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    Calx Na/Ca-exchange protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42481, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Calxprovided by FlyBase
    Official Full Name
    Na/Ca-exchange proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0013995
    Locus tag
    Dmel_CG5685
    See related
    AllianceGenome:FB:FBgn0013995
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    9C5; anon-93ABa; calx; calX; CalX; CALX; CALX1.1; CG5685; Dmel/Ncx; Dmel\CG5685; Ncx; NCX
    Summary
    Enables calcium ion binding activity and calcium:sodium antiporter activity. Involved in neuromuscular process controlling posture and phototransduction. Predicted to be located in membrane. Predicted to be active in axon; postsynapse; and sarcolemma. Is expressed in several structures, including adult brain; adult head; adult heart; anlage in statu nascendi; and antennal anlage. Human ortholog(s) of this gene implicated in hypertension. Orthologous to several human genes including SLC8A2 (solute carrier family 8 member A2) and SLC8A3 (solute carrier family 8 member A3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Calx in Genome Data Viewer
    Location:
    93A4-93B3; 3-70 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (20978183..21015613)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (16803905..16841335)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene hadley Neighboring gene Na pump alpha subunit Neighboring gene uncharacterized protein Neighboring gene Alkaline phosphatase 5 Neighboring gene uncharacterized protein Neighboring gene Ral interacting protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional differences in ionic regulation between alternatively spliced isoforms of the Na+-Ca2+ exchanger from Drosophila melanogaster. Omelchenko A, et al. J Gen Physiol, 1998 May. PMID 9565406, Free PMC Article
    2. Crystal structure of CBD2 from the Drosophila Na(+)/Ca(2+) exchanger: diversity of Ca(2+) regulation and its alternative splicing modification. Wu M, et al. J Mol Biol, 2009 Mar 20. PMID 19361442
    3. Crystal structures of progressive Ca2+ binding states of the Ca2+ sensor Ca2+ binding domain 1 (CBD1) from the CALX Na+/Ca2+ exchanger reveal incremental conformational transitions. Wu M, et al. J Biol Chem, 2010 Jan 22. PMID 19815561, Free PMC Article
    4. Structural basis of the Ca2+ inhibitory mechanism of Drosophila Na+/Ca2+ exchanger CALX and its modification by alternative splicing. Wu M, et al. Structure, 2011 Oct 12. PMID 22000518, Free PMC Article
    5. Calx, a sodium/calcium exchanger, may affect lifespan in Drosophila melanogaster. Mok JW, et al. MicroPubl Biol, 2020 Feb 12. PMID 32550491, Free PMC Article

    See all (105) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CALX-CBD1 Ca(2+)-Binding Cooperativity Studied by NMR Spectroscopy and ITC with Bayesian Statistics.
      Title: CALX-CBD1 Ca(2+)-Binding Cooperativity Studied by NMR Spectroscopy and ITC with Bayesian Statistics.
    2. Structural studies of the Ca(2+) regulatory domain of Drosophila Na(+)/Ca (2+) exchanger CALX.
      Title: Structural studies of the Ca(2+) regulatory domain of Drosophila Na(+)/Ca (2+) exchanger CALX.
    3. Ca(2+) inhibition of CALX is achieved by interdomain conformational changes induced by Ca(2+) binding at the CBD1 regulatory domain.
      Title: Structural basis of the Ca2+ inhibitory mechanism of Drosophila Na+/Ca2+ exchanger CALX and its modification by alternative splicing.
    4. Ca(2+) binding only enhances the stability of the Ca(2+) binding site of CBD1 near the hinge region while the overall structure of CBD1 remains largely unaffected for calx
      Title: Crystal structures of progressive Ca2+ binding states of the Ca2+ sensor Ca2+ binding domain 1 (CBD1) from the CALX Na+/Ca2+ exchanger reveal incremental conformational transitions.
    5. results provide evidence that the diversity of Ca(2+) regulatory properties of NCX proteins can be achieved by (1) local structure rearrangement of Ca(2+) binding site to change Ca(2+) binding properties of CBD2 and (2) alternative splicing variation
      Title: Crystal structure of CBD2 from the Drosophila Na(+)/Ca(2+) exchanger: diversity of Ca(2+) regulation and its alternative splicing modification.
    6. Loss of CalX caused a transient response to light, an increase in signal amplification, and rapid adaptation. Conversely, overexpression of CalX suppressed the retinal degeneration caused by activity of the TRP channel.
      Title: Light activation, adaptation, and cell survival functions of the Na+/Ca2+ exchanger CalX.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calcium:sodium antiporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium:sodium antiporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calcium:sodium antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium:sodium antiporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables calcium:sodium antiporter activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in calcium ion import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in calcium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell communication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neuromuscular process controlling posture IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phototransduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to endoplasmic reticulum stress HMP PubMed 
    involved_in sodium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in postsynapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in sarcolemma IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Na/Ca-exchange protein
    Names
    CG5685-PA
    CG5685-PB
    CG5685-PC
    CG5685-PD
    CG5685-PE
    CG5685-PF
    CG5685-PG
    CG5685-PH
    CG5685-PI
    Calx-PA
    Calx-PB
    Calx-PC
    Calx-PD
    Calx-PE
    Calx-PF
    Calx-PG
    Calx-PH
    Calx-PI

