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Envelope surface glycoprotein gp120
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env
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Tandem affinity purification and mass spectrometry analysis identify Moloney leukemia virus 10 homolog (MOV10), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells |
PubMed
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Gag-Pol
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gag-pol
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Tandem affinity purification and mass spectrometry analysis identify Moloney leukemia virus 10 homolog (MOV10), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells |
PubMed
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Nef
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nef
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Tandem affinity purification and mass spectrometry analysis identify Moloney leukemia virus 10 homolog (MOV10), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells |
PubMed
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Pr55(Gag)
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gag
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siRNA-mediated knockdown of endogeneous MOV10 impairs HIV-1 virus production and Gag expression in 293T cells |
PubMed
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gag
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Tandem affinity purification and mass spectrometry analysis identify Moloney leukemia virus 10 homolog (MOV10), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells |
PubMed
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gag
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Overexpression of the Mov10 mutants, G681A/D682A and R730A/N731A, impairs Mov10-mediated decrease of HIV-1 Gag expression in cells and the incorporation efficiency of Mov10 into particles |
PubMed
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gag
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The efficiency of incorporation of Mov10, A3G, and A3F into viral particles, which contains both HIV-1 Gag and genomic RNA, is much higher than that of the other P-body proteins AGO2, DCP1a, DCP2, and DDX6 |
PubMed
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gag
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Mov10 overexpression results in translational repression of HIV-1 Gag and that AGO2 and/or RISC function is required to induce this translational repression |
PubMed
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gag
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Overexpression of A3G and Mov10 decreases the efficiency of HIV-1 Gag processing in the virus-producing cells |
PubMed
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gag
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MOV10 is packaged into HIV-1 virions in an RNA-dependent manner via an interaction with the NC domain of Gag |
PubMed
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gag
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HIV-1 Gag binds to the N-terminal amino acids 261-305 region of MOV10. The seven helicase motifs of MOV10 are not required for its interaction with Gag, while all but one of them (motif V) are required for MOV10 packaging into virions |
PubMed
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Rev
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rev
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HIV-1 Rev requires MOV10 helicase activity for enhanced function |
PubMed
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rev
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HIV-1 Rev interacts with Rev |
PubMed
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rev
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Rev/RRE expression is specifically upregulated by MOV10 in a Rev/RRE-dependent reprter gene assay |
PubMed
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nucleocapsid
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gag
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MOV10 is packaged into HIV-1 virions in an RNA-dependent manner via an interaction with the NC domain of Gag |
PubMed
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