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    ade2 adenylosuccinate synthetase Ade2 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2542823, updated on 14-Nov-2024

    Summary

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    Official Symbol
    ade2
    Official Full Name
    adenylosuccinate synthetase Ade2
    Primary source
    PomBase:SPAC144.03
    Locus tag
    SPOM_SPAC144.03
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    min10; min3
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    Genomic context

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    See ade2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    3
    Sequence:
    Chromosome: I; NC_003424.3 (4654631..4656456)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene Schizosaccharomyces specific protein Neighboring gene ncRNA Neighboring gene Ino80 complex subunit Iec1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ornithine decarboxylase Spe1 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Regulation of the biosynthesis of purine nucleotides in Schizosaccharomyces pombe. 3. Kinetic studies of adenylosuccinate synthetase. Nagy M, et al. Biochim Biophys Acta, 1973 May 5. PMID 4708672
    2. Two purine biosynthetic enzymes that are required for cadmium tolerance in Schizosaccharomyces pombe utilize cysteine sulfinate in vitro. Juang RH, et al. Arch Biochem Biophys, 1993 Aug 1. PMID 8346915
    3. Purine biosynthetic genes are required for cadmium tolerance in Schizosaccharomyces pombe. Speiser DM, et al. Mol Cell Biol, 1992 Dec. PMID 1448066, Free PMC Article
    4. A non-transcriptional role for the glucocorticoid receptor in mediating the cell stress response. Ptushkina M, et al. Sci Rep, 2017 Sep 21. PMID 28935859, Free PMC Article
    5. Genetic interactions and functional analyses of the fission yeast gsk3 and amk2 single and double mutants defective in TORC1-dependent processes. Rallis C, et al. Sci Rep, 2017 Mar 10. PMID 28281664, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables AMP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GMP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables adenylosuccinate synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables adenylosuccinate synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 'de novo' AMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in 'de novo' AMP biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in 'de novo' AMP biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in IMP metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in adenosine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to cadmium ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in purine nucleotide biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol HDA PubMed 
    is_active_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    adenylosuccinate synthetase Ade2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      4654631..4656456
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001020093.3 → NP_594664.1  adenylosuccinate synthetase Ade2 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_594664.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P79061, Q02787
      Conserved Domains (1) summary
      pfam00709
      Location:18 → 431
      Adenylsucc_synt; Adenylosuccinate synthetase
    Nucleotide Protein
    Heading Accession and Version

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