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    Ir40a Ionotropic receptor 40a [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35449, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ir40aprovided by FlyBase
    Official Full Name
    Ionotropic receptor 40aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0259683
    Locus tag
    Dmel_CG42352
    See related
    AllianceGenome:FB:FBgn0259683
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    40a; CG42352; CG5922; CG5929; DmelIR40a; Dmel\CG42352; Ir40A; IR40a
    Old locus tag
    Dmel_CG5922; Dmel_CG5929
    Summary
    Predicted to enable ligand-gated monoatomic ion channel activity. Involved in detection of chemical stimulus involved in sensory perception. Predicted to be located in membrane. Is expressed in adult hygrosensory neuron Ir40a; antennal lobe glomerulus VP; and antennal segment 3 sense organ. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ir40a in Genome Data Viewer
    Location:
    40F3-40F4; 2-54 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (22189526..22214376, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (22189526..22214376, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44809 Neighboring gene uncharacterized protein Neighboring gene Microsomal glutathione S-transferase-like pseudogene Neighboring gene long non-coding RNA:CR43765

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ir40a neurons are not DEET detectors. Silbering AF, et al. Nature, 2016 Jun 23. PMID 27337300
    2. Ionotropic Receptor-dependent moist and dry cells control hygrosensation in Drosophila. Knecht ZA, et al. Elife, 2017 Jun 16. PMID 28621663, Free PMC Article
    3. Early Integration of Temperature and Humidity Stimuli in the Drosophila Brain. Frank DD, et al. Curr Biol, 2017 Aug 7. PMID 28736172, Free PMC Article
    4. Humidity response depends on the small soluble protein Obp59a in Drosophila. Sun JS, et al. Elife, 2018 Sep 19. PMID 30230472, Free PMC Article
    5. Humidity Sensing in Drosophila. Enjin A, et al. Curr Biol, 2016 May 23. PMID 27161501, Free PMC Article

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    mobile_element

    • Loc: c22192732-22192652 mobile_element_type = transposon:gypsy8{}2095
    • Loc: c22193315-22192908 mobile_element_type = transposon:INE-1{}6140
    • Loc: c22193889-22193767 mobile_element_type = transposon:diver2{}2070
    • Loc: c22196064-22195667 mobile_element_type = transposon:INE-1{}6141
    • Loc: c22200623-22199990 mobile_element_type = transposon:FB{}538
    • Loc: c22206551-22201408 mobile_element_type = transposon:copia{}539
    • Loc: c22207089-22201105 mobile_element_type = transposon:Cr1a{}1995
    • Loc: c22209490-22200858 mobile_element_type = transposon:Cr1a{}2297
    • Loc: c22209920-22209491 mobile_element_type = transposon:INE-1{}6151

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ligand-gated monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligand-gated monoatomic ion channel activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in detection of chemical stimulus involved in sensory perception IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ionotropic receptor 40a
    Names
    CG42352-PE
    CG42352-PF
    CG42352-PG
    Ir40a-PE
    Ir40a-PF
    Ir40a-PG

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      22189526..22214376 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136296.4 → NP_610140.4  ionotropic receptor 40a, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610140.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B3DNK0, Q9V9N1
      Conserved Domains (2) summary
      cl21456
      Location:496 → 637
      Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
      cl25412
      Location:216 → 338
      PBP2_LTTR_substrate; The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily

    2. NM_001299203.1 → NP_001286132.1  ionotropic receptor 40a, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286132.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JAN0
      Conserved Domains (1) summary
      cl21456
      Location:12 → 128
      Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily

    3. NM_001273758.2 → NP_001260687.1  ionotropic receptor 40a, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260687.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PGG3
      Conserved Domains (1) summary
      cl21456
      Location:44 → 185
      Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PGG3 M9PGG3
    Q9V9N1.4 Q9V9N1
    X2JAN0 X2JAN0

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