TRA1 histone acetyltransferase TRA1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: TRA1
Official Full Name: histone acetyltransferase TRA1
Primary source: SGD:S000001141
Locus tag: YHR099W
See related: AllianceGenome:SGD:S000001141; FungiDB:YHR099W; VEuPathDB:YHR099W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Contributes to histone acetyltransferase activity. Involved in DNA repair and positive regulation of transcription by RNA polymerase II. Located in nucleus. Part of NuA4 histone acetyltransferase complex; SAGA complex; and SLIK (SAGA-like) complex. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 75. Orthologous to human TRRAP (transformation/transcription domain associated protein). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See TRA1 in Genome Data Viewer

Location:: chromosome: VIII

Exon count:: 1

Sequence:: Chromosome: VIII; NC_001140.6 (302761..313995)

Chromosome VIII - NC_001140.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tra1 controls the transcriptional landscape of the aging cell.
Title: Tra1 controls the transcriptional landscape of the aging cell.
Structure of the NuA4 acetyltransferase complex bound to the nucleosome.
Title: Structure of the NuA4 acetyltransferase complex bound to the nucleosome.
Tra1 contributes to the overall integrity of NuA4, whereas, within SAGA, it specifically controls the incorporation of the de-ubiquitination module (DUB), as part of an ordered assembly pathway.
Title: Chaperone-mediated ordered assembly of the SAGA and NuA4 transcription co-activator complexes in yeast.
Tra1 allows a single activator to recruit both SAGA and NuA4, and functions as a passive bridge between activators and coactivators. [review]
Title: Share and share alike: the role of Tra1 from the SAGA and NuA4 coactivator complexes.
The molecular structure of the SAGA and NuA4 coactivator subunit Tra1 has been reported.
Title: Cryo-EM structure of the SAGA and NuA4 coactivator subunit Tra1 at 3.7 angstrom resolution.
Tra1 recruitment at Gcn4-dependent and Rap1-dependent promoters requires the same regions of Tra1, and separate regions of Tra1 contribute to the HAT activity and stability of the SAGA and NuA4 HAT modules.
Title: Domains of Tra1 important for activator recruitment and transcription coactivator functions of SAGA and NuA4 complexes.
findings demonstrate the importance of the FATC domain in the structure/function of Tra1
Title: Mutational analysis of the C-terminal FATC domain of Saccharomyces cerevisiae Tra1.
Genetic interactions have been identified which link Tra1 protein to gene expression, mitochondrial function, and membrane sorting/protein trafficking.
Title: Systematic genetic array analysis links the Saccharomyces cerevisiae SAGA/SLIK and NuA4 component Tra1 to multiple cellular processes.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
contributes_to histone acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA repair	IDA Inferred from Direct Assay more info	PubMed
involved_in DNA repair-dependent chromatin remodeling	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to stress	IEA Inferred from Electronic Annotation more info
involved_in chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of NuA4 histone acetyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of NuA4 histone acetyltransferase complex	IDA Inferred from Direct Assay more info	PubMed
part_of SAGA complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SAGA complex	IDA Inferred from Direct Assay more info	PubMed
part_of SLIK (SAGA-like) complex	IDA Inferred from Direct Assay more info	PubMed
part_of TTT Hsp90 cochaperone complex	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: histone acetyltransferase TRA1

NP_011967.1

Subunit of SAGA and NuA4 histone acetyltransferase complexes; subunit of the TTT Hsp90 cochaperone complex that is involved in chromatin remodeling and telomeric chromatin regulation; interacts with acidic activators (e.g., Gal4p) which leads to transcription activation; similar to human TRRAP, which is a cofactor for c-Myc mediated oncogenic transformation

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001140.6 Reference assembly

Range

302761..313995

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179229.1 → NP_011967.1 TPA: histone acetyltransferase TRA1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_011967.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D3DL49, P38811

UniProtKB/TrEMBL

A6ZT07, C7GLY6, N1P137

Conserved Domains (1) summary

COG5032
Location:1232 → 3744

TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]