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      20978183..21015613
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001260286.2 → NP_001247215.1  Na/Ca-exchange protein, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247215.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K6E2, O18367
      Conserved Domains (4) summary
      smart00237
      Location:441 → 529
      Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
      TIGR00845
      Location:4 → 973
      caca; sodium/calcium exchanger 1
      pfam01699
      Location:800 → 965
      Na_Ca_ex; Sodium/calcium exchanger protein
      pfam16494
      Location:300 → 414
      Na_Ca_ex_C; C-terminal extension of sodium/calcium exchanger domain

    2. NM_079699.4 → NP_524423.2  Na/Ca-exchange protein, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524423.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A0B4K6R7, Q24413, Q9VDG5
      UniProtKB/TrEMBL
      O18367
      Related
      FBpp0083402
      Conserved Domains (4) summary
      smart00237
      Location:441 → 529
      Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
      TIGR00845
      Location:4 → 950
      caca; sodium/calcium exchanger 1
      pfam01699
      Location:777 → 942
      Na_Ca_ex; Sodium/calcium exchanger protein
      pfam16494
      Location:300 → 414
      Na_Ca_ex_C; C-terminal extension of sodium/calcium exchanger domain

    3. NM_001260285.2 → NP_001247214.1  Na/Ca-exchange protein, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247214.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K6A6, O18367
      Conserved Domains (4) summary
      smart00237
      Location:441 → 529
      Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
      TIGR00845
      Location:4 → 960
      caca; sodium/calcium exchanger 1
      pfam01699
      Location:787 → 952
      Na_Ca_ex; Sodium/calcium exchanger protein
      pfam16494
      Location:300 → 414
      Na_Ca_ex_C; C-terminal extension of sodium/calcium exchanger domain

    4. NM_169940.4 → NP_732576.1  Na/Ca-exchange protein, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732576.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A0B4K6R7, Q24413, Q9VDG5
      UniProtKB/TrEMBL
      O18367
      Related
      FBpp0083403
      Conserved Domains (4) summary
      smart00237
      Location:441 → 529
      Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
      TIGR00845
      Location:4 → 950
      caca; sodium/calcium exchanger 1
      pfam01699
      Location:777 → 942
      Na_Ca_ex; Sodium/calcium exchanger protein
      pfam16494
      Location:300 → 414
      Na_Ca_ex_C; C-terminal extension of sodium/calcium exchanger domain

    5. NM_001260284.2 → NP_001247213.1  Na/Ca-exchange protein, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247213.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K790, O18367
      Conserved Domains (4) summary
      smart00237
      Location:441 → 529
      Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
      TIGR00845
      Location:4 → 963
      caca; sodium/calcium exchanger 1
      pfam01699
      Location:790 → 955
      Na_Ca_ex; Sodium/calcium exchanger protein
      pfam16494
      Location:300 → 414
      Na_Ca_ex_C; C-terminal extension of sodium/calcium exchanger domain

    6. NM_001300506.1 → NP_001287435.1  Na/Ca-exchange protein, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287435.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LHD9
      Conserved Domains (3) summary
      smart00237
      Location:441 → 529
      Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
      pfam01699
      Location:126 → 297
      Na_Ca_ex; Sodium/calcium exchanger protein
      pfam16494
      Location:300 → 414
      Na_Ca_ex_C; C-terminal extension of sodium/calcium exchanger domain

    7. NM_001300505.1 → NP_001287434.1  Na/Ca-exchange protein, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287434.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LHD7, O18367
      Conserved Domains (4) summary
      smart00237
      Location:441 → 529
      Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
      TIGR00845
      Location:4 → 955
      caca; sodium/calcium exchanger 1
      pfam01699
      Location:782 → 947
      Na_Ca_ex; Sodium/calcium exchanger protein
      pfam16494
      Location:300 → 414
      Na_Ca_ex_C; C-terminal extension of sodium/calcium exchanger domain

    8. NM_169941.2 → NP_732577.1  Na/Ca-exchange protein, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732577.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A0B4K6R7, Q24413, Q9VDG5
      UniProtKB/TrEMBL
      O18367
      Related
      FBpp0083404
      Conserved Domains (4) summary
      smart00237
      Location:441 → 529
      Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
      TIGR00845
      Location:4 → 950
      caca; sodium/calcium exchanger 1
      pfam01699
      Location:777 → 942
      Na_Ca_ex; Sodium/calcium exchanger protein
      pfam16494
      Location:300 → 414
      Na_Ca_ex_C; C-terminal extension of sodium/calcium exchanger domain

    9. NM_001260283.2 → NP_001247212.1  Na/Ca-exchange protein, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247212.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O18367
      Conserved Domains (4) summary
      smart00237
      Location:441 → 529
      Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
      TIGR00845
      Location:4 → 950
      caca; sodium/calcium exchanger 1
      pfam01699
      Location:777 → 942
      Na_Ca_ex; Sodium/calcium exchanger protein
      pfam16494
      Location:300 → 414
      Na_Ca_ex_C; C-terminal extension of sodium/calcium exchanger domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K6A6 A0A0B4K6A6
    A0A0B4K6E2 A0A0B4K6E2
    A0A0B4K6R7 A0A0B4K6R7
    A0A0B4K790 A0A0B4K790
    A0A0B4LHD7 A0A0B4LHD7
    A0A0B4LHD9 A0A0B4LHD9
    O18367 O18367
    Q24413 Q24413
    Q9VDG5 Q9VDG5
    Q9VDG5.1

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