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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
Genomic
-
NG_027813.1 RefSeqGene
- Range
-
5001..95335
- Download
- GenBank, FASTA, Sequence Viewer (Graphics), LRG_613
mRNA and Protein(s)
-
NM_001197104.2 → NP_001184033.1 histone-lysine N-methyltransferase 2A isoform 1
Status: REVIEWED
- Description
- Transcript Variant: This variant (1) lacks an alternate in-frame exon compared to variant 3. The resulting isoform (1) has the same N- and C-termini but is shorter compared to isoform 3.
- Source sequence(s)
-
AI500057, AP000941, AP001267, BC065385, D14540, L04731
- Consensus CDS
-
CCDS55791.1
- UniProtKB/TrEMBL
-
A0A8I5KXR3
- Related
- ENSP00000436786.2, ENST00000534358.8
- Conserved Domains (9) summary
-
- cd05493
Location:1650 → 1780
- Bromo_ALL-1; Bromodomain, ALL-1 like proteins. ALL-1 is a vertebrate homologue of Drosophila trithorax and is often affected in chromosomal rearrangements that are linked to acute leukemias, such as acute lymphocytic leukemia (ALL). Bromodomains are found in many ...
- smart00542
Location:3672 → 3755
- FYRC; FY-rich domain, C-terminal region
- cd15588
Location:1433 → 1479
- PHD1_KMT2A; PHD finger 1 found in histone-lysine N-methyltransferase 2A (KMT2A)
- cd15590
Location:1481 → 1530
- PHD2_KMT2A; PHD finger 2 found in histone-lysine N-methyltransferase 2A (KMT2A)
- cd15592
Location:1568 → 1627
- PHD3_KMT2A; PHD finger 3 found in histone-lysine N-methyltransferase 2A (KMT2A)
- cd15693
Location:1874 → 1986
- ePHD_KMT2A; Extended PHD finger found in histone-lysine N-methyltransferase 2A (KMT2A)
- pfam02008
Location:1147 → 1194
- zf-CXXC; CXXC zinc finger domain
- pfam05964
Location:2027 → 2074
- FYRN; F/Y-rich N-terminus
- cd19170
Location:3819 → 3972
- SET_KMT2A_2B; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B) and similar proteins
-
NM_001412597.1 → NP_001399526.1 histone-lysine N-methyltransferase 2A isoform 3
Status: REVIEWED
- Description
- Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).
- Source sequence(s)
-
AP000941, AP001267
- UniProtKB/TrEMBL
- A0A8I5KXR3, A0AA34QVI8
- Related
- ENSP00000518343.1, ENST00000710560.1
-
NM_005933.4 → NP_005924.2 histone-lysine N-methyltransferase 2A isoform 2 precursor
See identical proteins and their annotated locations for NP_005924.2
Status: REVIEWED
- Description
- Transcript Variant: This variant (2) lacks an alternate in-frame exon and uses an alternate in-frame splice site in the coding region, compared to variant 3. This results in a shorter protein (isoform 2), compared to isoform 3.
- Source sequence(s)
-
AB209508, AP000941, AP001267, BC065385, D14540
- Consensus CDS
-
CCDS31686.1
- UniProtKB/Swiss-Prot
- E9PQG7, Q03164, Q13743, Q13744, Q14845, Q16364, Q59FF2, Q6UBD1, Q9HBJ3, Q9UD94, Q9UMA3
- UniProtKB/TrEMBL
-
A0A8I5KXR3
- Related
- ENSP00000374157.5, ENST00000389506.10
- Conserved Domains (11) summary
-
- cd05493
Location:1647 → 1777
- Bromo_ALL-1; Bromodomain, ALL-1 like proteins. ALL-1 is a vertebrate homologue of Drosophila trithorax and is often affected in chromosomal rearrangements that are linked to acute leukemias, such as acute lymphocytic leukemia (ALL). Bromodomains are found in many ...
