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    ADRA2A adrenoceptor alpha 2A [ Homo sapiens (human) ]

    Gene ID: 150, updated on 10-Dec-2024

    Summary

    Official Symbol
    ADRA2Aprovided by HGNC
    Official Full Name
    adrenoceptor alpha 2Aprovided by HGNC
    Primary source
    HGNC:HGNC:281
    See related
    Ensembl:ENSG00000150594 MIM:104210; AllianceGenome:HGNC:281
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ADRA2; ADRAR; FPLD8; ZNF32; ADRA2R; ALPHA2AAR
    Summary
    Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. The alpha-2-adrenergic receptors are a type of adrenergic receptors (for adrenaline or epinephrine), which inhibit adenylate cyclase. These receptors include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. They are involved in regulating the release of neurotransmitter molecules from sympathetic nerves and from adrenergic neurons in the central nervous system. The sympathetic nervous system regulates cardiovascular function by activating adrenergic receptors in the heart, blood vessels and kidney. Studies in mouse revealed that both the alpha2A and alpha2C receptor subtypes were required for presynaptic transmitter release from the sympathetic nervous system in the heart and from central noradrenergic neurons. The alpha-2-adrenergic receptors are also involved in catecholamine signaling by extracellular regulated protein kinase 1 and 2 (ERK1/2) pathways. A clear association between the alpha-2-adrenergic receptor and disease has not been yet established. [provided by RefSeq, Sep 2019]
    Orthologs
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    Genomic context

    See ADRA2A in Genome Data Viewer
    Location:
    10q25.2
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (111077029..111080907)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (111960874..111964752)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (112836787..112840665)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene SHOC2 leucine rich repeat scaffold protein Neighboring gene ribosomal protein L13a pseudogene 6 Neighboring gene microRNA 548e Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2830 Neighboring gene chromosome 19 open reading frame 53 pseudogene Neighboring gene HEart disease Associated Transcript 2

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (10 hits/1258 screens)

    Associated conditions

    Description Tests
    Lipodystrophy, familial partial, type 8
    MedGen: C5882744 OMIM: 620679 GeneReviews: Not available
    not available

    EBI GWAS Catalog

    Description
    A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.
    EBI GWAS Catalog
    Genome-wide meta-analyses identifies seven loci associated with platelet aggregation in response to agonists.
    EBI GWAS Catalog
    New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables alpha-1B adrenergic receptor binding  
    enables alpha-2C adrenergic receptor binding PubMed 
    enables alpha2-adrenergic receptor activity PubMed 
    enables alpha2-adrenergic receptor activity  
    enables alpha2-adrenergic receptor activity PubMed 
    enables alpha2-adrenergic receptor activity PubMed 
    enables epinephrine binding  
    enables epinephrine binding PubMed 
    enables guanyl-nucleotide exchange factor activity  
    enables heterotrimeric G-protein binding PubMed 
    enables norepinephrine binding PubMed 
    enables protein binding PubMed 
    enables protein heterodimerization activity PubMed 
    enables protein heterodimerization activity  
    enables protein homodimerization activity PubMed 
    enables protein kinase binding PubMed 
    enables thioesterase binding PubMed 
    Items 1 - 25 of 47
    Process Evidence Code Pubs
    involved_in DNA replication  
    involved_in G protein-coupled receptor signaling pathway PubMed 
    involved_in G protein-coupled receptor signaling pathway PubMed 
    involved_in Ras protein signal transduction PubMed 
    involved_in Rho protein signal transduction PubMed 
    involved_in actin cytoskeleton organization PubMed 
    involved_in activation of protein kinase B activity PubMed 
    involved_in activation of protein kinase activity PubMed 
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway PubMed 
    involved_in adenylate cyclase-activating adrenergic receptor signaling pathway  
    involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway PubMed 
    involved_in adenylate cyclase-inhibiting adrenergic receptor signaling pathway PubMed 
    involved_in adrenergic receptor signaling pathway PubMed 
    involved_in cellular response to hormone stimulus PubMed 
    involved_in fear response  
    involved_in female pregnancy  
    involved_in glucose homeostasis PubMed 
    involved_in intestinal absorption PubMed 
    involved_in negative regulation of calcium ion transmembrane transporter activity PubMed 
    involved_in negative regulation of calcium ion transport  
    involved_in negative regulation of calcium ion-dependent exocytosis PubMed 
    involved_in negative regulation of epinephrine secretion PubMed 
    involved_in negative regulation of insulin secretion PubMed 
    involved_in negative regulation of insulin secretion  
    involved_in negative regulation of insulin secretion involved in cellular response to glucose stimulus PubMed 
    involved_in negative regulation of lipid catabolic process PubMed 
    involved_in negative regulation of norepinephrine secretion PubMed 
    involved_in negative regulation of norepinephrine secretion PubMed 
    involved_in negative regulation of uterine smooth muscle contraction  
    involved_in phospholipase C-activating adrenergic receptor signaling pathway PubMed 
    involved_in platelet activation  
    involved_in positive regulation of MAP kinase activity PubMed 
    involved_in positive regulation of MAPK cascade PubMed 
    involved_in positive regulation of cell migration PubMed 
    involved_in positive regulation of cell population proliferation PubMed 
    involved_in positive regulation of cytokine production PubMed 
    involved_in positive regulation of epidermal growth factor receptor signaling pathway PubMed 
    involved_in positive regulation of membrane protein ectodomain proteolysis PubMed 
    involved_in positive regulation of potassium ion transport PubMed 
    involved_in positive regulation of wound healing PubMed 
    involved_in presynaptic modulation of chemical synaptic transmission  
    involved_in receptor transactivation PubMed 
    involved_in regulation of vasoconstriction  
    involved_in response to alcohol  
    involved_in response to morphine  
    involved_in thermoception  
    involved_in vasodilation  
    Items 1 - 25 of 47
    Component Evidence Code Pubs
    located_in GABA-ergic synapse  
    located_in axon terminus  
    located_in basolateral plasma membrane PubMed 
    located_in cytoplasm PubMed 
    located_in dopaminergic synapse  
    located_in glutamatergic synapse  
    located_in neuronal cell body  
    is_active_in plasma membrane  
    located_in plasma membrane PubMed 
    located_in plasma membrane  
    located_in postsynaptic density membrane  
    located_in presynaptic active zone membrane  
    part_of receptor complex PubMed 

    General protein information

    Preferred Names
    alpha-2A adrenergic receptor
    Names
    adrenergic, alpha-2A-, receptor
    alpha-2 adrenergic receptor subtype C10
    alpha-2-adrenergic receptor, platelet type
    alpha-2A adrenoceptor
    alpha-2A adrenoreceptor
    alpha-2AAR subtype C10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012020.1 RefSeqGene

      Range
      4998..8876
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_545

    mRNA and Protein(s)

    1. NM_000681.4 → NP_000672.3  alpha-2A adrenergic receptor

      See identical proteins and their annotated locations for NP_000672.3

      Status: REVIEWED

      Source sequence(s)
      AF284095, AL158163, BM682651
      Consensus CDS
      CCDS7569.2
      UniProtKB/Swiss-Prot
      B0LPF6, P08913, Q2I8G2, Q2XN99, Q86TH8, Q9BZK1
      Related
      ENSP00000280155.2, ENST00000280155.4
      Conserved Domains (2) summary
      PHA03307
      Location:244 → 389
      PHA03307; transcriptional regulator ICP4; Provisional
      cd15322
      Location:49 → 452
      7tmA_alpha2A_AR; alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      111077029..111080907
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      111960874..111964752
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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