zip zipper [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: zipprovided by FlyBase
Official Full Name: zipperprovided by FlyBase
Primary source: FLYBASE:FBgn0287873
Locus tag: Dmel_CG15792
See related: AllianceGenome:FB:FBgn0287873
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: actomyosin; anon-WO0140519.37; cbe; CG15792; Dm nmII; Dmel\CG15792; DmnmII; DROMHC; Dronm-MII; E(br); l(2)02957; l(2)17F1; MHC; Mhc-c; Mhc-c[1]; Myo; myo II; Myo II; Myo-II; Myo-II HC; Myo15; Myo2; myoII; MyoII; myosin II; Myosin II; myosin-II; Myosin-II; NMII; NMM; nmMHC; NMMII; nmy-2; Zip; ZIP; zip/MyoII; zpr
Summary: Enables myosin light chain binding activity. Involved in several processes, including embryonic development via the syncytial blastoderm; open tracheal system development; and regionalization. Located in several cellular components, including Z disc; apicomedial cortex; and basal cortex. Part of myosin II complex. Colocalizes with apical cortex. Is expressed in several structures, including adult brain cell body rind; adult head; brain; epithelium; and gut section. Used to study MYH-9 related disease. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 60E11-60E12; 2-107 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (24990570..25011965, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (20878093..20899488, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Regulation of Notch signaling by non-muscle myosin II Zipper in Drosophila.
Title: Regulation of Notch signaling by non-muscle myosin II Zipper in Drosophila.
From network analysis to experimental validation: identification of regulators of non-muscle myosin II contractility using the folded-gastrulation signaling pathway.
Title: From network analysis to experimental validation: identification of regulators of non-muscle myosin II contractility using the folded-gastrulation signaling pathway.
Elimination of aberrantly specified cell clones is independent of interfacial Myosin II accumulation.
Title: Elimination of aberrantly specified cell clones is independent of interfacial Myosin II accumulation.
Competition between myosin II and betaH-spectrin regulates cytoskeletal tension.
Title: Competition between myosin II and β(H)-spectrin regulates cytoskeletal tension.
A novel coordinated function of Myosin II with GOLPH3 controls centralspindlin localization during cytokinesis in Drosophila.
Title: A novel coordinated function of Myosin II with GOLPH3 controls centralspindlin localization during cytokinesis in Drosophila.
Disease-associated mutations in the myosin II motor domain disrupt specific aspects of myosin function and cause defects in tissue morphogenesis.
Title: Cellular defects resulting from disease-related myosin II mutations in Drosophila.
study highlights the activity and distribution controls of basal myosin contractility mediated by cell-matrix and cell-cell adhesions, respectively, during tissue morphogenesis
Title: Cell-matrix adhesion and cell-cell adhesion differentially control basal myosin oscillation and Drosophila egg chamber elongation.
This study demonstrated that endogenous mechanical cues trigger biochemical pathways, generating the active morphogenetic movements shaping animal development through a mechanotransductive cascade of Myo-II medio-apical stabilization.
Title: Mechanotransductive cascade of Myo-II-dependent mesoderm and endoderm invaginations in embryo gastrulation.
Analyzing the dynamics of junction shortening and elongation resulting from myosin II pulses, the authors find that long pulses yield less reversible deformations, typically a signature of dissipative mechanics. This is consistent with a simple viscoelastic description, which we use to model individual shortening and elongation events.
Title: Viscoelastic Dissipation Stabilizes Cell Shape Changes during Tissue Morphogenesis.
A dual role of myosin II in regulating the development of the Drosophila wing, is reported.
Title: Dual role of myosin II during Drosophila imaginal disc metamorphosis.

Submit: New GeneRIF Correction See all GeneRIFs (26)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	IEA Inferred from Electronic Annotation more info
enables cytoskeletal motor activity	IEA Inferred from Electronic Annotation more info
enables microfilament motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables microfilament motor activity	ISS Inferred from Sequence or Structural Similarity more info
enables myosin light chain binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Malpighian tubule morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in anterior midgut development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in border follicle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to mechanical stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in compartment boundary maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cuticle pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cytoskeleton-dependent cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal closure	IGI Inferred from Genetic Interaction more info	PubMed
involved_in dorsal closure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal closure, amnioserosa morphology change	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal closure, leading edge cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal closure, spreading of leading edge cells	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in eye-antennal disc morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in head involution	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing hair organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in left/right axis specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in maintenance of protein location in cell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in morphogenesis of an epithelial fold	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in muscle attachment	IGI Inferred from Genetic Interaction more info	PubMed
involved_in muscle contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in myofibril assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in myosin II filament assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of border follicle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of establishment of planar polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of myoblast fusion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of tube length, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in salivary gland morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sarcomere organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory perception of sound	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spiracle morphogenesis, open tracheal system	IDA Inferred from Direct Assay more info	PubMed
involved_in wound healing	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Z disc	IDA Inferred from Direct Assay more info	PubMed
located_in actomyosin contractile ring	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with apical cortex	IDA Inferred from Direct Assay more info	PubMed
located_in apicomedial cortex	IDA Inferred from Direct Assay more info	PubMed
located_in basal cortex	IDA Inferred from Direct Assay more info	PubMed
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
located_in cell cortex	IMP Inferred from Mutant Phenotype more info	PubMed
located_in cell leading edge	IDA Inferred from Direct Assay more info	PubMed
located_in cell-cell contact zone	IDA Inferred from Direct Assay more info	PubMed
located_in cleavage furrow	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with contractile ring	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	HDA more info	PubMed
part_of myosin II complex	IBA Inferred from Biological aspect of Ancestor more info
part_of myosin II complex	IDA Inferred from Direct Assay more info	PubMed
part_of myosin II complex	IPI Inferred from Physical Interaction more info	PubMed
part_of myosin complex	IEA Inferred from Electronic Annotation more info
is_active_in myosin filament	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: zipper

