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    imp1 importin alpha family nuclear import signal receptor adaptor Imp1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2539928, updated on 18-Sep-2024

    Summary

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    Official Symbol
    imp1
    Official Full Name
    importin alpha family nuclear import signal receptor adaptor Imp1
    Primary source
    PomBase:SPBC1604.08c
    Locus tag
    SPOM_SPBC1604.08C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See imp1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_003423.3 (3916555..3918514)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene tRNA-Leu Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene exoribonuclease Rex4 Neighboring gene ncRNA Neighboring gene F0-ATPase subunit atp4 Neighboring gene Mak21 family protein Neighboring gene ncRNA Neighboring gene glucose-6-phosphate isomerase Neighboring gene thiamine pyrophosphate transporter

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome-wide search of Schizosaccharomyces pombe genes causing overexpression-mediated cell cycle defects. Tallada VA, et al. Yeast, 2002 Sep 30. PMID 12237855
    2. Importin α and vNEBD Control Meiotic Spindle Disassembly in Fission Yeast. Flor-Parra I, et al. Cell Rep, 2018 Apr 24. PMID 29694900
    3. The fission yeast Schizosaccharomyces pombe has two importin-alpha proteins, Imp1p and Cut15p, which have common and unique functions in nucleocytoplasmic transport and cell cycle progression. Umeda M, et al. Genetics, 2005 Sep. PMID 15937127, Free PMC Article
    4. Latrunculin A-Induced Perturbation of the Actin Cytoskeleton Mediates Pap1p-Dependent Induction of the Caf5p Efflux Pump in Schizosaccharomyces pombe. Asadi F, et al. G3 (Bethesda), 2017 Feb 9. PMID 28040778, Free PMC Article
    5. Characterization of the nuclear import mechanism of the CCAAT-regulatory subunit Php4. Khan MG, et al. PLoS One, 2014. PMID 25330182, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. these results suggest a model in which LatA-mediated cytoskeletal perturbations are sensed, triggering the Imp1p-dependent translocation of Pap1p to the nucleus and the induction of the caf5 gene (independently of oxidative stress).
      Title: Latrunculin A-Induced Perturbation of the Actin Cytoskeleton Mediates Pap1p-Dependent Induction of the Caf5p Efflux Pump in Schizosaccharomyces pombe.
    2. Further analysis by pull-down experiments revealed that Php4 is a cargo of the karyopherins Imp1, Cut15 and Sal3.
      Title: Characterization of the nuclear import mechanism of the CCAAT-regulatory subunit Php4.
    3. Imp1p is essential for efficient nuclear protein import in S. pombe.
      Title: The fission yeast Schizosaccharomyces pombe has two importin-alpha proteins, Imp1p and Cut15p, which have common and unique functions in nucleocytoplasmic transport and cell cycle progression.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables GTP binding NAS
    Non-traceable Author Statement
    more info
    		  
    enables nuclear import signal receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear import signal receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nuclear import signal receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables nuclear localization sequence binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in NLS-bearing protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in NLS-bearing protein import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic nuclear pore complex disassembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein import into nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of mitotic nuclear envelope disassembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol HDA PubMed 
    is_active_in mitotic spindle midzone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nuclear envelope HDA PubMed 
    is_active_in nuclear periphery IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nuclear pore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    importin alpha family nuclear import signal receptor adaptor Imp1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      3916555..3918514
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001022553.3 → NP_596632.1  importin alpha family nuclear import signal receptor adaptor Imp1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_596632.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O94374
      Conserved Domains (5) summary
      COG5064
      Location:1 → 531
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00020
      Location:114 → 235
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam01749
      Location:9 → 99
      IBB; Importin beta binding domain
      pfam16186
      Location:462 → 508
      Arm_3; Atypical Arm repeat
      sd00043
      Location:115 → 147
      ARM; armadillo repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version

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