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    ROX3 Rox3p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852184, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ROX3
    Official Full Name
    Rox3p
    Primary source
    SGD:S000000189
    Locus tag
    YBL093C
    See related
    AllianceGenome:SGD:S000000189; FungiDB:YBL093C; VEuPathDB:YBL093C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    MED19; NUT3; RMR1; SSN7; SSX2
    Summary
    Enables transcription coactivator activity. Involved in regulation of transcription by RNA polymerase II and transcription initiation at RNA polymerase II promoter. Located in nucleus. Part of core mediator complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ROX3 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (44256..44918, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene condensin subunit BRN1 Neighboring gene Mrx3p Neighboring gene ribosomal 60S subunit protein L32 Neighboring gene phospholipid metabolism-regulating protein SCS22

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The ROX3 gene encodes an essential nuclear protein involved in CYC7 gene expression in Saccharomyces cerevisiae. Rosenblum-Vos LS, et al. Mol Cell Biol, 1991 Nov. PMID 1656237, Free PMC Article
    2. Rox3 and Rts1 function in the global stress response pathway in baker's yeast. Evangelista CC Jr, et al. Genetics, 1996 Apr. PMID 8846889, Free PMC Article
    3. Simultaneous recruitment of coactivators by Gcn4p stimulates multiple steps of transcription in vivo. Govind CK, et al. Mol Cell Biol, 2005 Jul. PMID 15964818, Free PMC Article
    4. Regulation of nuclear genes encoding mitochondrial proteins in Saccharomyces cerevisiae. Brown TA, et al. J Bacteriol, 1995 Dec. PMID 7592476, Free PMC Article
    5. Activation of a poised RNAPII-dependent promoter requires both SAGA and mediator. Lee SK, et al. Genetics, 2010 Mar. PMID 20048049, Free PMC Article

    See all (79) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables transcription coactivator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coregulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA polymerase II preinitiation complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transcription open complex formation at RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of core mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of core mediator complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mediator complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Rox3p
    NP_009459.1
    • Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      44256..44918 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178333.1 → NP_009459.1  TPA: Rox3p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009459.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VPR0, P25046
      UniProtKB/TrEMBL
      A6ZKK9, B3LNM5, B5VDP9, C7GSF0, C8Z3V1, G2W8R9, N1P7Z0
      Conserved Domains (1) summary
      pfam08633
      Location:26 → 219
      Rox3; Rox3 mediator complex subunit
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25046.3

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