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    BTBD9 BTB (POZ) domain containing 9 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32000, updated on 9-Dec-2024

    Summary

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    Official Symbol
    BTBD9provided by FlyBase
    Official Full Name
    BTB (POZ) domain containing 9provided by FlyBase
    Primary source
    FLYBASE:FBgn0030228
    Locus tag
    Dmel_CG1826
    See related
    AllianceGenome:FB:FBgn0030228
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1826; dBTBD9; Dmel\CG1826
    Summary
    Involved in adult locomotory behavior; positive regulation of circadian sleep/wake cycle, sleep; and regulation of dopaminergic synaptic transmission. Located in cytoplasm. Is expressed in organism. Used to study restless legs syndrome. Orthologous to human BTBD9 (BTB domain containing 9). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See BTBD9 in Genome Data Viewer
    Location:
    9E7-9E8; 1-32 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (10768537..10772154)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (10662570..10666187)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Transport and Golgi organization 5 Neighboring gene Autophagy-related 8a Neighboring gene uncharacterized protein Neighboring gene Adenine nucleotide translocase 2 Neighboring gene stress-sensitive B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sleep fragmentation and motor restlessness in a Drosophila model of Restless Legs Syndrome. Freeman A, et al. Curr Biol, 2012 Jun 19. PMID 22658601, Free PMC Article
    2. The Molecular Genetics of Restless Legs Syndrome. Rye DB. Sleep Med Clin, 2015 Sep. PMID 26329432
    3. Drosophila and genome-wide association studies: a review and resource for the functional dissection of human complex traits. Wangler MF, et al. Dis Model Mech, 2017 Feb 1. PMID 28151408, Free PMC Article
    4. Using High-Throughput Animal or Cell-Based Models to Functionally Characterize GWAS Signals. Dourlen P, et al. Curr Genet Med Rep, 2018. PMID 30147999, Free PMC Article
    5. Modeling the genetic basis for human sleep disorders in Drosophila. Freeman AA, et al. Commun Integr Biol, 2013 Jan 1. PMID 23802043, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Restless Legs Syndrome risk factor BTBD9 (CG1826) regulates sleep, dopamine levels, and iron homeostasis in Drosophila.
      Title: Sleep fragmentation and motor restlessness in a Drosophila model of Restless Legs Syndrome.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in adult locomotory behavior IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in adult locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in circadian behavior IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in modulation of chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of circadian sleep/wake cycle, sleep IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of synaptic transmission, dopaminergic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    BTB (POZ) domain containing 9
    Names
    BTB (POZ) domain containing 9 ortholog
    BTBD9-PA
    BTBD9-PB
    CG1826-PA
    CG1826-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      10768537..10772154
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132421.3 → NP_572649.1  BTB (POZ) domain containing 9, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572649.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9W2S3
      Related
      FBpp0071426
      Conserved Domains (5) summary
      smart00225
      Location:47 → 145
      BTB; Broad-Complex, Tramtrack and Bric a brac
      cd14822
      Location:145 → 203
      BACK_BTBD9_like; BACK-like Domain C-terminal to BTB in BTB/POZ domain-containing protein 9 and similar proteins
      pfam00651
      Location:42 → 141
      BTB; BTB/POZ domain
      pfam00754
      Location:451 → 554
      F5_F8_type_C; F5/8 type C domain
      cl23730
      Location:299 → 399
      F5_F8_type_C; F5/8 type C domain

    2. NM_001272502.1 → NP_001259431.1  BTB (POZ) domain containing 9, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259431.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9W2S3
      Conserved Domains (5) summary
      smart00225
      Location:47 → 145
      BTB; Broad-Complex, Tramtrack and Bric a brac
      cd14822
      Location:145 → 203
      BACK_BTBD9_like; BACK-like Domain C-terminal to BTB in BTB/POZ domain-containing protein 9 and similar proteins
      pfam00651
      Location:42 → 141
      BTB; BTB/POZ domain
      pfam00754
      Location:451 → 554
      F5_F8_type_C; F5/8 type C domain
      cl23730
      Location:299 → 399
      F5_F8_type_C; F5/8 type C domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W2S3.1 Q9W2S3

    Gene LinkOut

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