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    HSP90AA1 heat shock protein 90 alpha family class A member 1 [ Homo sapiens (human) ]

    Gene ID: 3320, updated on 27-Dec-2024

    Summary

    Official Symbol
    HSP90AA1provided by HGNC
    Official Full Name
    heat shock protein 90 alpha family class A member 1provided by HGNC
    Primary source
    HGNC:HGNC:5253
    See related
    Ensembl:ENSG00000080824 MIM:140571; AllianceGenome:HGNC:5253
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EL52; HSPN; LAP2; HSP86; HSPC1; HSPCA; Hsp89; Hsp90; LAP-2; HSP89A; HSP90A; HSP90N; Hsp103; HSPCAL1; HSPCAL4; HEL-S-65p
    Summary
    The protein encoded by this gene is an inducible molecular chaperone that functions as a homodimer. The encoded protein aids in the proper folding of specific target proteins by use of an ATPase activity that is modulated by co-chaperones. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
    Expression
    Ubiquitous expression in brain (RPKM 360.6), testis (RPKM 312.5) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See HSP90AA1 in Genome Data Viewer
    Location:
    14q32.31
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (102080742..102139749, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (96316329..96375332, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (102547079..102606086, complement)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene dynein cytoplasmic 1 heavy chain 1 Neighboring gene uncharacterized LOC107984661 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:102515797-102516781 Neighboring gene Sharpr-MPRA regulatory region 9666 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:102522673-102523378 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:102523379-102524082 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:102530418-102531305 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr14:102550057-102551256 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6108 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6109 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6107 Neighboring gene RNA, 7SL, cytoplasmic 472, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6110 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:102605474-102605669 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9065 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9066 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:102622168-102623084 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:102623085-102624001 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:102625184-102625684 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr14:102638165-102639150 Neighboring gene WD repeat domain 20 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:102650679-102651180 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:102651181-102651680 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6111 Neighboring gene uncharacterized LOC105370677 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:102697452-102697952 Neighboring gene MOK protein kinase Neighboring gene MED14-independent group 3 enhancer GRCh37_chr14:102745661-102746860 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:102771382-102771904

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (42 hits/1282 screens)

    EBI GWAS Catalog

    Description
    A genome-wide association study of behavioral disinhibition.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Gag-Pol gag-pol HSP90 is incorporated into HIV-1 GagPol virus-like particles PubMed
    Nef nef Microvesicles, which contaminate purified HIV-1 inocula due to similar size and density, contain viral protein Nef and cellular proteins HSP90alpha and HSP90beta that are capable of potent stimulation of dendritic cells maturation and ICAM-1 expression PubMed
    Pr55(Gag) gag HSP90 is incorporated into HIV-1 Gag virus-like particles PubMed
    Tat tat Hyperthermia (39.5C) increases expression of HSP90 protein in CD4+ T cells, which enhances HIV-1 Tat-mediated transactivation of the LTR. Hyperthermia also increases single-cycle HIV-1 infection PubMed
    tat HIV-1 Tat downregulates the expression of HSP90 in CD4+ T cells, which may contribute to the impairment of hTERT stability and activation in Tat exposed cells PubMed
    tat Hsp90 chaperone activity is required for HIV-1 Tat transport through the endosome membrane PubMed
    tat Upregulation of actin, heat shock protein 90 and mitochondrial single-stranded DNA binding protein, and downregulation of lactate dehydrogenase are identified in human astrocytes expressing Tat PubMed
    tat Hsp70 and Hsp90 and Cdc37 regulate the stabilization and folding of CDK9 as well as the assembly of an active CDK9/cyclin T1 complex responsible for P-TEFb-mediated HIV-1 Tat transactivation PubMed
    Vif vif HIV-1 Vif interacts with HSP90AA1; interaction predicted to be relevant in protein folding and/or macromolecular structure assembly PubMed
    retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human heat shock protein 90kDa alpha (cytosolic), class A member 1 (HSP90AA1) at amino acid residues 473-474 and 491-492 by the HIV-1 protease PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • FLJ31884

