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    Syp Syncrip [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42460, updated on 17-Dec-2024

    Summary

    Official Symbol
    Sypprovided by FlyBase
    Official Full Name
    Syncripprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038826
    Locus tag
    Dmel_CG17838
    See related
    AllianceGenome:FB:FBgn0038826
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    AI945337; anon-WO0118547.613; cg17838; CG17838; Dmel\CG17838; l(3)03806; syp
    Summary
    Enables lncRNA binding activity; mRNA 3'-UTR binding activity; and mRNA 5'-UTR binding activity. Involved in several processes, including dorsal appendage formation; negative regulation of synaptic assembly at neuromuscular junction; and post-transcriptional regulation of gene expression. Located in several cellular components, including basal cortex; postsynapse of neuromuscular junction; and ribonucleoprotein granule. Part of precatalytic spliceosome. Is expressed in several structures, including adult head; adult heart; esophagus primordium; foregut primordium; and gonad. Orthologous to human HNRNPR (heterogeneous nuclear ribonucleoprotein R) and SYNCRIP (synaptotagmin binding cytoplasmic RNA interacting protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Syp in Genome Data Viewer
    Location:
    92F12-93A1; 3-69 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (20756729..20810726)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (16582451..16636448)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Proteasome alpha4 subunit, Testis-specific 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Tak1-like 1 Neighboring gene Fancd2 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding  
    enables lncRNA binding PubMed 
    enables mRNA 3'-UTR binding PubMed 
    enables mRNA 5'-UTR binding PubMed 
    enables mRNA binding  
    enables mRNA binding PubMed 
    Component Evidence Code Pubs
    located_in basal cortex PubMed 
    located_in cytosol PubMed 
    is_active_in nucleus  
    located_in nucleus PubMed 
    located_in postsynapse of neuromuscular junction PubMed 
    part_of precatalytic spliceosome PubMed 
    part_of ribonucleoprotein complex  
    located_in ribonucleoprotein granule PubMed 

    General protein information

    Preferred Names
    syncrip
    Names
    CG17838-PA
    CG17838-PB
    CG17838-PC
    CG17838-PD
    CG17838-PE
    CG17838-PF
    CG17838-PH
    CG17838-PI
    CG17838-PJ
    CG17838-PK
    CG17838-PL
    CG17838-PM
    CG17838-PN
    CG17838-PO
    CG17838-PP
    CG17838-PQ
    CG17838-PR
    CG17838-PS
    CG17838-PT
    CG17838-PV
    Syp-PA
    Syp-PB
    Syp-PC
    Syp-PD
    Syp-PE
    Syp-PF
    Syp-PH
    Syp-PI
    Syp-PJ
    Syp-PK
    Syp-PL
    Syp-PM
    Syp-PN
    Syp-PO
    Syp-PP
    Syp-PQ
    Syp-PR
    Syp-PS
    Syp-PT
    Syp-PV

