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    PEX22 ubiquitin-protein transferase activating protein PEX22 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851244, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PEX22
    Official Full Name
    ubiquitin-protein transferase activating protein PEX22
    Primary source
    SGD:S000000051
    Locus tag
    YAL055W
    See related
    AllianceGenome:SGD:S000000051; FungiDB:YAL055W; VEuPathDB:YAL055W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    YAF5
    Summary
    Enables ubiquitin-protein transferase activator activity. Involved in positive regulation of protein autoubiquitination and protein import into peroxisome matrix, receptor recycling. Located in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See PEX22 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_001133.9 (42177..42719)

    Chromosome I - NC_001133.9Genomic Context describing neighboring genes Neighboring gene calnexin Neighboring gene Gpb2p Neighboring gene acetate--CoA ligase 1 Neighboring gene flavin adenine dinucleotide transporter FLC2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001133.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Pex22p of Pichia pastoris, essential for peroxisomal matrix protein import, anchors the ubiquitin-conjugating enzyme, Pex4p, on the peroxisomal membrane. Koller A, et al. J Cell Biol, 1999 Jul 12. PMID 10402463, Free PMC Article
    2. Mutation in the peroxin-coding gene PEX22 contributing to high malate production in Saccharomyces cerevisiae. Negoro H, et al. J Biosci Bioeng, 2018 Feb. PMID 28919252
    3. A disulphide bond in the E2 enzyme Pex4p modulates ubiquitin-conjugating activity. Williams C, et al. Sci Rep, 2013. PMID 23896733, Free PMC Article
    4. Ubiquitination of the peroxisomal import receptor Pex5p is required for its recycling. Platta HW, et al. J Cell Biol, 2007 Apr 23. PMID 17452527, Free PMC Article
    5. The N-domain of Pex22p can functionally replace the Pex3p N-domain in targeting and peroxisome formation. Halbach A, et al. J Biol Chem, 2009 Feb 6. PMID 19017643

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. mutation, causing Pex22p dysfunction, was sufficient to confer increased malate productivity and dimethyl succinate sensitivity to yeast cells
      Title: Mutation in the peroxin-coding gene PEX22 contributing to high malate production in Saccharomyces cerevisiae.
    2. The cytosolic domain of Pex22p stimulates the Pex4p-dependent ubiquitination of the PTS1-receptor (Pex5).
      Title: The cytosolic domain of Pex22p stimulates the Pex4p-dependent ubiquitination of the PTS1-receptor.
    3. The Pex4p:Pex22p assembly, and not Pex4p alone, functions as the E2 enzyme required for Pex5p ubiquitination. This is a novel mechanism of E2 enzyme regulation.
      Title: Insights into ubiquitin-conjugating enzyme/ co-activator interactions from the structure of the Pex4p:Pex22p complex.
    4. The N-domain of Pex22p can functionally replace the Pex3p N-domain in targeting and peroxisome formation.
      Title: The N-domain of Pex22p can functionally replace the Pex3p N-domain in targeting and peroxisome formation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ubiquitin-protein transferase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in peroxisome organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of protein autoubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein import into peroxisome matrix, receptor recycling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in peroxisomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in peroxisome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin-protein transferase activating protein PEX22
    NP_009346.1
    • Putative peroxisomal membrane protein; required for import of peroxisomal proteins; functionally complements a Pichia pastoris pex22 mutation

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001133.9 Reference assembly

      Range
      42177..42719
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178198.1 → NP_009346.1  TPA: ubiquitin-protein transferase activating protein PEX22 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009346.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VPG3, P39718
      UniProtKB/TrEMBL
      G2W8H7
      Conserved Domains (1) summary
      pfam12827
      Location:51 → 167
      Peroxin-22; Peroxisomal biogenesis protein family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P39718.1

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