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    Y37E3.17 Dimethylglycine dehydrogenase, mitochondrial [ Caenorhabditis elegans ]

    Gene ID: 171775, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Y37E3.17
    Official Full Name
    Dimethylglycine dehydrogenase, mitochondrial
    Primary source
    WormBase:WBGene00021355
    Locus tag
    CELE_Y37E3.17
    See related
    AllianceGenome:WB:WBGene00021355
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable dimethylglycine dehydrogenase activity. Predicted to be active in mitochondrial matrix. Used to study dimethylglycine dehydrogenase deficiency. Human ortholog(s) of this gene implicated in dimethylglycine dehydrogenase deficiency. Orthologous to human DMGDH (dimethylglycine dehydrogenase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See Y37E3.17 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    11
    Sequence:
    Chromosome: I; NC_003279.8 (2128588..2145971)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Nuclear pore protein Neighboring gene Uncharacterized protein Neighboring gene Solute carrier family 40 member Neighboring gene Rx N-terminal domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cell size and fat content of dietary-restricted Caenorhabditis elegans are regulated by ATX-2, an mTOR repressor. Bar DZ, et al. Proc Natl Acad Sci U S A, 2016 Aug 9. PMID 27457958, Free PMC Article
    2. The Caenorhabditis elegans RDE-10/RDE-11 complex regulates RNAi by promoting secondary siRNA amplification. Zhang C, et al. Curr Biol, 2012 May 22. PMID 22542102, Free PMC Article
    3. CCAR-1 works together with the U2AF large subunit UAF-1 to regulate alternative splicing. Lugano DI, et al. RNA Biol, 2024 Jan. PMID 38126797, Free PMC Article
    4. SIN-3 acts in distinct complexes to regulate the germline transcriptional program in Caenorhabditis elegans. Robert VJ, et al. Development, 2023 Nov 1. PMID 37818613, Free PMC Article
    5. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables dimethylglycine dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Dimethylglycine dehydrogenase, mitochondrial
    NP_001021745.1
    • Confirmed by transcript evidence
    NP_001021746.1
    • Confirmed by transcript evidence
    NP_001360455.1
    • Confirmed by transcript evidence
    NP_001360456.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      2128588..2145971
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001373685.2 → NP_001360455.1  Dimethylglycine dehydrogenase, mitochondrial [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A486WV52
      Conserved Domains (2) summary
      COG0404
      Location:440 → 831
      GcvT; Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]
      COG0665
      Location:26 → 414
      DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]

    2. NM_001026574.4 → NP_001021745.1  Dimethylglycine dehydrogenase, mitochondrial [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021745.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2L0N9
      Conserved Domains (6) summary
      COG0404
      Location:440 → 828
      GcvT; Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]
      pfam01266
      Location:31 → 392
      DAO; FAD dependent oxidoreductase
      pfam01571
      Location:451 → 714
      GCV_T; Aminomethyltransferase folate-binding domain
      pfam08669
      Location:722 → 819
      GCV_T_C; Glycine cleavage T-protein C-terminal barrel domain
      pfam13450
      Location:32 → 88
      NAD_binding_8; NAD(P)-binding Rossmann-like domain
      pfam16350
      Location:395 → 446
      FAO_M; FAD dependent oxidoreductase central domain

    3. NM_001026575.7 → NP_001021746.1  Dimethylglycine dehydrogenase, mitochondrial [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021746.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6AW03
      Conserved Domains (6) summary
      COG0404
      Location:447 → 835
      GcvT; Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]
      COG0665
      Location:26 → 421
      DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]
      pfam01571
      Location:458 → 721
      GCV_T; Aminomethyltransferase folate-binding domain
      pfam08669
      Location:729 → 826
      GCV_T_C; Glycine cleavage T-protein C-terminal barrel domain
      pfam13450
      Location:32 → 95
      NAD_binding_8; NAD(P)-binding Rossmann-like domain
      pfam16350
      Location:402 → 453
      FAO_M; FAD dependent oxidoreductase central domain

    4. NM_001373684.2 → NP_001360456.1  Dimethylglycine dehydrogenase, mitochondrial [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A486WWC6
      Conserved Domains (2) summary
      COG0404
      Location:447 → 838
      GcvT; Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]
      COG0665
      Location:26 → 421
      DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version

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