Huwe1 through IN domain (residues 1148-1435) PubMed
    Rev rev HIV-1 Rev interacting protein, HECT, UBA and WWE domain containing 1 (HUWE1), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells PubMed
    Vif vif HIV-1 Vif is identified to have a physical interaction with HECT, UBA and WWE domain containing 1 (HUWE1) in human HEK293 and/or Jurkat cell lines PubMed
    integrase gag-pol Co-immunoprecipitation shows interaction of HIV-1 IN with Huwe1 through the CCD domain of IN PubMed
    retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase (HUWE1) at amino acid residues 3686-3687 by the HIV-1 protease PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0312

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables RNA binding HDA PubMed 
    enables histone ubiquitin ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin-ubiquitin ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Golgi organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in base-excision repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in base-excision repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in circadian regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in membrane fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of mitochondrial fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of peroxisome proliferator activated receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of canonical NF-kappaB signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of protein targeting to mitochondrion HMP PubMed 
    involved_in positive regulation of protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of type 2 mitophagy IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein K48-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein branched polyubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein monoubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein polyubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    		  
    located_in ficolin-1-rich granule lumen TAS
    Traceable Author Statement
    more info
    		  
    located_in membrane HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in secretory granule lumen TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase HUWE1
    Names
    ARF-binding protein 1
    BJ-HCC-24 tumor antigen
    HECT domain protein LASU1
    HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
    HECT-type E3 ubiquitin transferase HUWE1
    Mcl-1 ubiquitin ligase E3
    URE-binding protein 1
    homologous to E6AP carboxyl terminus homologous protein 9
    large structure of UREB1
    upstream regulatory element-binding protein 1
    NP_113584.3
    XP_005262022.1
    XP_011529049.1
    XP_011529053.1
    XP_016884687.1
    XP_016884688.1
    XP_016884691.1
    XP_016884692.1
    XP_047297667.1
    XP_047297668.1
    XP_047297669.1
    XP_047297670.1
    XP_047297671.1
    XP_047297672.1
    XP_047297673.1
    XP_047297674.1
    XP_047297675.1
    XP_047297676.1
    XP_047297677.1
    XP_047297678.1
    XP_047297679.1
    XP_047297680.1
    XP_047297681.1
    XP_047297682.1
    XP_047297683.1
    XP_047297684.1
    XP_047297685.1
    XP_047297686.1
    XP_047297687.1
    XP_047297688.1
    XP_047297689.1
    XP_047297690.1
    XP_047297691.1
    XP_047297692.1
    XP_047297693.1
    XP_047297694.1
    XP_047297695.1
    XP_047297696.1
    XP_047297697.1
    XP_047297698.1
    XP_047297699.1
    XP_047297700.1
    XP_047297701.1
    XP_047297702.1
    XP_047297703.1
    XP_047297704.1
    XP_047297705.1
    XP_047297706.1
    XP_047297707.1
    XP_047297708.1
    XP_054182256.1
    XP_054182257.1
    XP_054182258.1
    XP_054182259.1
    XP_054182260.1
    XP_054182261.1
    XP_054182262.1
    XP_054182263.1
    XP_054182264.1
    XP_054182265.1
    XP_054182266.1
    XP_054182267.1
    XP_054182268.1
    XP_054182269.1
    XP_054182270.1
    XP_054182271.1
    XP_054182272.1
    XP_054182273.1
    XP_054182274.1
    XP_054182275.1
    XP_054182276.1
    XP_054182277.1
    XP_054182278.1
    XP_054182279.1
    XP_054182280.1
    XP_054182281.1
    XP_054182282.1
    XP_054182283.1
    XP_054182284.1
    XP_054182285.1
    XP_054182286.1
    XP_054182287.1
    XP_054182288.1
    XP_054182289.1
    XP_054182290.1
    XP_054182291.1
    XP_054182292.1
    XP_054182293.1
    XP_054182294.1
    XP_054182295.1
    XP_054182296.1
    XP_054182297.1
    XP_054182298.1
    XP_054182299.1
    XP_054182300.1
    XP_054182301.1
    XP_054182302.1
    XP_054182303.1
    XP_054182304.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016261.2 RefSeqGene

