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    mrj mrj [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36797, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mrjprovided by FlyBase
    Official Full Name
    mrjprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034091
    Locus tag
    Dmel_CG8448
    See related
    AllianceGenome:FB:FBgn0034091
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8448; Dmel\CG8448; dmrj; dMRJ; MRJ; mrjA
    Summary
    Predicted to enable protein folding chaperone; protein-folding chaperone binding activity; and unfolded protein binding activity. Predicted to be involved in chaperone cofactor-dependent protein refolding. Predicted to be located in cytosol. Predicted to be active in cytoplasm and nucleus. Is expressed in adult head. Human ortholog(s) of this gene implicated in autosomal dominant limb-girdle muscular dystrophy type 1 and autosomal recessive distal hereditary motor neuronopathy 5. Orthologous to several human genes including DNAJB6 (DnaJ heat shock protein family (Hsp40) member B6). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See mrj in Genome Data Viewer
    Location:
    52F8-52F11; 2-78 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (16203329..16221793, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (12090834..12109298, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Lipoyltransferase 1 Neighboring gene SH2 ankyrin repeat kinase Neighboring gene transfer RNA:Glutamine-CTG 1-1 Neighboring gene transfer RNA:Glutamic acid-TTC 1-1 Neighboring gene transfer RNA:Glutamic acid-CTC 1-1 Neighboring gene transfer RNA:Glutamic acid-TTC 1-2 Neighboring gene antisense RNA:CR43898 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Transferrin 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. NPM-hMLF1 fusion protein suppresses defects of a Drosophila FTLD model expressing the human FUS gene. Yamamoto I, et al. Sci Rep, 2018 Jul 26. PMID 30050143, Free PMC Article
    2. A Drosophila ortholog of the human MRJ modulates polyglutamine toxicity and aggregation. Fayazi Z, et al. Neurobiol Dis, 2006 Nov. PMID 16934481
    3. AKT-sensitive or insensitive pathways of toxicity in glial cells and neurons in Drosophila models of Huntington's disease. Liévens JC, et al. Hum Mol Genet, 2008 Mar 15. PMID 18065778
    4. Genetic interaction of hnRNPA2B1 and DNAJB6 in a Drosophila model of multisystem proteinopathy. Li S, et al. Hum Mol Genet, 2016 Mar 1. PMID 26744327, Free PMC Article
    5. Cross-species genetic screens identify transglutaminase 5 as a regulator of polyglutamine-expanded ataxin-1. Lee WS, et al. J Clin Invest, 2022 May 2. PMID 35499073, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mrj is a chaperone of the Hsp40 family that regulates Orb2 oligomerization and long-term memory in Drosophila.
      Title: Mrj is a chaperone of the Hsp40 family that regulates Orb2 oligomerization and long-term memory in Drosophila.
    2. In the retina and other neurons, transgenic dMRJ suppressed polyQ toxicity and colocalized with its inclusions.
      Title: A Drosophila ortholog of the human MRJ modulates polyglutamine toxicity and aggregation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein folding chaperone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-folding chaperone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-folding chaperone binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables unfolded protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in chaperone cofactor-dependent protein refolding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in chaperone-mediated protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chaperone-mediated protein folding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein folding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    mrj
    Names
    CG8448-PA
    CG8448-PB
    CG8448-PC
    CG8448-PD
    CG8448-PE
    CG8448-PF
    CG8448-PG
    CG8448-PH
    mrj-PA
    mrj-PB
    mrj-PC
    mrj-PD
    mrj-PE
    mrj-PF
    mrj-PG
    mrj-PH

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      16203329..16221793 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_166155.3 → NP_725544.1  mrj, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725544.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JUZ6
      Related
      FBpp0086337
      Conserved Domains (2) summary
      COG0484
      Location:2 → 113
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      pfam00226
      Location:3 → 66
      DnaJ; DnaJ domain

    2. NM_001274093.1 → NP_001261022.1  mrj, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261022.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DYF7
      Conserved Domains (2) summary
      COG0484
      Location:2 → 66
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      pfam00226
      Location:3 → 66
      DnaJ; DnaJ domain

    3. NM_166156.4 → NP_725545.2  mrj, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725545.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DYF7
      Conserved Domains (2) summary
      COG0484
      Location:2 → 66
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      pfam00226
      Location:3 → 66
      DnaJ; DnaJ domain

    4. NM_166153.3 → NP_725542.1  mrj, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725542.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JUZ6
      Related
      FBpp0086338
      Conserved Domains (2) summary
      COG0484
      Location:2 → 113
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      pfam00226
      Location:3 → 66
      DnaJ; DnaJ domain

    5. NM_001259435.2 → NP_001246364.1  mrj, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246364.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DYF7
      Conserved Domains (2) summary
      COG0484
      Location:2 → 66
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      pfam00226
      Location:3 → 66
      DnaJ; DnaJ domain

    6. NM_166154.3 → NP_725543.1  mrj, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725543.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JUZ6
      Related
      FBpp0086339
      Conserved Domains (2) summary
      COG0484
      Location:2 → 113
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      pfam00226
      Location:3 → 66
      DnaJ; DnaJ domain

    7. NM_166152.3 → NP_725541.1  mrj, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725541.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JUZ6
      Related
      FBpp0086340
      Conserved Domains (2) summary
      COG0484
      Location:2 → 113
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      pfam00226
      Location:3 → 66
      DnaJ; DnaJ domain

    8. NM_001259434.2 → NP_001246363.1  mrj, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246363.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8WHG9
      Conserved Domains (1) summary
      PRK14294
      Location:9 → 66
      PRK14294; chaperone protein DnaJ; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8DYF7 A8DYF7
    A8WHG9 A8WHG9
    Q7JUZ6 Q7JUZ6

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