Names: CG15792-PA; CG15792-PB; CG15792-PC; CG15792-PD; CG15792-PE; CG15792-PF; CG15792-PG; CG15792-PH; CG15792-PI; MyoII heavy chain; Myosin-2; Myosin-II; actomyosin; celibe; cytoplasmic myosin; cytoplasmic myosin II; cytoplasmic myosin heavy chain; cytoplasmic myosin-II; enhancer of broad; lethal (2) 17F1; myo-II heavy chain; myosin; myosin 2; myosin HC; myosin II; myosin II heavy chain; myosin heavy chain; myosin heavy chain-cytoplasmic; myosin-heavy-chain-cytoplasmic; myosins II; non muscle myosin; non-muscle myosin; non-muscle myosin II; non-muscle myosin II heavy chain; non-muscle myosin heavy-chain; non-muscle myosin-II; nonmuscle MyoII; nonmuscle myosin II; nonmuscle myosin II heavy chain; nonmuscle myosin II heavychain; nonmuscle myosin heavy chain; nonmuscle myosin-II; nonmuscle myosin-II heavy chain; zip-PA; zip-PB; zip-PC; zip-PD; zip-PE; zip-PF; zip-PG; zip-PH; zip-PI; zipper heavy chain

NP_001014552.1

EC 5.6.1.8

NP_001014553.1

EC 5.6.1.8

NP_001189008.1

EC 5.6.1.8

NP_001189009.1

EC 5.6.1.8

NP_001189010.1

EC 5.6.1.8

NP_001189011.1

EC 5.6.1.8

NP_001246516.1

EC 5.6.1.8

NP_523860.2

EC 5.6.1.8

NP_726506.1

EC 5.6.1.8

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

24990570..25011965 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_166704.4 → NP_726506.1 zipper, isoform B [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q24138, Q7JPC1, Q7JPC2, Q8MMC2, Q94987, Q94992, Q99323, Q9W0W8

Related

FBpp0072305

Conserved Domains (6) summary

cd14911
Location:100 → 809

MYSc_Myh2_insects_mollusks; class II myosin heavy chain 2, motor domain

pfam00063
Location:88 → 809

Myosin_head; Myosin head (motor domain)

pfam01576
Location:886 → 1966

Myosin_tail_1; Myosin tail

pfam02736
Location:35 → 72

Myosin_N; Myosin N-terminal SH3-like domain

pfam16046
Location:1802 → 1881

FAM76; FAM76 protein

cl09111
Location:1386 → 1470

Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
NM_001202079.1 → NP_001189008.1 zipper, isoform E [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q24138, Q7JPC1, Q7JPC2, Q8MMC2, Q94987, Q94992, Q99323, Q9W0W8

UniProtKB/TrEMBL

Q59E58

Conserved Domains (6) summary

cd14911
Location:100 → 769

MYSc_Myh2_insects_mollusks; class II myosin heavy chain 2, motor domain

pfam00063
Location:88 → 769

Myosin_head; Myosin head (motor domain)

pfam01576
Location:846 → 1926

Myosin_tail_1; Myosin tail

pfam02736
Location:35 → 72

Myosin_N; Myosin N-terminal SH3-like domain

pfam16046
Location:1762 → 1841

FAM76; FAM76 protein

cl09111
Location:1346 → 1430

Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
NM_001014553.3 → NP_001014553.1 zipper, isoform C [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q24138, Q7JPC1, Q7JPC2, Q8MMC2, Q94987, Q94992, Q99323, Q9W0W8

UniProtKB/TrEMBL

Q59E58

Conserved Domains (6) summary

cd14911
Location:100 → 769

MYSc_Myh2_insects_mollusks; class II myosin heavy chain 2, motor domain

pfam00063
Location:88 → 769

Myosin_head; Myosin head (motor domain)

pfam01576
Location:846 → 1926

Myosin_tail_1; Myosin tail

pfam02736
Location:35 → 72

Myosin_N; Myosin N-terminal SH3-like domain

pfam16046
Location:1762 → 1841

FAM76; FAM76 protein

cl09111
Location:1346 → 1430

Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
NM_001202080.2 → NP_001189009.1 zipper, isoform F [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q24138, Q7JPC1, Q7JPC2, Q8MMC2, Q94987, Q94992, Q99323, Q9W0W8

