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    Rcd-1 Required for cell differentiation 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32966, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rcd-1provided by FlyBase
    Official Full Name
    Required for cell differentiation 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0031047
    Locus tag
    Dmel_CG14213
    See related
    AllianceGenome:FB:FBgn0031047
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Caf40; CAF40; CG14213; CNOT9; Dmel\CG14213; Drcd-1; Rcd1
    Summary
    Involved in mRNA catabolic process and negative regulation of translation. Part of CCR4-NOT complex. Is expressed in several structures, including adult central nervous system; adult digestive system; adult muscle system; adult mushroom body; and adult peripheral nervous system. Orthologous to human CNOT9 (CCR4-NOT transcription complex subunit 9). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Rcd-1 in Genome Data Viewer
    Location:
    18D11-18D11; 1-63 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (19638767..19640746)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (19532800..19534779)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene MAPK Phosphatase 4 Neighboring gene uncharacterized protein Neighboring gene enhancer of yellow 3 Neighboring gene uncharacterized protein Neighboring gene Sec61 gamma subunit

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Rapid Cis-Trans Coevolution Driven by a Novel Gene Retroposed from a Eukaryotic Conserved CCR4-NOT Component in Drosophila. Krinsky BH, et al. Genes (Basel), 2021 Dec 26. PMID 35052398, Free PMC Article
    2. Evolution of H3K27me3-marked chromatin is linked to gene expression evolution and to patterns of gene duplication and diversification. Arthur RK, et al. Genome Res, 2014 Jul. PMID 24985914, Free PMC Article
    3. Reshaping of global gene expression networks and sex-biased gene expression by integration of a young gene. Chen S, et al. EMBO J, 2012 Jun 13. PMID 22543869, Free PMC Article
    4. Rapid Gene Evolution in an Ancient Post-transcriptional and Translational Regulatory System Compensates for Meiotic X Chromosomal Inactivation. Xia S, et al. Mol Biol Evol, 2022 Jan 7. PMID 34626117, Free PMC Article
    5. Drosophila Bag-of-marbles directly interacts with the CAF40 subunit of the CCR4-NOT complex to elicit repression of mRNA targets. Sgromo A, et al. RNA, 2018 Mar. PMID 29255063, Free PMC Article

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Bam regulates the expression of its mRNA targets by recruiting the CCR4-NOT complex through interaction with CAF40.
      Title: Drosophila Bag-of-marbles directly interacts with the CAF40 subunit of the CCR4-NOT complex to elicit repression of mRNA targets.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mRNA catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of translation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of CCR4-NOT complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of CCR4-NOT complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of CCR4-NOT core complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in P-body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    required for cell differentiation 1
    Names
    CG14213-PA
    CG14213-PB
    CG14213-PC
    Rcd-1-PA
    Rcd-1-PB
    Rcd-1-PC
    required for cell differentiation 1 ortholog

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      19638767..19640746
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272793.2 → NP_001259722.1  required for cell differentiation 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259722.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PF85
      Conserved Domains (1) summary
      pfam04078
      Location:37 → 285
      Rcd1; Cell differentiation family, Rcd1-like

    2. NM_167675.2 → NP_728284.1  required for cell differentiation 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728284.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JVP2
      Related
      FBpp0074513
      Conserved Domains (1) summary
      pfam04078
      Location:40 → 288
      Rcd1; Cell differentiation family, Rcd1-like

    3. NM_134491.4 → NP_608335.1  required for cell differentiation 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608335.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JVP2
      Related
      FBpp0074512
      Conserved Domains (1) summary
      pfam04078
      Location:40 → 288
      Rcd1; Cell differentiation family, Rcd1-like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PF85 M9PF85
    Q7JVP2 Q7JVP2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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