      Range
      5015..159638
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_031407.7 → NP_113584.3  E3 ubiquitin-protein ligase HUWE1

      See identical proteins and their annotated locations for NP_113584.3

      Status: REVIEWED

      Source sequence(s)
      AB002310, AC231658, AY772009, BX323845, DQ097177, R60532
      Consensus CDS
      CCDS35301.1
      UniProtKB/Swiss-Prot
      O15029, Q4G2Z2, Q5H961, Q6P4D0, Q7Z6Z7, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9
      UniProtKB/TrEMBL
      A0A994J483
      Related
      ENSP00000262854.6, ENST00000262854.11
      Conserved Domains (7) summary
      smart00119
      Location:4043 → 4371
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:4019 → 4372
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1317 → 1356
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
      pfam02825
      Location:1617 → 1678
      WWE; WWE domain
      pfam06012
      Location:92 → 367
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:430 → 814
      DUF913; Domain of Unknown Function (DUF913)
      pfam14377
      Location:2968 → 3077
      DUF4414; Domain of unknown function (DUF4414)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      53532096..53686719 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047441744.1 → XP_047297700.1  E3 ubiquitin-protein ligase HUWE1 isoform X20

      UniProtKB/TrEMBL
      A0A994J483

    2. XM_047441734.1 → XP_047297690.1  E3 ubiquitin-protein ligase HUWE1 isoform X17

      UniProtKB/TrEMBL
      A0A994J483

    3. XM_047441751.1 → XP_047297707.1  E3 ubiquitin-protein ligase HUWE1 isoform X25

      UniProtKB/TrEMBL
      A0A994J483

    4. XM_047441741.1 → XP_047297697.1  E3 ubiquitin-protein ligase HUWE1 isoform X19

      UniProtKB/TrEMBL
      A0A994J483

    5. XM_011530747.2 → XP_011529049.1  E3 ubiquitin-protein ligase HUWE1 isoform X3

      See identical proteins and their annotated locations for XP_011529049.1

      UniProtKB/TrEMBL
      A0A994J483
      Conserved Domains (7) summary
      cd00078
      Location:4102 → 4455
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1400 → 1439
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
      pfam02825
      Location:1700 → 1761
      WWE; WWE domain
      pfam06012
      Location:92 → 367
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:430 → 897
      DUF913; Domain of Unknown Function (DUF913)
      pfam14377
      Location:3051 → 3160
      DUF4414; Domain of unknown function (DUF4414)
      cl26464
      Location:2818 → 3149
      Atrophin-1; Atrophin-1 family

    6. XM_047441739.1 → XP_047297695.1  E3 ubiquitin-protein ligase HUWE1 isoform X18

      UniProtKB/TrEMBL
      A0A994J483

    7. XM_047441729.1 → XP_047297685.1  E3 ubiquitin-protein ligase HUWE1 isoform X15

      UniProtKB/TrEMBL
      A0A994J483

    8. XM_017029199.2 → XP_016884688.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

      UniProtKB/TrEMBL
      A0A994J483

    9. XM_047441736.1 → XP_047297692.1  E3 ubiquitin-protein ligase HUWE1 isoform X17

      UniProtKB/TrEMBL
      A0A994J483

    10. XM_047441742.1 → XP_047297698.1  E3 ubiquitin-protein ligase HUWE1 isoform X19

      UniProtKB/TrEMBL
      A0A994J483

    11. XM_047441732.1 → XP_047297688.1  E3 ubiquitin-protein ligase HUWE1 isoform X16

      UniProtKB/Swiss-Prot
      O15029, Q4G2Z2, Q5H961, Q6P4D0, Q7Z6Z7, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9
      UniProtKB/TrEMBL
      A0A994J483

    12. XM_047441713.1 → XP_047297669.1  E3 ubiquitin-protein ligase HUWE1 isoform X3

      UniProtKB/TrEMBL
      A0A994J483

    13. XM_047441730.1 → XP_047297686.1  E3 ubiquitin-protein ligase HUWE1 isoform X15

      UniProtKB/TrEMBL
      A0A994J483

    14. XM_017029202.2 → XP_016884691.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

      UniProtKB/TrEMBL
      A0A994J483

    15. XM_047441752.1 → XP_047297708.1  E3 ubiquitin-protein ligase HUWE1 isoform X26

      UniProtKB/TrEMBL
      A0A994J483

    16. XM_047441743.1 → XP_047297699.1  E3 ubiquitin-protein ligase HUWE1 isoform X20

      UniProtKB/TrEMBL
      A0A994J483
      Related
      ENSP00000515693.1, ENST00000704099.1

