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    Atp1b1 ATPase, Na+/K+ transporting, beta 1 polypeptide [ Mus musculus (house mouse) ]

    Gene ID: 11931, updated on 9-Dec-2024

    Summary

    Official Symbol
    Atp1b1provided by MGI
    Official Full Name
    ATPase, Na+/K+ transporting, beta 1 polypeptideprovided by MGI
    Primary source
    MGI:MGI:88108
    See related
    Ensembl:ENSMUSG00000026576 AllianceGenome:MGI:88108
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Atpb; Atp4b; Atpb-1; NKbeta1
    Summary
    This gene encodes an integral membrane protein that comprises a subunit of an ATP-metabolizing enzyme responsible for transporting sodium and potassium ions across the plasma membrane. This enzyme regulates the electrochemical gradient of these ions in cells, and plays a central role in osmoregulation and signal transmission in nerves and muscles, among other biological processes. The encoded protein is the non-catalytic beta subunit; it works together with a catalytic alpha subunit and a gamma subunit. [provided by RefSeq, Mar 2013]
    Expression
    Biased expression in cerebellum adult (RPKM 397.4), kidney adult (RPKM 397.3) and 13 other tissues See more
    Orthologs
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    Genomic context

    See Atp1b1 in Genome Data Viewer
    Location:
    1 H2.2; 1 71.75 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (164264668..164285924, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (164437099..164458355, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E797 Neighboring gene basic leucine zipper nuclear factor 1 Neighboring gene NME/NM23 family member 7 Neighboring gene STARR-positive B cell enhancer ABC_E5840 Neighboring gene STARR-seq mESC enhancer starr_02870 Neighboring gene predicted gene, 39690 Neighboring gene predicted gene, 32391 Neighboring gene predicted gene, 39691

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATPase activator activity  
    enables ATPase activator activity PubMed 
    enables ATPase activator activity  
    enables ATPase binding  
    enables ATPase binding  
    enables P-type sodium:potassium-exchanging transporter activity  
    enables P-type sodium:potassium-exchanging transporter activity  
    enables protein binding PubMed 
    enables protein heterodimerization activity  
    enables protein kinase binding PubMed 
    enables protein-macromolecule adaptor activity  
    enables protein-macromolecule adaptor activity  
    Items 1 - 25 of 41
    Process Evidence Code Pubs
    involved_in ATP metabolic process  
    involved_in ATP metabolic process  
    acts_upstream_of_or_within blastocyst development  
    involved_in cardiac muscle contraction PubMed 
    involved_in cell adhesion  
    involved_in establishment or maintenance of transmembrane electrochemical gradient PubMed 
    involved_in intracellular calcium ion homeostasis PubMed 
    involved_in intracellular potassium ion homeostasis  
    involved_in intracellular potassium ion homeostasis  
    involved_in intracellular sodium ion homeostasis  
    involved_in intracellular sodium ion homeostasis  
    involved_in membrane repolarization  
    involved_in membrane repolarization  
    involved_in metal ion transport  
    involved_in monoatomic cation transmembrane transport  
    involved_in positive regulation of ATP-dependent activity  
    involved_in positive regulation of P-type sodium:potassium-exchanging transporter activity  
    involved_in positive regulation of potassium ion import across plasma membrane  
    involved_in positive regulation of potassium ion import across plasma membrane  
    involved_in positive regulation of potassium ion transmembrane transporter activity  
    involved_in positive regulation of sodium ion export across plasma membrane  
    involved_in positive regulation of sodium ion export across plasma membrane  
    involved_in potassium ion import across plasma membrane  
    involved_in potassium ion import across plasma membrane PubMed 
    involved_in potassium ion import across plasma membrane  
    involved_in potassium ion transport  
    involved_in protein localization to plasma membrane  
    involved_in protein localization to plasma membrane  
    involved_in protein stabilization PubMed 
    involved_in protein stabilization  
    involved_in proton transmembrane transport PubMed 
    involved_in regulation of calcium ion transmembrane transport PubMed 
    involved_in regulation of cardiac muscle contraction by calcium ion signaling PubMed 
    involved_in regulation of gene expression PubMed 
    involved_in relaxation of cardiac muscle PubMed 
    involved_in response to hypoxia  
    involved_in sodium ion export across plasma membrane  
    involved_in sodium ion export across plasma membrane PubMed 
    involved_in sodium ion export across plasma membrane  
    involved_in sodium ion transmembrane transport  
    involved_in sodium ion transport  
    Items 1 - 25 of 41
    Items 1 - 20 of 22
    Component Evidence Code Pubs
    located_in T-tubule  
    located_in T-tubule  
    located_in apical plasma membrane PubMed 
    located_in apical plasma membrane  
    located_in basolateral plasma membrane PubMed 
    located_in basolateral plasma membrane  
    located_in caveola  
    located_in intercalated disc PubMed 
    located_in lateral plasma membrane  
    located_in lateral plasma membrane  
    located_in membrane  
    located_in myelin sheath PubMed 
    located_in organelle membrane  
    located_in organelle membrane  
    located_in plasma membrane PubMed 
    located_in plasma membrane  
    located_in sarcolemma PubMed 
    part_of sodium:potassium-exchanging ATPase complex  
    part_of sodium:potassium-exchanging ATPase complex PubMed 
    part_of sodium:potassium-exchanging ATPase complex  
    located_in sperm flagellum  
    located_in sperm flagellum  
    Items 1 - 20 of 22

    General protein information

    Preferred Names
    sodium/potassium-transporting ATPase subunit beta-1
    Names
    sodium/potassium ATPase beta subunit
    sodium/potassium-dependent ATPase subunit beta-1
    NP_033851.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009721.6NP_033851.1  sodium/potassium-transporting ATPase subunit beta-1

      See identical proteins and their annotated locations for NP_033851.1

      Status: REVIEWED

      Source sequence(s)
      AK005071, AK010677, AK160405
      Consensus CDS
      CCDS35755.1
      UniProtKB/Swiss-Prot
      P14094
      UniProtKB/TrEMBL
      Q3TSQ1, Q3TV47, Q545P0
      Related
      ENSMUSP00000027863.8, ENSMUST00000027863.13
      Conserved Domains (1) summary
      TIGR01107
      Location:1304
      Na_K_ATPase_bet; Sodium Potassium ATPase beta subunit

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      164264668..164285924 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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