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      20756729..20810726
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275849.1 → NP_001262778.1  syncrip, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262778.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KHH8, Q86NT3
      Conserved Domains (3) summary
      cd12249
      Location:197 → 275
      RRM1_hnRNPR_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein R (hnRNP R) and similar proteins
      cd12250
      Location:278 → 359
      RRM2_hnRNPR_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein R (hnRNP R) and similar proteins
      cd12251
      Location:373 → 444
      RRM3_hnRNPR_like; RNA recognition motif 3 in heterogeneous nuclear ribonucleoprotein R (hnRNP R) and similar proteins
    2. NM_169927.3 → NP_732557.2  syncrip, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732557.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IN47
      Related
      FBpp0083365
      Conserved Domains (3) summary
      cd12249
      Location:197 → 275
      RRM1_hnRNPR_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein R (hnRNP R) and similar proteins
      cd12250
      Location:278 → 359
      RRM2_hnRNPR_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein R (hnRNP R) and similar proteins
      cd12251
      Location:373 → 444
      RRM3_hnRNPR_like; RNA recognition motif 3 in heterogeneous nuclear ribonucleoprotein R (hnRNP R) and similar proteins
    3. NM_001104379.2 → NP_001097849.1  syncrip, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097849.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JR54
      Conserved Domains (3) summary
      cd12249
      Location:168 → 246
      RRM1_hnRNPR_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein R (hnRNP R) and similar proteins
      cd12250
      Location:249 → 330
      RRM2_hnRNPR_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein R (hnRNP R) and similar proteins
      cd12251
      Location:344 → 415
      RRM3_hnRNPR_like; RNA recognition motif 3 in heterogeneous nuclear ribonucleoprotein R (hnRNP R) and similar proteins
    4. NM_001369986.1 → NP_001356920.1  syncrip, isoform S [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4D6K4U6, Q86NT3
      Conserved Domains (1) summary
      TIGR01648
      Location:145 → 547
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
    5. NM_001369987.1 → NP_001356921.1  syncrip, isoform T [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4D6K1Z7
      Conserved Domains (1) summary
      TIGR01648
      Location:145 → 547
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
    6. NM_001275847.1 → NP_001262776.1  syncrip, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262776.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KH21
      Conserved Domains (3) summary
      cd12249
      Location:197 → 275
      RRM1_hnRNPR_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein R (hnRNP R) and similar proteins
      cd12250
      Location:278 → 359
      RRM2_hnRNPR_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein R (hnRNP R) and similar proteins
      cd12251
      Location:373 → 444
      RRM3_hnRNPR_like; RNA recognition motif 3 in heterogeneous nuclear ribonucleoprotein R (hnRNP R) and similar proteins
    7. NM_001275850.1 → NP_001262779.1  syncrip, isoform M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262779.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KGK5, Q86NT3
      Conserved Domains (3) summary
      cd12249
      Location:197 → 275
      RRM1_hnRNPR_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein R (hnRNP R) and similar proteins
      cd12250
      Location:278 → 359
      RRM2_hnRNPR_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein R (hnRNP R) and similar proteins
      cd12251
      Location:373 → 444
      RRM3_hnRNPR_like; RNA recognition motif 3 in heterogeneous nuclear ribonucleoprotein R (hnRNP R) and similar proteins
    8. NM_142656.4 → NP_650913.2  syncrip, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650913.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JR56, Q7KSA0, Q86NT3
      Conserved Domains (3) summary
      cd12249
      Location:163 → 241
      RRM1_hnRNPR_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein R (hnRNP R) and similar proteins
      cd12250
      Location:244 → 325
      RRM2_hnRNPR_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein R (hnRNP R) and similar proteins
      cd12251
      Location:339 → 410
      RRM3_hnRNPR_like; RNA recognition motif 3 in heterogeneous nuclear ribonucleoprotein R (hnRNP R) and similar proteins
    9. NM_001275851.1 → NP_001262780.1  syncrip, isoform N [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262780.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KGF9, Q86NT3
      Conserved Domains (3) summary
      cd12249
      Location:163 → 241
      RRM1_hnRNPR_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein R (hnRNP R) and similar proteins
      cd12250
      Location:244 → 325
      RRM2_hnRNPR_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein R (hnRNP R) and similar proteins
      cd12251
      Location:339 → 410
      RRM3_hnRNPR_like; RNA recognition motif 3 in heterogeneous nuclear ribonucleoprotein R (hnRNP R) and similar proteins
    10. NM_001275855.1 → NP_001262784.1  syncrip, isoform R [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262784.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KGK8
      Conserved Domains (3) summary
      cd12249
      Location:163 → 241
      RRM1_hnRNPR_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein R (hnRNP R) and similar proteins
      cd12250
      Location:244 → 325
      RRM2_hnRNPR_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein R (hnRNP R) and similar proteins
      cd12251
      Location:339 → 410
      RRM3_hnRNPR_like; RNA recognition motif 3 in heterogeneous nuclear ribonucleoprotein R (hnRNP R) and similar proteins
    11. NM_169928.3 → NP_732558.2  syncrip, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732558.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KSA1, Q95TW4