    17. XM_047441735.1 → XP_047297691.1  E3 ubiquitin-protein ligase HUWE1 isoform X17

      UniProtKB/TrEMBL
      A0A994J483

    18. XM_047441750.1 → XP_047297706.1  E3 ubiquitin-protein ligase HUWE1 isoform X25

      UniProtKB/TrEMBL
      A0A994J483

    19. XM_047441740.1 → XP_047297696.1  E3 ubiquitin-protein ligase HUWE1 isoform X19

      UniProtKB/TrEMBL
      A0A994J483

    20. XM_005261965.5 → XP_005262022.1  E3 ubiquitin-protein ligase HUWE1 isoform X16

      See identical proteins and their annotated locations for XP_005262022.1

      UniProtKB/Swiss-Prot
      O15029, Q4G2Z2, Q5H961, Q6P4D0, Q7Z6Z7, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9
      UniProtKB/TrEMBL
      A0A994J483
      Related
      ENSP00000340648.3, ENST00000342160.7
      Conserved Domains (7) summary
      smart00119
      Location:4043 → 4371
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:4019 → 4372
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1317 → 1356
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
      pfam02825
      Location:1617 → 1678
      WWE; WWE domain
      pfam06012
      Location:92 → 367
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:430 → 814
      DUF913; Domain of Unknown Function (DUF913)
      pfam14377
      Location:2968 → 3077
      DUF4414; Domain of unknown function (DUF4414)

