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    FRE8 putative ferric-chelate reductase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850736, updated on 9-Dec-2024

    Summary

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    Official Symbol
    FRE8
    Official Full Name
    putative ferric-chelate reductase
    Primary source
    SGD:S000004037
    Locus tag
    YLR047C
    See related
    AllianceGenome:SGD:S000004037; FungiDB:YLR047C; VEuPathDB:YLR047C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables oxidoreductase activity, acting on metal ions. Involved in intracellular monoatomic cation homeostasis. Located in endoplasmic reticulum and fungal-type vacuole membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See FRE8 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (239347..241407, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Stu2p Neighboring gene uncharacterized protein Neighboring gene ribosomal 40S subunit protein S0B Neighboring gene Mlo50p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Exploratory and confirmatory gene expression profiling of mac1Delta. De Freitas JM, et al. J Biol Chem, 2004 Feb 6. PMID 14534306
    2. Regulated expression of the Saccharomyces cerevisiae Fre1p/Fre2p Fe/Cu reductase related genes. Georgatsou E, et al. Yeast, 1999 May. PMID 10341420
    3. Mitochondrial ribosomal proteins involved in tellurite resistance in yeast Saccharomyces cerevisiae. Pontieri P, et al. Sci Rep, 2018 Aug 13. PMID 30104660, Free PMC Article
    4. The yeast vacuolar membrane proteome. Wiederhold E, et al. Mol Cell Proteomics, 2009 Feb. PMID 19001347
    5. Exploring the yeast acetylome using functional genomics. Kaluarachchi Duffy S, et al. Cell, 2012 May 11. PMID 22579291, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ferric-chelate reductase (NADH) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ferric-chelate reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on metal ions IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intracellular monoatomic cation homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in iron ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in reductive iron assimilation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in fungal-type vacuole membrane HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    putative ferric-chelate reductase
    NP_013148.1
    • Protein with sequence similarity to iron/copper reductases; involved in iron homeostasis; deletion mutant has iron deficiency/accumulation growth defects; expression increased in the absence of copper-responsive transcription factor Mac1p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      239347..241407 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181934.1 → NP_013148.1  TPA: putative ferric-chelate reductase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013148.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VY49, Q12209
      UniProtKB/TrEMBL
      A7A0V2, B3LT18, C7GT71, G2WIP0
      Conserved Domains (2) summary
      cd06186
      Location:265 → 459
      NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
      pfam01794
      Location:122 → 232
      Ferric_reduct; Ferric reductase like transmembrane component
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12209.1

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