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    bur burgundy [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 45830, updated on 9-Dec-2024

    Summary

    Official Symbol
    burprovided by FlyBase
    Official Full Name
    burgundyprovided by FlyBase
    Primary source
    FLYBASE:FBgn0000239
    Locus tag
    Dmel_CG9242
    See related
    AllianceGenome:FB:FBgn0000239
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.193; anon-WO0118547.204; Bur; CG9242; Dmel\CG9242; ES2-2; Gmps; GMPS; gua2; l(2)10523; P174
    Summary
    Enables deubiquitinase activator activity. Involved in axon guidance; positive regulation of heterochromatin formation; and positive regulation of smoothened signaling pathway. Located in polytene chromosome. Part of protein-containing complex. Is expressed in adult head. Human ortholog(s) of this gene implicated in acute myelomonocytic leukemia. Orthologous to human GMPS (guanine monophosphate synthase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See bur in Genome Data Viewer
    Location:
    39A7-39B1; 2-54 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (21174182..21179683, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (21174182..21179683, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Mitochondrial aconitase 1 Neighboring gene small Cajal body-specific RNA : PsiU2-38.40.42 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44911 Neighboring gene Minichromosome maintenance 10 Neighboring gene Ret oncogene Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding  
    enables GMP synthase (glutamine-hydrolyzing) activity  
    enables GMP synthase (glutamine-hydrolyzing) activity  
    enables GMP synthase activity  
    enables GMP synthase activity  
    enables deubiquitinase activator activity PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol  
    located_in polytene chromosome PubMed 
    part_of protein-containing complex PubMed 

    General protein information

    Preferred Names
    burgundy
    Names
    CG9242-PB
    CG9242-PC
    GMP synthetase
    GMP-synthetase
    bur-PB
    bur-PC
    enhancer of GMR-sina 2-2
    NP_001286120.1
    NP_620114.3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      21174182..21179683 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299191.1 → NP_001286120.1  burgundy, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286120.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MSU9, Q8WSN4, Q9VIE7
      Conserved Domains (3) summary
      cd01742
      Location:19 → 199
      GATase1_GMP_Synthase; Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase
      PRK00074
      Location:16 → 683
      guaA; GMP synthase; Reviewed
      cd01997
      Location:230 → 682
      GMP_synthase_C; The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched ...
    2. NM_138759.4 → NP_620114.3  burgundy, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_620114.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MSU9, Q8WSN4, Q9VIE7
      Conserved Domains (3) summary
      cd01742
      Location:19 → 199
      GATase1_GMP_Synthase; Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase
      PRK00074
      Location:16 → 683
      guaA; GMP synthase; Reviewed
      cd01997
      Location:230 → 682
      GMP_synthase_C; The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched ...
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