gogo golden goal [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: gogoprovided by FlyBase
Official Full Name: golden goalprovided by FlyBase
Primary source: FLYBASE:FBgn0052227
Locus tag: Dmel_CG32227
See related: AllianceGenome:FB:FBgn0052227
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG13815; CG13817; CG32227; CT33316; Dmel\CG32227; Gogo
Summary: Involved in photoreceptor cell axon guidance and retinal ganglion cell axon guidance. Located in growth cone and plasma membrane. Is expressed in several structures, including embryonic/larval optic lobe; eye disc posterior to the morphogenetic furrow; imaginal disc; photoreceptor neurons; and synaptic neuropil domain. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 77B1-77B1; 3-47 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (20268859..20295133, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (20261959..20288233, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Fmi and Gogo function downstream of Otd in retina.
Title: Orthodenticle Is Required for the Expression of Principal Recognition Molecules That Control Axon Targeting in the Drosophila Retina.
The cytoplasmic part of Gogo is required for its function in dendritic tree formation, suggesting that Gogo conveys information from extracellular cues to intracellular molecules that control dendrite development.
Title: Golden goal controls dendrite elongation and branching of multidendritic arborization neurons in Drosophila.
Gogo contributes to retinotopic map formation in the Drosophila lamina by controlling the distribution of R1-R6 axon fascicles.
Title: Gogo receptor contributes to retinotopic map formation and prevents R1-6 photoreceptor axon bundling.
Data show that a conserved Tyr-Tyr-Asp (YYD) tripeptide motif in the Gogo cytoplasmic domain is required for photoreceptor axon targeting.
Title: A putative tyrosine phosphorylation site of the cell surface receptor Golden goal is involved in synaptic layer selection in the visual system.
Gogo both positively and negatively regulates Hts that affects the Actin-Spectrin cytoskeleton in growth cone filopodia, thereby guiding photoreceptor axons.
Title: Hts, the Drosophila homologue of Adducin, physically interacts with the transmembrane receptor Golden goal to guide photoreceptor axons.
Data suggest that Gogo acts as a functional partner of Fmi for R8 photoreceptor axon targeting and that the dynamic regulation of their interaction specifies synaptic-layer selection of photoreceptors.
Title: Golden Goal collaborates with Flamingo in conferring synaptic-layer specificity in the visual system.
Golden Goal (Gogo) regulates axon-axon interactions and axon-target interactions in R8 photoreceptor axons.
Title: The transmembrane protein Golden goal regulates R8 photoreceptor axon-axon and axon-target interactions.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: c20283942-20283884 mobile_element_type = transposon:INE-1{}5300

Gene Ontology Provided by FlyBase

Process	Evidence Code	Pubs
involved_in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in photoreceptor cell axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in retinal ganglion cell axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
is_active_in cell periphery	IBA Inferred from Biological aspect of Ancestor more info
located_in growth cone	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISM Inferred from Sequence Model more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: golden goal

Names: CG32227-PA; gogo-PA

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

20268859..20295133 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_140943.3 → NP_649200.2 golden goal [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_649200.2

Status: REVIEWED

UniProtKB/TrEMBL

Q7YU55, Q9VWA7

Related

FBpp0074617

Conserved Domains (3) summary

smart00209
Location:459 → 505

TSP1; Thrombospondin type 1 repeats

pfam15304
Location:1049 → 1146

AKAP2_C; A-kinase anchor protein 2 C-terminus

cl00049
Location:570 → 640

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.