    21. XM_047441714.1 → XP_047297670.1  E3 ubiquitin-protein ligase HUWE1 isoform X3

      UniProtKB/TrEMBL
      A0A994J483

    22. XM_047441738.1 → XP_047297694.1  E3 ubiquitin-protein ligase HUWE1 isoform X18

      UniProtKB/TrEMBL
      A0A994J483

    23. XM_047441728.1 → XP_047297684.1  E3 ubiquitin-protein ligase HUWE1 isoform X15

      UniProtKB/TrEMBL
      A0A994J483

    24. XM_047441747.1 → XP_047297703.1  E3 ubiquitin-protein ligase HUWE1 isoform X22

      UniProtKB/TrEMBL
      A0A994J483

    25. XM_047441727.1 → XP_047297683.1  E3 ubiquitin-protein ligase HUWE1 isoform X14

      UniProtKB/TrEMBL
      A0A994J483

    26. XM_047441724.1 → XP_047297680.1  E3 ubiquitin-protein ligase HUWE1 isoform X11

      UniProtKB/TrEMBL
      A0A994J483

    27. XM_047441722.1 → XP_047297678.1  E3 ubiquitin-protein ligase HUWE1 isoform X9

      UniProtKB/TrEMBL
      A0A994J483

    28. XM_047441720.1 → XP_047297676.1  E3 ubiquitin-protein ligase HUWE1 isoform X7

      UniProtKB/TrEMBL
      A0A994J483

    29. XM_047441718.1 → XP_047297674.1  E3 ubiquitin-protein ligase HUWE1 isoform X5

      UniProtKB/TrEMBL
      A0A994J483

    30. XM_047441712.1 → XP_047297668.1  E3 ubiquitin-protein ligase HUWE1 isoform X2

      UniProtKB/TrEMBL
      A0A994J483

    31. XM_047441749.1 → XP_047297705.1  E3 ubiquitin-protein ligase HUWE1 isoform X24

      UniProtKB/TrEMBL
      A0A994J483

    32. XM_047441748.1 → XP_047297704.1  E3 ubiquitin-protein ligase HUWE1 isoform X23

      UniProtKB/TrEMBL
      A0A994J483

    33. XM_047441746.1 → XP_047297702.1  E3 ubiquitin-protein ligase HUWE1 isoform X21

      UniProtKB/TrEMBL
      A0A994J483

    34. XM_047441726.1 → XP_047297682.1  E3 ubiquitin-protein ligase HUWE1 isoform X13

      UniProtKB/TrEMBL
      A0A994J483

    35. XM_047441725.1 → XP_047297681.1  E3 ubiquitin-protein ligase HUWE1 isoform X12

      UniProtKB/TrEMBL
      A0A994J483

    36. XM_047441723.1 → XP_047297679.1  E3 ubiquitin-protein ligase HUWE1 isoform X10

      UniProtKB/TrEMBL
      A0A994J483

    37. XM_047441721.1 → XP_047297677.1  E3 ubiquitin-protein ligase HUWE1 isoform X8

      UniProtKB/TrEMBL
      A0A994J483

    38. XM_047441719.1 → XP_047297675.1  E3 ubiquitin-protein ligase HUWE1 isoform X6

      UniProtKB/TrEMBL
      A0A994J483

    39. XM_047441717.1 → XP_047297673.1  E3 ubiquitin-protein ligase HUWE1 isoform X4

      UniProtKB/TrEMBL
      A0A994J483

    40. XM_017029198.3 → XP_016884687.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

      UniProtKB/TrEMBL
      A0A994J483

    41. XM_047441745.1 → XP_047297701.1  E3 ubiquitin-protein ligase HUWE1 isoform X20

      UniProtKB/TrEMBL
      A0A994J483

    42. XM_047441737.1 → XP_047297693.1  E3 ubiquitin-protein ligase HUWE1 isoform X17

      UniProtKB/TrEMBL
      A0A994J483

    43. XM_047441731.1 → XP_047297687.1  E3 ubiquitin-protein ligase HUWE1 isoform X16

      UniProtKB/Swiss-Prot
      O15029, Q4G2Z2, Q5H961, Q6P4D0, Q7Z6Z7, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9
      UniProtKB/TrEMBL
      A0A994J483
      Related
      ENSP00000479451.1, ENST00000612484.4

    44. XM_011530751.3 → XP_011529053.1  E3 ubiquitin-protein ligase HUWE1 isoform X3

      See identical proteins and their annotated locations for XP_011529053.1

      UniProtKB/TrEMBL
      A0A994J483
      Conserved Domains (7) summary
      cd00078
      Location:4102 → 4455
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1400 → 1439
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
      pfam02825
      Location:1700 → 1761
      WWE; WWE domain
      pfam06012
      Location:92 → 367
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:430 → 897
      DUF913; Domain of Unknown Function (DUF913)
      pfam14377
      Location:3051 → 3160
      DUF4414; Domain of unknown function (DUF4414)
      cl26464
      Location:2818 → 3149
      Atrophin-1; Atrophin-1 family

    45. XM_017029203.2 → XP_016884692.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

      UniProtKB/TrEMBL
      A0A994J483

    46. XM_047441733.1 → XP_047297689.1  E3 ubiquitin-protein ligase HUWE1 isoform X16

      UniProtKB/Swiss-Prot
      O15029, Q4G2Z2, Q5H961, Q6P4D0, Q7Z6Z7, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9
      UniProtKB/TrEMBL
      A0A994J483

    47. XM_047441715.1 → XP_047297671.1  E3 ubiquitin-protein ligase HUWE1 isoform X3

      UniProtKB/TrEMBL
      A0A994J483

    48. XM_047441711.1 → XP_047297667.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

      UniProtKB/TrEMBL
      A0A994J483

    49. XM_047441716.1 → XP_047297672.1  E3 ubiquitin-protein ligase HUWE1 isoform X3

      UniProtKB/TrEMBL
      A0A994J483

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      52818443..52973077 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054326321.1 → XP_054182296.1  E3 ubiquitin-protein ligase HUWE1 isoform X20

