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    ZNF776 zinc finger protein 776 [ Homo sapiens (human) ]

    Gene ID: 284309, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ZNF776provided by HGNC
    Official Full Name
    zinc finger protein 776provided by HGNC
    Primary source
    HGNC:HGNC:26765
    See related
    Ensembl:ENSG00000152443 AllianceGenome:HGNC:26765
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in bone marrow (RPKM 5.3), lymph node (RPKM 4.3) and 25 other tissues See more
    Orthologs
    all
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    Genomic context

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    See ZNF776 in Genome Data Viewer
    Location:
    19q13.43
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (57746815..57758148)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (60843753..60855084)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (58258183..58269516)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904783 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:58238691-58239191 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:58239145-58239370 Neighboring gene zinc finger protein 671 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15157 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:58280768-58281307 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15159 Neighboring gene zinc finger protein 586 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:58297126-58297745 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:58297746-58298364 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:58300764-58300910 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:58309809-58310356 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15160 Neighboring gene Sharpr-MPRA regulatory region 649 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:58314953-58315566 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:58322897-58323548 Neighboring gene zinc finger protein 552

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Integrated genome-wide association, coexpression network, and expression single nucleotide polymorphism analysis identifies novel pathway in allergic rhinitis. Bunyavanich S, et al. BMC Med Genomics, 2014 Aug 2. PMID 25085501, Free PMC Article
    2. Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells. Chang YJ, et al. Int J Mol Sci, 2023 Jun 6. PMID 37372979, Free PMC Article
    3. Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer. Yeow ZY, et al. Nature, 2020 Sep. PMID 32908313, Free PMC Article
    4. The in vivo Interaction Landscape of Histones H3.1 and H3.3. Siddaway R, et al. Mol Cell Proteomics, 2022 Oct. PMID 36089195, Free PMC Article
    5. Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy. Xiao T, et al. Proc Natl Acad Sci U S A, 2018 Jul 31. PMID 29987050, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
    2. Observational study of gene-disease association. (HuGE Navigator)
      Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Integrated Genome-wide Association, Coexpression Network, and Expression Single Nucleotide Polymorphism Analysis Identifies Novel Pathway in Allergic Rhinitis.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ30886, FLJ38288, DKFZp781G1213, DKFZp686K10134

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 776

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_052796.1 RefSeqGene

      Range
      5020..16353
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001348007.2 → NP_001334936.1  zinc finger protein 776 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice structure in its 3' coding region, resulting in a translational frameshift and shorter 3' UTR, compared to variant 1. The encoded isoform (2) is substantially shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK127764, AK299680, BX105932, DA534001
      UniProtKB/Swiss-Prot
      Q68DI1
      UniProtKB/TrEMBL
      B4DSC6
      Conserved Domains (1) summary
      pfam01352
      Location:13 → 54
      KRAB; KRAB box

    2. NM_173632.4 → NP_775903.3  zinc finger protein 776 isoform 1

      See identical proteins and their annotated locations for NP_775903.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AI446541, AK127764, AK299680, BC136753, CR936802
      Consensus CDS
      CCDS12962.2
      UniProtKB/Swiss-Prot
      Q68DI1, Q6ZS36, Q8N968
      Related
      ENSP00000321812.5, ENST00000317178.10
      Conserved Domains (5) summary
      smart00349
      Location:14 → 55
      KRAB; krueppel associated box
      COG5048
      Location:291 → 439
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:322 → 342
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:14 → 53
      KRAB; KRAB box
      pfam13465
      Location:390 → 415
      zf-H2C2_2; Zinc-finger double domain

    RNA

    1. NR_145326.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate exon structure near its 3' end compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK127764, AK299680, BX105932, DA534001

    2. NR_145327.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains an alternate exon structure near its 3' end compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK127764, AK299680, BX105932, CR936802, DA534001

    3. NR_145328.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks an alternate internal exon to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
      Source sequence(s)
      AK127764, BX105932, HY045891

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      57746815..57758148
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      60843753..60855084
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q68DI1.2 GenPept UniProtKB/Swiss-Prot:Q68DI1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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