UniProtKB/TrEMBL

A0A0B4JD57

Conserved Domains (6) summary

cd14911
Location:100 → 777

MYSc_Myh2_insects_mollusks; class II myosin heavy chain 2, motor domain

pfam00063
Location:88 → 777

Myosin_head; Myosin head (motor domain)

pfam01576
Location:854 → 1934

Myosin_tail_1; Myosin tail

pfam02736
Location:35 → 72

Myosin_N; Myosin N-terminal SH3-like domain

pfam16046
Location:1770 → 1849

FAM76; FAM76 protein

cl09111
Location:1354 → 1438

Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
NM_001202082.2 → NP_001189011.1 zipper, isoform H [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q24138, Q7JPC1, Q7JPC2, Q8MMC2, Q94987, Q94992, Q99323, Q9W0W8

UniProtKB/TrEMBL

A0A0B4JD95

Conserved Domains (6) summary

cd14911
Location:100 → 777

MYSc_Myh2_insects_mollusks; class II myosin heavy chain 2, motor domain

pfam00063
Location:88 → 777

Myosin_head; Myosin head (motor domain)

pfam01576
Location:854 → 1934

Myosin_tail_1; Myosin tail

pfam02736
Location:35 → 72

Myosin_N; Myosin N-terminal SH3-like domain

pfam16046
Location:1770 → 1849

FAM76; FAM76 protein

cl09111
Location:1354 → 1438

Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
NM_001014552.3 → NP_001014552.1 zipper, isoform D [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q24138, Q7JPC1, Q7JPC2, Q8MMC2, Q94987, Q94992, Q99323, Q9W0W8

UniProtKB/TrEMBL

Q59E59

Conserved Domains (6) summary

cd14911
Location:145 → 814

MYSc_Myh2_insects_mollusks; class II myosin heavy chain 2, motor domain

pfam00063
Location:133 → 814

Myosin_head; Myosin head (motor domain)

pfam01576
Location:891 → 1971

Myosin_tail_1; Myosin tail

pfam02736
Location:80 → 117

Myosin_N; Myosin N-terminal SH3-like domain

pfam16046
Location:1807 → 1886

FAM76; FAM76 protein

cl09111
Location:1391 → 1475

Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
NM_079136.4 → NP_523860.2 zipper, isoform A [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q24138, Q7JPC1, Q7JPC2, Q8MMC2, Q94987, Q94992, Q99323, Q9W0W8

Related

FBpp0072306

Conserved Domains (6) summary

cd14911
Location:145 → 854

MYSc_Myh2_insects_mollusks; class II myosin heavy chain 2, motor domain

pfam00063
Location:133 → 854

Myosin_head; Myosin head (motor domain)

pfam01576
Location:931 → 2011

Myosin_tail_1; Myosin tail

pfam02736
Location:80 → 117

Myosin_N; Myosin N-terminal SH3-like domain

pfam16046
Location:1847 → 1926

FAM76; FAM76 protein

cl09111
Location:1431 → 1515

Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
NM_001259587.2 → NP_001246516.1 zipper, isoform I [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q24138, Q7JPC1, Q7JPC2, Q8MMC2, Q94987, Q94992, Q99323, Q9W0W8

UniProtKB/TrEMBL

A0A0B4K7Q4

Conserved Domains (6) summary

cd14911
Location:145 → 822

MYSc_Myh2_insects_mollusks; class II myosin heavy chain 2, motor domain

pfam00063
Location:133 → 822

Myosin_head; Myosin head (motor domain)

pfam01576
Location:899 → 1979

Myosin_tail_1; Myosin tail

pfam02736
Location:80 → 117

Myosin_N; Myosin N-terminal SH3-like domain

pfam16046
Location:1815 → 1894

FAM76; FAM76 protein

cl09111
Location:1399 → 1483

Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
NM_001202081.1 → NP_001189010.1 zipper, isoform G [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q24138, Q7JPC1, Q7JPC2, Q8MMC2, Q94987, Q94992, Q99323, Q9W0W8

UniProtKB/TrEMBL

Q59E58

Conserved Domains (6) summary

cd14911
Location:100 → 769

MYSc_Myh2_insects_mollusks; class II myosin heavy chain 2, motor domain

pfam00063
Location:88 → 769

Myosin_head; Myosin head (motor domain)

pfam01576
Location:846 → 1926

Myosin_tail_1; Myosin tail

pfam02736
Location:35 → 72

Myosin_N; Myosin N-terminal SH3-like domain

pfam16046
Location:1762 → 1841

FAM76; FAM76 protein

cl09111
Location:1346 → 1430

Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...