      UniProtKB/TrEMBL
      A0A994J483

    2. XM_054326310.1 → XP_054182285.1  E3 ubiquitin-protein ligase HUWE1 isoform X17

      UniProtKB/TrEMBL
      A0A994J483

    3. XM_054326328.1 → XP_054182303.1  E3 ubiquitin-protein ligase HUWE1 isoform X25

      UniProtKB/TrEMBL
      A0A994J483

    4. XM_054326318.1 → XP_054182293.1  E3 ubiquitin-protein ligase HUWE1 isoform X19

      UniProtKB/TrEMBL
      A0A994J483

    5. XM_054326287.1 → XP_054182262.1  E3 ubiquitin-protein ligase HUWE1 isoform X3

      UniProtKB/TrEMBL
      A0A994J483

    6. XM_054326316.1 → XP_054182291.1  E3 ubiquitin-protein ligase HUWE1 isoform X18

      UniProtKB/TrEMBL
      A0A994J483

    7. XM_054326304.1 → XP_054182279.1  E3 ubiquitin-protein ligase HUWE1 isoform X15

      UniProtKB/TrEMBL
      A0A994J483

    8. XM_054326281.1 → XP_054182256.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

      UniProtKB/TrEMBL
      A0A994J483

    9. XM_054326312.1 → XP_054182287.1  E3 ubiquitin-protein ligase HUWE1 isoform X17

      UniProtKB/TrEMBL
      A0A994J483

    10. XM_054326319.1 → XP_054182294.1  E3 ubiquitin-protein ligase HUWE1 isoform X19

      UniProtKB/TrEMBL
      A0A994J483

    11. XM_054326307.1 → XP_054182282.1  E3 ubiquitin-protein ligase HUWE1 isoform X16

      UniProtKB/Swiss-Prot
      O15029, Q4G2Z2, Q5H961, Q6P4D0, Q7Z6Z7, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9
      UniProtKB/TrEMBL
      A0A994J483

    12. XM_054326288.1 → XP_054182263.1  E3 ubiquitin-protein ligase HUWE1 isoform X3

      UniProtKB/TrEMBL
      A0A994J483

    13. XM_054326305.1 → XP_054182280.1  E3 ubiquitin-protein ligase HUWE1 isoform X15

      UniProtKB/TrEMBL
      A0A994J483

    14. XM_054326282.1 → XP_054182257.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

      UniProtKB/TrEMBL
      A0A994J483

    15. XM_054326309.1 → XP_054182284.1  E3 ubiquitin-protein ligase HUWE1 isoform X16

      UniProtKB/Swiss-Prot
      O15029, Q4G2Z2, Q5H961, Q6P4D0, Q7Z6Z7, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9
      UniProtKB/TrEMBL
      A0A994J483