      Conserved Domains (3) summary
      cd12249
      Location:163 → 241
      RRM1_hnRNPR_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein R (hnRNP R) and similar proteins
      cd12250
      Location:244 → 325
      RRM2_hnRNPR_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein R (hnRNP R) and similar proteins
      cd12251
      Location:339 → 410
      RRM3_hnRNPR_like; RNA recognition motif 3 in heterogeneous nuclear ribonucleoprotein R (hnRNP R) and similar proteins
    12. NM_169929.3 → NP_732559.1  syncrip, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732559.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4V364
      Related
      FBpp0083368
      Conserved Domains (3) summary
      cd12249
      Location:163 → 241
      RRM1_hnRNPR_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein R (hnRNP R) and similar proteins
      cd12250
      Location:244 → 325
      RRM2_hnRNPR_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein R (hnRNP R) and similar proteins
      cd12251
      Location:339 → 410
      RRM3_hnRNPR_like; RNA recognition motif 3 in heterogeneous nuclear ribonucleoprotein R (hnRNP R) and similar proteins
    13. NM_001104378.2 → NP_001097848.2  syncrip, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097848.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JR56, Q7KSA0, Q86NT3
      Conserved Domains (3) summary
      cd12249
      Location:163 → 241
      RRM1_hnRNPR_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein R (hnRNP R) and similar proteins
      cd12250
      Location:244 → 325
      RRM2_hnRNPR_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein R (hnRNP R) and similar proteins
      cd12251
      Location:339 → 410
      RRM3_hnRNPR_like; RNA recognition motif 3 in heterogeneous nuclear ribonucleoprotein R (hnRNP R) and similar proteins
    14. NM_001275853.1 → NP_001262782.1  syncrip, isoform P [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262782.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KGF9, Q86NT3
      Conserved Domains (3) summary
      cd12249
      Location:163 → 241
      RRM1_hnRNPR_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein R (hnRNP R) and similar proteins
      cd12250
      Location:244 → 325
      RRM2_hnRNPR_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein R (hnRNP R) and similar proteins
      cd12251
      Location:339 → 410
      RRM3_hnRNPR_like; RNA recognition motif 3 in heterogeneous nuclear ribonucleoprotein R (hnRNP R) and similar proteins
    15. NM_169925.3 → NP_732555.1  syncrip, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732555.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C6SV30, Q8IN48
      Related
      FBpp0083370
      Conserved Domains (2) summary
      TIGR01648
      Location:153 → 508
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
      cd21065
      Location:68 → 150
      NURR_Syncrip-like; NURR (N-terminal unit for RNA recognition) domain found in Drosophila melanogaster Syncrip and similar proteins
    16. NM_001275854.1 → NP_001262783.1  syncrip, isoform Q [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262783.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KHI4, Q86NT3
      Conserved Domains (3) summary
      cd12249
      Location:205 → 283
      RRM1_hnRNPR_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein R (hnRNP R) and similar proteins
      cd12250
      Location:286 → 367
      RRM2_hnRNPR_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein R (hnRNP R) and similar proteins
      cd12251
      Location:381 → 452
      RRM3_hnRNPR_like; RNA recognition motif 3 in heterogeneous nuclear ribonucleoprotein R (hnRNP R) and similar proteins
    17. NM_001275848.1 → NP_001262777.1  syncrip, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262777.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KHT5, Q86NT3
      Conserved Domains (3) summary
      cd12249
      Location:205 → 283
      RRM1_hnRNPR_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein R (hnRNP R) and similar proteins
      cd12250
      Location:286 → 367
      RRM2_hnRNPR_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein R (hnRNP R) and similar proteins
      cd12251
      Location:381 → 452
      RRM3_hnRNPR_like; RNA recognition motif 3 in heterogeneous nuclear ribonucleoprotein R (hnRNP R) and similar proteins
    18. NM_169926.2 → NP_732556.1  syncrip, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732556.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86NT3, Q9VDI8
      Related
      FBpp0083369
      Conserved Domains (3) summary
      cd12249
      Location:205 → 283
      RRM1_hnRNPR_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein R (hnRNP R) and similar proteins
      cd12250
      Location:286 → 367
      RRM2_hnRNPR_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein R (hnRNP R) and similar proteins
      cd12251
      Location:381 → 452
      RRM3_hnRNPR_like; RNA recognition motif 3 in heterogeneous nuclear ribonucleoprotein R (hnRNP R) and similar proteins
    19. NM_001369988.1 → NP_001356922.1  syncrip, isoform V [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4D6K3P4
      Conserved Domains (1) summary
      TIGR01648
      Location:153 → 555
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
    20. NM_001275852.1 → NP_001262781.1  syncrip, isoform O [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262781.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KH24
      Conserved Domains (3) summary
      cd12249
      Location:205 → 283
      RRM1_hnRNPR_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein R (hnRNP R) and similar proteins
      cd12250
      Location:286 → 367
      RRM2_hnRNPR_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein R (hnRNP R) and similar proteins
      cd12251
      Location:381 → 452
      RRM3_hnRNPR_like; RNA recognition motif 3 in heterogeneous nuclear ribonucleoprotein R (hnRNP R) and similar proteins
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