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    dgt1 dim gamma-tubulin 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43529, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dgt1provided by FlyBase
    Official Full Name
    dim gamma-tubulin 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0039710
    Locus tag
    Dmel_CG18041
    See related
    AllianceGenome:FB:FBgn0039710
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG18041; Dgt1; Dmel\CG18041; NSL2
    Summary
    Involved in positive regulation of transcription by RNA polymerase II. Located in nucleus. Part of NSL complex. Is expressed in organism. Orthologous to human KANSL2 (KAT8 regulatory NSL complex subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See dgt1 in Genome Data Viewer
    Location:
    99C4-99C4; 3-99 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (29854695..29857491, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (25680417..25683213, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Autophagy-related 16 Neighboring gene uncharacterized protein Neighboring gene Protamine-like 99C Neighboring gene Cadherin 99C Neighboring gene uncharacterized protein Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The NSL complex regulates housekeeping genes in Drosophila. Lam KC, et al. PLoS Genet, 2012. PMID 22723752, Free PMC Article
    2. An epigenetic regulator emerges as microtubule minus-end binding and stabilizing factor in mitosis. Meunier S, et al. Nat Commun, 2015 Aug 5. PMID 26243146, Free PMC Article
    3. The effector caspases drICE and dcp-1 have partially overlapping functions in the apoptotic pathway in Drosophila. Xu D, et al. Cell Death Differ, 2006 Oct. PMID 16645642, Free PMC Article
    4. The NSL complex-mediated nucleosome landscape is required to maintain transcription fidelity and suppression of transcription noise. Lam KC, et al. Genes Dev, 2019 Apr 1. PMID 30819819, Free PMC Article
    5. The activation potential of MOF is constrained for dosage compensation. Prestel M, et al. Mol Cell, 2010 Jun 25. PMID 20620953

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of NSL complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of NSL complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of histone acetyltransferase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dim gamma-tubulin 1
    Names
    CG18041-PA
    CG18041-PB
    CG18041-PC
    dgt1-PA
    dgt1-PB
    dgt1-PC
    non-specific lethal 2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      29854695..29857491 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143480.4 → NP_651737.1  dim gamma-tubulin 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651737.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95RT2, Q9VAF4
      Related
      FBpp0084893
      Conserved Domains (1) summary
      pfam13891
      Location:349 → 411
      zf-C3Hc3H; Potential DNA-binding domain

    2. NM_001300666.1 → NP_001287595.1  dim gamma-tubulin 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287595.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LHU7
      Conserved Domains (1) summary
      pfam13891
      Location:354 → 411
      zf-C3Hc3H; Potential DNA-binding domain

    3. NM_001276154.1 → NP_001263083.1  dim gamma-tubulin 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001263083.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KHH6
      Conserved Domains (1) summary
      pfam13891
      Location:349 → 411
      zf-C3Hc3H; Potential DNA-binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KHH6 A0A0B4KHH6
    A0A0B4LHU7 A0A0B4LHU7
    Q9VAF4 Q9VAF4

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