CG30122 uncharacterized protein [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: CG30122provided by FlyBase
Official Full Name: uncharacterized proteinprovided by FlyBase
Primary source: FLYBASE:FBgn0050122
Locus tag: Dmel_CG30122
See related: AllianceGenome:FB:FBgn0050122
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG18610; cg30122; CG5477; Dmel\CG30122; hnRNP U; HNRNPU1; LD11002; SAF-A
Summary: Predicted to enable RNA binding activity. Predicted to be involved in alternative mRNA splicing, via spliceosome. Part of precatalytic spliceosome. Is expressed in several structures, including adult head; adult heart; central brain primordium; ganglia; and spermatozoon. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 54. Orthologous to several human genes including HNRNPU (heterogeneous nuclear ribonucleoprotein U) and HNRNPUL2 (heterogeneous nuclear ribonucleoprotein U like 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 55E3-55E3; 2-86 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (18632328..18639270, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (14519833..14526775, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in alternative mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA splicing, via spliceosome	IC Inferred by Curator more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of precatalytic spliceosome	HDA more info	PubMed

General protein information

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Preferred Names: uncharacterized protein

Names: CG30122-PB; CG30122-PC; CG30122-PD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

18632328..18639270 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_137510.4 → NP_611354.2 uncharacterized protein Dmel_CG30122, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_611354.2

Status: REVIEWED

UniProtKB/TrEMBL

A1ZBB4, C7LAA5

Related

FBpp0085841

Conserved Domains (6) summary

PHA02664
Location:529 → 659

PHA02664; hypothetical protein; Provisional

pfam02037
Location:6 → 40

SAP; SAP domain

pfam08648
Location:1033 → 1104

DUF1777; Protein of unknown function (DUF1777)

pfam13671
Location:709 → 855

AAA_33; AAA domain

cd12884
Location:300 → 480

SPRY_hnRNP; SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1

cl17190
Location:709 → 836

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
NM_001169726.2 → NP_001163197.1 uncharacterized protein Dmel_CG30122, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163197.1

Status: REVIEWED

UniProtKB/TrEMBL

A8E6M1, C7LAA5

Conserved Domains (6) summary

PHA02664
Location:529 → 659

PHA02664; hypothetical protein; Provisional

pfam02037
Location:6 → 40

SAP; SAP domain

pfam08648
Location:1033 → 1104

DUF1777; Protein of unknown function (DUF1777)

pfam13671
Location:709 → 855

AAA_33; AAA domain

cd12884
Location:300 → 480

SPRY_hnRNP; SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1

cl17190
Location:709 → 836

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
NM_001169725.2 → NP_001163196.1 uncharacterized protein Dmel_CG30122, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163196.1

Status: REVIEWED

UniProtKB/TrEMBL

C7LAA5, E1JGL8

Conserved Domains (6) summary

PHA02664
Location:529 → 659

PHA02664; hypothetical protein; Provisional

pfam02037
Location:6 → 40

SAP; SAP domain

pfam08648
Location:1033 → 1104

DUF1777; Protein of unknown function (DUF1777)

pfam13671
Location:709 → 855

AAA_33; AAA domain

cd12884
Location:300 → 480

SPRY_hnRNP; SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1

cl17190
Location:709 → 836

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...