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    Pisd Phosphatidylserine decarboxylase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42849, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pisdprovided by FlyBase
    Official Full Name
    Phosphatidylserine decarboxylaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0026576
    Locus tag
    Dmel_CG5991
    See related
    AllianceGenome:FB:FBgn0026576
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BEST:LD21713; CG5991; Dmel\CG5991; LD21713; Psd
    Summary
    Enables phosphatidylserine decarboxylase activity. Involved in phosphatidylethanolamine biosynthetic process. Is active in mitochondrial inner membrane. Is expressed in adult head and organism. Used to study retinal disease. Orthologous to human PISD (phosphatidylserine decarboxylase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Pisd in Genome Data Viewer
    Location:
    95D10-95D10; 3-82 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (24050783..24053592)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (19876505..19879314)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Rox8 Neighboring gene uncharacterized protein Neighboring gene Autophagy-related 6 Neighboring gene long non-coding RNA:CR44097 Neighboring gene uncharacterized protein Neighboring gene Heat shock protein 68 Neighboring gene Structural maintenance of chromosomes 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Fat body phospholipid state dictates hunger-driven feeding behavior. Kelly KP, et al. Elife, 2022 Oct 6. PMID 36201241, Free PMC Article
    2. The one-carbon pool controls mitochondrial energy metabolism via complex I and iron-sulfur clusters. Rosenberger FA, et al. Sci Adv, 2021 Feb. PMID 33608280, Free PMC Article
    3. Phosphatidylserine synthase regulates cellular homeostasis through distinct metabolic mechanisms. Yang X, et al. PLoS Genet, 2019 Dec. PMID 31869331, Free PMC Article
    4. Myosin VI plays a role in cell-cell adhesion during epithelial morphogenesis. Millo H, et al. Mech Dev, 2004 Nov. PMID 15454264
    5. Autophagy-dependent rhodopsin degradation prevents retinal degeneration in Drosophila. Midorikawa R, et al. J Neurosci, 2010 Aug 11. PMID 20702701, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables phosphatidylserine decarboxylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylserine decarboxylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylserine decarboxylase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in phosphatidylethanolamine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylethanolamine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phospholipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    phosphatidylserine decarboxylase
    Names
    CG5991-PA
    CG5991-PB
    CG5991-PC
    Pisd-PA
    Pisd-PB
    Pisd-PC
    NP_651208.1
    NP_732948.1
    NP_732949.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      24050783..24053592
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142951.3 → NP_651208.1  phosphatidylserine decarboxylase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651208.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C6TPB6, Q9VCE0
      Related
      FBpp0083921
      Conserved Domains (2) summary
      PLN02938
      Location:61 → 441
      PLN02938; phosphatidylserine decarboxylase
      cl03656
      Location:180 → 443
      PS_Dcarbxylase; Phosphatidylserine decarboxylase

    2. NM_170121.2 → NP_732949.1  phosphatidylserine decarboxylase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732949.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C6TPB6, Q9VCE0
      Related
      FBpp0083922
      Conserved Domains (2) summary
      PLN02938
      Location:61 → 441
      PLN02938; phosphatidylserine decarboxylase
      cl03656
      Location:180 → 443
      PS_Dcarbxylase; Phosphatidylserine decarboxylase

    3. NM_170120.2 → NP_732948.1  phosphatidylserine decarboxylase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732948.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C6TPB6, Q9VCE0
      Related
      FBpp0083923
      Conserved Domains (2) summary
      PLN02938
      Location:61 → 441
      PLN02938; phosphatidylserine decarboxylase
      cl03656
      Location:180 → 443
      PS_Dcarbxylase; Phosphatidylserine decarboxylase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VCE0 Q9VCE0

    Gene LinkOut

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