    16. XM_054326291.1 → XP_054182266.1  E3 ubiquitin-protein ligase HUWE1 isoform X3

      UniProtKB/TrEMBL
      A0A994J483

    17. XM_054326285.1 → XP_054182260.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

      UniProtKB/TrEMBL
      A0A994J483

    18. XM_054326329.1 → XP_054182304.1  E3 ubiquitin-protein ligase HUWE1 isoform X26

      UniProtKB/TrEMBL
      A0A994J483

    19. XM_054326320.1 → XP_054182295.1  E3 ubiquitin-protein ligase HUWE1 isoform X20

      UniProtKB/TrEMBL
      A0A994J483

    20. XM_054326311.1 → XP_054182286.1  E3 ubiquitin-protein ligase HUWE1 isoform X17

      UniProtKB/TrEMBL
      A0A994J483

    21. XM_054326327.1 → XP_054182302.1  E3 ubiquitin-protein ligase HUWE1 isoform X25

      UniProtKB/TrEMBL
      A0A994J483

    22. XM_054326317.1 → XP_054182292.1  E3 ubiquitin-protein ligase HUWE1 isoform X19

      UniProtKB/TrEMBL
      A0A994J483

    23. XM_054326315.1 → XP_054182290.1  E3 ubiquitin-protein ligase HUWE1 isoform X18

      UniProtKB/TrEMBL
      A0A994J483

    24. XM_054326303.1 → XP_054182278.1  E3 ubiquitin-protein ligase HUWE1 isoform X15

      UniProtKB/TrEMBL
      A0A994J483

    25. XM_054326324.1 → XP_054182299.1  E3 ubiquitin-protein ligase HUWE1 isoform X22

      UniProtKB/TrEMBL
      A0A994J483

    26. XM_054326302.1 → XP_054182277.1  E3 ubiquitin-protein ligase HUWE1 isoform X14

      UniProtKB/TrEMBL
      A0A994J483

    27. XM_054326299.1 → XP_054182274.1  E3 ubiquitin-protein ligase HUWE1 isoform X11

      UniProtKB/TrEMBL
      A0A994J483

    28. XM_054326297.1 → XP_054182272.1  E3 ubiquitin-protein ligase HUWE1 isoform X9

      UniProtKB/TrEMBL
      A0A994J483

    29. XM_054326295.1 → XP_054182270.1  E3 ubiquitin-protein ligase HUWE1 isoform X7

      UniProtKB/TrEMBL
      A0A994J483

    30. XM_054326293.1 → XP_054182268.1  E3 ubiquitin-protein ligase HUWE1 isoform X5

      UniProtKB/TrEMBL
      A0A994J483

    31. XM_054326286.1 → XP_054182261.1  E3 ubiquitin-protein ligase HUWE1 isoform X2

      UniProtKB/TrEMBL
      A0A994J483

    32. XM_054326326.1 → XP_054182301.1  E3 ubiquitin-protein ligase HUWE1 isoform X24

      UniProtKB/TrEMBL
      A0A994J483

    33. XM_054326325.1 → XP_054182300.1  E3 ubiquitin-protein ligase HUWE1 isoform X23

      UniProtKB/TrEMBL
      A0A994J483

    34. XM_054326323.1 → XP_054182298.1  E3 ubiquitin-protein ligase HUWE1 isoform X21

      UniProtKB/TrEMBL
      A0A994J483

    35. XM_054326301.1 → XP_054182276.1  E3 ubiquitin-protein ligase HUWE1 isoform X13

      UniProtKB/TrEMBL
      A0A994J483

    36. XM_054326300.1 → XP_054182275.1  E3 ubiquitin-protein ligase HUWE1 isoform X12

      UniProtKB/TrEMBL
      A0A994J483

    37. XM_054326298.1 → XP_054182273.1  E3 ubiquitin-protein ligase HUWE1 isoform X10

      UniProtKB/TrEMBL
      A0A994J483

    38. XM_054326296.1 → XP_054182271.1  E3 ubiquitin-protein ligase HUWE1 isoform X8

      UniProtKB/TrEMBL
      A0A994J483

    39. XM_054326294.1 → XP_054182269.1  E3 ubiquitin-protein ligase HUWE1 isoform X6

      UniProtKB/TrEMBL
      A0A994J483

    40. XM_054326292.1 → XP_054182267.1  E3 ubiquitin-protein ligase HUWE1 isoform X4

      UniProtKB/TrEMBL
      A0A994J483

    41. XM_054326322.1 → XP_054182297.1  E3 ubiquitin-protein ligase HUWE1 isoform X20

      UniProtKB/TrEMBL
      A0A994J483

    42. XM_054326314.1 → XP_054182289.1  E3 ubiquitin-protein ligase HUWE1 isoform X17

      UniProtKB/TrEMBL
      A0A994J483

    43. XM_054326306.1 → XP_054182281.1  E3 ubiquitin-protein ligase HUWE1 isoform X16

      UniProtKB/Swiss-Prot
      O15029, Q4G2Z2, Q5H961, Q6P4D0, Q7Z6Z7, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9
      UniProtKB/TrEMBL
      A0A994J483

    44. XM_054326289.1 → XP_054182264.1  E3 ubiquitin-protein ligase HUWE1 isoform X3

      UniProtKB/TrEMBL
      A0A994J483

    45. XM_054326308.1 → XP_054182283.1  E3 ubiquitin-protein ligase HUWE1 isoform X16

      UniProtKB/Swiss-Prot
      O15029, Q4G2Z2, Q5H961, Q6P4D0, Q7Z6Z7, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9
      UniProtKB/TrEMBL
      A0A994J483

    46. XM_054326284.1 → XP_054182259.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

      UniProtKB/TrEMBL
      A0A994J483

    47. XM_054326283.1 → XP_054182258.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

      UniProtKB/TrEMBL
      A0A994J483

    48. XM_054326313.1 → XP_054182288.1  E3 ubiquitin-protein ligase HUWE1 isoform X17

      UniProtKB/TrEMBL
      A0A994J483

    49. XM_054326290.1 → XP_054182265.1  E3 ubiquitin-protein ligase HUWE1 isoform X3

      UniProtKB/TrEMBL
      A0A994J483
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7Z6Z7.3 GenPept UniProtKB/Swiss-Prot:Q7Z6Z7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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