- smart00542
Location:3669 → 3752
- FYRC; FY-rich domain, C-terminal region
- smart00317
Location:3831 → 3951
- SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
- smart00508
Location:3953 → 3969
- PostSET; Cysteine-rich motif following a subset of SET domains
- COG2940
Location:3825 → 3969
- SET; SET domain-containing protein (function unknown) [General function prediction only]
- pfam02008
Location:1147 → 1194
- zf-CXXC; CXXC zinc finger domain
- cd15588
Location:1433 → 1479
- PHD1_KMT2A; PHD finger 1 found in histone-lysine N-methyltransferase 2A (KMT2A)
- cd15590
Location:1481 → 1530
- PHD2_KMT2A; PHD finger 2 found in histone-lysine N-methyltransferase 2A (KMT2A)
- cd15592
Location:1568 → 1624
- PHD3_KMT2A; PHD finger 3 found in histone-lysine N-methyltransferase 2A (KMT2A)
- cd15693
Location:1871 → 1983
- ePHD_KMT2A; Extended PHD finger found in histone-lysine N-methyltransferase 2A (KMT2A)
- pfam05964
Location:2025 → 2071
- FYRN; F/Y-rich N-terminus
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCh38.p14 Primary Assembly
Genomic
-
NC_000011.10 Reference GRCh38.p14 Primary Assembly
- Range
-
118436492..118526832
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_011542829.3 → XP_011541131.1 histone-lysine N-methyltransferase 2A isoform X1
- UniProtKB/TrEMBL
- A0A8I5KXR3, E9PR05
- Related
- ENSP00000432391.3, ENST00000531904.7
- Conserved Domains (11) summary
-
- cd05493
Location:1683 → 1813
- Bromo_ALL-1; Bromodomain, ALL-1 like proteins. ALL-1 is a vertebrate homologue of Drosophila trithorax and is often affected in chromosomal rearrangements that are linked to acute leukemias, such as acute lymphocytic leukemia (ALL). Bromodomains are found in many ...
- smart00542
Location:3705 → 3788
- FYRC; FY-rich domain, C-terminal region
- smart00317
Location:3867 → 3987
- SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
- smart00508
Location:3989 → 4005
- PostSET; Cysteine-rich motif following a subset of SET domains
- COG2940
Location:3861 → 4005
- SET; SET domain-containing protein (function unknown) [General function prediction only]
- pfam02008
Location:1180 → 1227
- zf-CXXC; CXXC zinc finger domain
- cd15588
Location:1466 → 1512
- PHD1_KMT2A; PHD finger 1 found in histone-lysine N-methyltransferase 2A (KMT2A)
- cd15590
Location:1514 → 1563
- PHD2_KMT2A; PHD finger 2 found in histone-lysine N-methyltransferase 2A (KMT2A)
- cd15592
Location:1601 → 1660
- PHD3_KMT2A; PHD finger 3 found in histone-lysine N-methyltransferase 2A (KMT2A)
- cd15693
Location:1907 → 2019
- ePHD_KMT2A; Extended PHD finger found in histone-lysine N-methyltransferase 2A (KMT2A)
- pfam05964
Location:2061 → 2107
- FYRN; F/Y-rich N-terminus
-
XM_011542830.3 → XP_011541132.1 histone-lysine N-methyltransferase 2A isoform X2
- UniProtKB/TrEMBL
-
A0A8I5KXR3
- Conserved Domains (11) summary
-
- cd05493
Location:1682 → 1812
- Bromo_ALL-1; Bromodomain, ALL-1 like proteins. ALL-1 is a vertebrate homologue of Drosophila trithorax and is often affected in chromosomal rearrangements that are linked to acute leukemias, such as acute lymphocytic leukemia (ALL). Bromodomains are found in many ...
- smart00542
Location:3704 → 3787
- FYRC; FY-rich domain, C-terminal region
- smart00317
Location:3866 → 3986
- SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
- smart00508
Location:3988 → 4004
- PostSET; Cysteine-rich motif following a subset of SET domains
- COG2940
Location:3860 → 4004
- SET; SET domain-containing protein (function unknown) [General function prediction only]
- pfam02008
Location:1180 → 1227
- zf-CXXC; CXXC zinc finger domain
- cd15588
Location:1466 → 1512
- PHD1_KMT2A; PHD finger 1 found in histone-lysine N-methyltransferase 2A (KMT2A)
- cd15590
Location:1514 → 1562
- PHD2_KMT2A; PHD finger 2 found in histone-lysine N-methyltransferase 2A (KMT2A)
- cd15592
Location:1600 → 1659
- PHD3_KMT2A; PHD finger 3 found in histone-lysine N-methyltransferase 2A (KMT2A)
- cd15693
Location:1906 → 2018
- ePHD_KMT2A; Extended PHD finger found in histone-lysine N-methyltransferase 2A (KMT2A)
- pfam05964
Location:2060 → 2106
- FYRN; F/Y-rich N-terminus
-
XM_047426963.1 → XP_047282919.1 histone-lysine N-methyltransferase 2A isoform X3
- UniProtKB/TrEMBL
-
A0A8I5KXR3
-
XM_011542833.3 → XP_011541135.1 histone-lysine N-methyltransferase 2A isoform X4
- Conserved Domains (11) summary
-
- cd05493
Location:844 → 974
- Bromo_ALL-1; Bromodomain, ALL-1 like proteins. ALL-1 is a vertebrate homologue of Drosophila trithorax and is often affected in chromosomal rearrangements that are linked to acute leukemias, such as acute lymphocytic leukemia (ALL). Bromodomains are found in many ...
