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    Tfam transcription factor A, mitochondrial [ Mus musculus (house mouse) ]

    Gene ID: 21780, updated on 27-Dec-2024

    Summary

    Official Symbol
    Tfamprovided by MGI
    Official Full Name
    transcription factor A, mitochondrialprovided by MGI
    Primary source
    MGI:MGI:107810
    See related
    Ensembl:ENSMUSG00000003923 AllianceGenome:MGI:107810
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hmgts; mtTFA; tsHMG
    Summary
    Enables mitochondrial promoter sequence-specific DNA binding activity. Involved in mitochondrial transcription. Acts upstream of or within mitochondrial respiratory chain complex assembly. Located in mitochondrial nucleoid. Is active in mitochondrion. Is expressed in several structures, including brain; branchial arch; genitourinary system; hemolymphoid system; and limb. Used to study Kearns-Sayre syndrome and Parkinson's disease. Human ortholog(s) of this gene implicated in Alzheimer's disease; Huntington's disease; Parkinson's disease; amyotrophic lateral sclerosis; and mitochondrial DNA depletion syndrome 15. Orthologous to human TFAM (transcription factor A, mitochondrial). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 10.2), liver E14 (RPKM 8.6) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Tfam in Genome Data Viewer
    Location:
    10 B5.3; 10 36.83 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (71061298..71074157, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (71225468..71238328, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA C730027H18 gene Neighboring gene predicted gene, 34328 Neighboring gene RIKEN cDNA 1700113B09 gene Neighboring gene STARR-positive B cell enhancer ABC_E2942 Neighboring gene STARR-positive B cell enhancer ABC_E6872 Neighboring gene ubiquitin-conjugating enzyme E2D 1 Neighboring gene predicted gene, 34376

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (4)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding, bending  
    enables chromatin binding  
    enables chromatin binding  
    enables heat shock protein binding  
    enables heat shock protein binding  
    enables mitochondrial promoter sequence-specific DNA binding PubMed 
    enables mitochondrial promoter sequence-specific DNA binding  
    enables mitochondrial promoter sequence-specific DNA binding  
    enables mitochondrial transcription factor activity  
    enables sequence-specific DNA binding  
    enables transcription cis-regulatory region binding  
    enables transcription coactivator binding  
    enables transcription coactivator binding  
    Component Evidence Code Pubs
    located_in mitochondrial matrix  
    located_in mitochondrial nucleoid PubMed 
    located_in mitochondrial nucleoid  
    located_in mitochondrial nucleoid  
    located_in mitochondrion PubMed 
    is_active_in mitochondrion PubMed 
    located_in mitochondrion PubMed 
    located_in mitochondrion  
    located_in nucleus  
    part_of protein-containing complex  
    part_of protein-containing complex  

    General protein information

    Preferred Names
    transcription factor A, mitochondrial
    Names
    TS-HMG
    testis-specific HMG-box protein m-tsHMG
    testis-specific high mobility group protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009360.4NP_033386.1  transcription factor A, mitochondrial precursor

      See identical proteins and their annotated locations for NP_033386.1

      Status: PROVISIONAL

      Source sequence(s)
      AC079680, AC153509
      Consensus CDS
      CCDS23916.1
      UniProtKB/Swiss-Prot
      P40630, P97894, P97906, Q543I8, Q9DBM9
      UniProtKB/TrEMBL
      Q3TSW9
      Related
      ENSMUSP00000090086.5, ENSMUST00000092430.11
      Conserved Domains (2) summary
      cd01390
      Location:154215
      HMGB-UBF_HMG-box; HMGB-UBF_HMG-box, class II and III members of the HMG-box superfamily of DNA-binding proteins. These proteins bind the minor groove of DNA in a non-sequence specific fashion and contain two or more tandem HMG boxes. Class II members include non-histone ...
      pfam00505
      Location:49116
      HMG_box; HMG (high mobility group) box

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      71061298..71074157 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017313918.3XP_017169407.1  transcription factor A, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A0R4J1N9
      Related
      ENSMUSP00000101072.4, ENSMUST00000105432.10
      Conserved Domains (2) summary
      cd01390
      Location:139200
      HMGB-UBF_HMG-box; class II and III members of the HMG-box superfamily of DNA-binding proteins. These proteins bind the minor groove of DNA in a non-sequence specific fashion and contain two or more tandem HMG boxes. Class II members include non-histone chromosomal ...
      pfam00505
      Location:34101
      HMG_box; HMG (high mobility group) box
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