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    EndoGI Endonuclease G inhibitor [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34953, updated on 9-Dec-2024

    Summary

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    Official Symbol
    EndoGIprovided by FlyBase
    Official Full Name
    Endonuclease G inhibitorprovided by FlyBase
    Primary source
    FLYBASE:FBgn0028515
    Locus tag
    Dmel_CG4930
    See related
    AllianceGenome:FB:FBgn0028515
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BG:DS07473.2; CG4930; dEndoGI; Dmel\CG4930; endoGI
    Summary
    Enables ribonuclease inhibitor activity. Involved in positive regulation of Notch signaling pathway. Located in nucleus. Is expressed in several structures, including adult head; cuboidal/columnar epithelium; embryonic/larval salivary gland; ganglia; and nurse cell. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See EndoGI in Genome Data Viewer
    Location:
    35F1-35F1; 2-52 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (16257688..16259511)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (16257688..16259511)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene PRL-1 phosphatase Neighboring gene twine Neighboring gene uncharacterized protein Neighboring gene cropped

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crystal structure of the EndoG/EndoGI complex: mechanism of EndoG inhibition. Loll B, et al. Nucleic Acids Res, 2009 Nov. PMID 19783821, Free PMC Article
    2. The Drosophila melanogaster Gene cg4930 Encodes a High Affinity Inhibitor for Endonuclease G. Temme C, et al. J Biol Chem, 2009 Mar 27. PMID 19129189, Free PMC Article
    3. Barriers to male transmission of mitochondrial DNA in sperm development. DeLuca SZ, et al. Dev Cell, 2012 Mar 13. PMID 22421049, Free PMC Article
    4. EndoGI modulates Notch signaling and axon guidance in Drosophila. O'Keefe DD, et al. Mech Dev, 2011 Jan-Feb. PMID 21055464, Free PMC Article
    5. Hotspots of transcription factor colocalization in the genome of Drosophila melanogaster. Moorman C, et al. Proc Natl Acad Sci U S A, 2006 Aug 8. PMID 16880385, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. EndoGI functioning as a positive regulator of the Notch signaling pathway, playing a critical role during axon guidance of motor neurons.
      Title: EndoGI modulates Notch signaling and axon guidance in Drosophila.
    2. The Drosophila melanogaster Gene cg4930 Encodes a High Affinity Inhibitor for Endonuclease G.
      Title: The Drosophila melanogaster Gene cg4930 Encodes a High Affinity Inhibitor for Endonuclease G.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ribonuclease inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of Notch signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    endonuclease G inhibitor
    Names
    CG4930-PA
    CG4930-PB
    CG4930-PC
    EndoGI-PA
    EndoGI-PB
    EndoGI-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      16257688..16259511
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273560.1 → NP_001260489.1  endonuclease G inhibitor, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260489.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V3V9
      Conserved Domains (1) summary
      pfam08785
      Location:31 → 138
      Ku_PK_bind; Ku C terminal domain like

    2. NM_001273561.2 → NP_001260490.1  endonuclease G inhibitor, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260490.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V3V9
      Conserved Domains (1) summary
      pfam08785
      Location:31 → 138
      Ku_PK_bind; Ku C terminal domain like

    3. NM_135937.3 → NP_609781.1  endonuclease G inhibitor, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609781.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V3V9
      Related
      FBpp0080382
      Conserved Domains (1) summary
      pfam08785
      Location:31 → 138
      Ku_PK_bind; Ku C terminal domain like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9V3V9 Q9V3V9

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