- smart00542
Location:2866 → 2949
- FYRC; FY-rich domain, C-terminal region
- smart00317
Location:3028 → 3148
- SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
- smart00508
Location:3150 → 3166
- PostSET; Cysteine-rich motif following a subset of SET domains
- COG2940
Location:3014 → 3166
- SET; SET domain-containing protein (function unknown) [General function prediction only]
- pfam02008
Location:341 → 388
- zf-CXXC; CXXC zinc finger domain
- cd15588
Location:627 → 673
- PHD1_KMT2A; PHD finger 1 found in histone-lysine N-methyltransferase 2A (KMT2A)
- cd15590
Location:675 → 724
- PHD2_KMT2A; PHD finger 2 found in histone-lysine N-methyltransferase 2A (KMT2A)
- cd15592
Location:762 → 821
- PHD3_KMT2A; PHD finger 3 found in histone-lysine N-methyltransferase 2A (KMT2A)
- cd15693
Location:1068 → 1180
- ePHD_KMT2A; Extended PHD finger found in histone-lysine N-methyltransferase 2A (KMT2A)
- pfam05964
Location:1222 → 1268
- FYRN; F/Y-rich N-terminus
-
XM_006718839.4 → XP_006718902.2 histone-lysine N-methyltransferase 2A isoform X5
- Conserved Domains (11) summary
-
- cd05493
Location:811 → 941
- Bromo_ALL-1; Bromodomain, ALL-1 like proteins. ALL-1 is a vertebrate homologue of Drosophila trithorax and is often affected in chromosomal rearrangements that are linked to acute leukemias, such as acute lymphocytic leukemia (ALL). Bromodomains are found in many ...
- smart00542
Location:2833 → 2916
- FYRC; FY-rich domain, C-terminal region
- smart00317
Location:2995 → 3115
- SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
- smart00508
Location:3117 → 3133
- PostSET; Cysteine-rich motif following a subset of SET domains
- COG2940
Location:2981 → 3133
- SET; SET domain-containing protein (function unknown) [General function prediction only]
- pfam02008
Location:308 → 355
- zf-CXXC; CXXC zinc finger domain
- cd15588
Location:594 → 640
- PHD1_KMT2A; PHD finger 1 found in histone-lysine N-methyltransferase 2A (KMT2A)
- cd15590
Location:642 → 691
- PHD2_KMT2A; PHD finger 2 found in histone-lysine N-methyltransferase 2A (KMT2A)
- cd15592
Location:729 → 788
- PHD3_KMT2A; PHD finger 3 found in histone-lysine N-methyltransferase 2A (KMT2A)
- cd15693
Location:1035 → 1147
- ePHD_KMT2A; Extended PHD finger found in histone-lysine N-methyltransferase 2A (KMT2A)
- pfam05964
Location:1189 → 1235
- FYRN; F/Y-rich N-terminus
-
XM_047426964.1 → XP_047282920.1 histone-lysine N-methyltransferase 2A isoform X6
Alternate T2T-CHM13v2.0
Genomic
-
NC_060935.1 Alternate T2T-CHM13v2.0
- Range
-
118455794..118546121
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_054368830.1 → XP_054224805.1 histone-lysine N-methyltransferase 2A isoform X1
- UniProtKB/TrEMBL
- A0A8I5KXR3, E9PR05
-
XM_054368831.1 → XP_054224806.1 histone-lysine N-methyltransferase 2A isoform X2
- UniProtKB/TrEMBL
-
A0A8I5KXR3
-
XM_054368832.1 → XP_054224807.1 histone-lysine N-methyltransferase 2A isoform X3
- UniProtKB/TrEMBL
-
A0A8I5KXR3
-
XM_054368833.1 → XP_054224808.1 histone-lysine N-methyltransferase 2A isoform X4
-
XM_054368834.1 → XP_054224809.1 histone-lysine N-methyltransferase 2A isoform X5
-
XM_054368835.1 → XP_054224810.1 histone-lysine N-methyltransferase 2A isoform X6
The following Reference Sequences have been suppressed. Explain
These RefSeqs were suppressed for the
cited reason(s). Suppressed RefSeqs do not appear in BLAST databases, related
sequence links, or BLAST links (BLink), but may still be retrieved by clicking on
their accession.version below.
-
NM_024891.2: Suppressed sequence
- Description
- NM_024891.2: This RefSeq was permanently suppressed because it is primarily intronic sequence.