    Gene Ontology Provided by GOA

    Items 1 - 25 of 33
    Function Evidence Code Pubs
    enables ATP binding  
    enables ATP binding PubMed 
    enables ATP hydrolysis activity  
    enables ATP hydrolysis activity PubMed 
    enables ATP hydrolysis activity  
    enables ATP-dependent protein folding chaperone  
    enables CTP binding  
    enables DNA polymerase binding PubMed 
    enables GTP binding  
    enables GTPase binding PubMed 
    enables MHC class II protein complex binding PubMed 
    enables RNA binding PubMed 
    enables Rho GDP-dissociation inhibitor binding  
    enables TPR domain binding PubMed 
    enables TPR domain binding PubMed 
    enables UTP binding  
    enables dATP binding  
    enables disordered domain specific binding PubMed 
    enables histone deacetylase binding PubMed 
    enables identical protein binding PubMed 
    enables identical protein binding PubMed 
    enables mRNA binding  
    enables nitric-oxide synthase regulator activity PubMed 
    enables protein binding PubMed 
    enables protein homodimerization activity PubMed 
    enables protein phosphatase binding  
    enables protein tyrosine kinase binding PubMed 
    enables scaffold protein binding PubMed 
    enables sulfonylurea receptor binding  
    enables tau protein binding PubMed 
    enables transmembrane transporter binding  
    enables ubiquitin protein ligase binding PubMed 
    enables unfolded protein binding  
    Items 1 - 25 of 33
    Items 1 - 25 of 41
    Process Evidence Code Pubs
    involved_in activation of innate immune response PubMed 
    involved_in cardiac muscle cell apoptotic process  
    involved_in cellular response to heat  
    involved_in cellular response to virus PubMed 
    involved_in chaperone-mediated autophagy PubMed 
    involved_in chaperone-mediated protein complex assembly PubMed 
    involved_in mitochondrial transport PubMed 
    involved_in neurofibrillary tangle assembly PubMed 
    involved_in neuron migration  
    involved_in positive regulation of cardiac muscle contraction  
    involved_in positive regulation of cell size  
    involved_in positive regulation of defense response to virus by host PubMed 
    involved_in positive regulation of interferon-beta production PubMed 
    involved_in positive regulation of lamellipodium assembly  
    involved_in positive regulation of nitric oxide biosynthetic process  
    involved_in positive regulation of protein catabolic process PubMed 
    involved_in positive regulation of protein import into nucleus  
    involved_in positive regulation of protein polymerization PubMed 
    involved_in positive regulation of telomere maintenance via telomerase PubMed 
    involved_in protein folding  
    involved_in protein insertion into mitochondrial outer membrane PubMed 
    involved_in protein refolding PubMed 
    involved_in protein stabilization  
    involved_in protein stabilization PubMed 
    involved_in protein unfolding PubMed 
    involved_in regulation of apoptotic process PubMed 
    involved_in regulation of postsynaptic membrane neurotransmitter receptor levels  
    involved_in regulation of protein localization  
    involved_in regulation of protein ubiquitination PubMed 
    involved_in regulation of protein-containing complex assembly PubMed 
    involved_in response to antibiotic  
    involved_in response to cocaine  
    involved_in response to cold  
    involved_in response to estrogen  
    involved_in response to heat  
    involved_in response to salt stress  
    involved_in response to unfolded protein PubMed 
    involved_in response to xenobiotic stimulus  
    involved_in skeletal muscle contraction  
    involved_in telomerase holoenzyme complex assembly PubMed 
    acts_upstream_of_positive_effect telomere maintenance via telomerase PubMed 
    Items 1 - 25 of 41
    Items 1 - 20 of 38
    Component Evidence Code Pubs
    located_in apical plasma membrane  
    located_in axonal growth cone  
    located_in basolateral plasma membrane  
    located_in brush border membrane  
    located_in cell surface  
    located_in collagen-containing extracellular matrix  
    located_in cytoplasm PubMed 
    located_in cytoplasm  
    is_active_in cytosol  
    located_in cytosol  
    located_in cytosol PubMed 
    located_in cytosol  
    located_in dendritic growth cone  
    located_in endocytic vesicle lumen  
    located_in extracellular exosome PubMed 
    located_in extracellular region  
    located_in ficolin-1-rich granule lumen  
    located_in lysosomal lumen PubMed 
    located_in melanosome  
    located_in membrane PubMed 
    located_in mitochondrion PubMed 
    is_active_in myelin sheath  
    is_active_in neuronal cell body  
    located_in neuronal cell body  
    located_in nucleoplasm  
    located_in nucleoplasm  
    located_in nucleus PubMed 
    is_active_in nucleus  
    located_in nucleus  
    is_active_in perinuclear region of cytoplasm  
    located_in perinuclear region of cytoplasm  
    is_active_in plasma membrane  
    located_in plasma membrane  
    part_of protein-containing complex  
    part_of protein-containing complex PubMed 
    located_in secretory granule lumen  
    located_in sperm mitochondrial sheath  
    located_in sperm plasma membrane  
    Items 1 - 20 of 38

    General protein information

    Preferred Names
    heat shock protein HSP 90-alpha
    Names
    HSP 86
    LPS-associated protein 2
    epididymis luminal secretory protein 52
    epididymis secretory sperm binding protein Li 65p
    heat shock 86 kDa
    heat shock 90kD protein 1, alpha
    heat shock 90kD protein 1, alpha-like 4
    heat shock 90kD protein, alpha-like 4
    heat shock 90kDa protein 1, alpha
    heat shock protein 90kDa alpha (cytosolic), class A member 1
    heat shock protein 90kDa alpha family class A member 1
    heat shock protein family C member 1
    lipopolysaccharide-associated protein 2
    renal carcinoma antigen NY-REN-38
    NP_001017963.2
    NP_005339.3
    XP_011535020.1
    XP_054231954.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001017963.3 → NP_001017963.2  heat shock protein HSP 90-alpha isoform 1

      See identical proteins and their annotated locations for NP_001017963.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AI250920, AJ890083, BX248761, DA237149
      Consensus CDS
      CCDS32160.1
      UniProtKB/Swiss-Prot
      P07900
      UniProtKB/TrEMBL
      Q86SX1
      Related
      ENSP00000335153.7, ENST00000334701.11
      Conserved Domains (3) summary
      smart00387
      Location:162 → 313
      HATPase_c; Histidine kinase-like ATPases
      PTZ00272
      Location:140 → 854
      PTZ00272; heat shock protein 83 kDa (Hsp83); Provisional
      pfam00183
      Location:318 → 844
      HSP90; Hsp90 protein
    2. NM_005348.4 → NP_005339.3  heat shock protein HSP 90-alpha isoform 2

      See identical proteins and their annotated locations for NP_005339.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AI250920, AJ890083, DC303876
      Consensus CDS
      CCDS9967.1
      UniProtKB/Swiss-Prot
      A8K500, B3KPJ9, P07900, Q2PP14, Q5CAQ6, Q5CAQ7, Q9BVQ5
      UniProtKB/TrEMBL
      K9JA46, Q8TBA7
      Related
      ENSP00000216281.8, ENST00000216281.13
      Conserved Domains (1) summary
      PTZ00272
      Location:18 → 732
      PTZ00272; heat shock protein 83 kDa (Hsp83); Provisional

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      102080742..102139749 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011536718.3 → XP_011535020.1  heat shock protein HSP 90-alpha isoform X1

      Conserved Domains (3) summary
      smart00387
      Location:161 → 312
      HATPase_c; Histidine kinase-like ATPases
      PTZ00272
      Location:139 → 853
      PTZ00272; heat shock protein 83 kDa (Hsp83); Provisional
      pfam00183
      Location:317 → 843
      HSP90; Hsp90 protein

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      96316329..96375332 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054375979.1 → XP_054231954.1  heat shock protein HSP 90-alpha isoform X1

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