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    ATP2A3 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 [ Homo sapiens (human) ]

    Gene ID: 489, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ATP2A3provided by HGNC
    Official Full Name
    ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3provided by HGNC
    Primary source
    HGNC:HGNC:813
    See related
    Ensembl:ENSG00000074370 MIM:601929; AllianceGenome:HGNC:813
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SERCA3
    Summary
    This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in calcium sequestration associated with muscular excitation and contraction. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in lymph node (RPKM 38.6), stomach (RPKM 37.7) and 18 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ATP2A3 in Genome Data Viewer
    Location:
    17p13.2
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (3923873..3964437, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (3813121..3853682, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (3827167..3867731, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:3771089-3771590 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:3771591-3772090 Neighboring gene Sharpr-MPRA regulatory region 11291 Neighboring gene calcium/calmodulin dependent protein kinase kinase 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:3791367-3791886 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:3791887-3792408 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8022 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8023 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8024 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:3807108-3807786 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11522 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11523 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11524 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11525 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11526 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11527 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11528 Neighboring gene purinergic receptor P2X 1 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr17:3831158-3832357 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:3833185-3834129 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:3844399-3844898 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8025 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:3856267-3857115 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:3860613-3861517 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8026 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8027 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8028 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8029 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11529 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:3879079-3879915 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:3879916-3880751 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:3885316-3886231 Neighboring gene long intergenic non-protein coding RNA 1975 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11530 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8030 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8031 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:3910389-3911356 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11531 Neighboring gene zinc finger ZZ-type and EF-hand domain containing 1 Neighboring gene RNA, 5S ribosomal pseudogene 434

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. ATP2A3 gene is involved in cancer susceptibility. Korosec B, et al. Cancer Genet Cytogenet, 2009 Jan 15. PMID 19100511
    2. Induction of cell differentiation activates transcription of the Sarco/Endoplasmic Reticulum calcium-ATPase 3 gene (ATP2A3) in gastric and colon cancer cells. Flores-Peredo L, et al. Mol Carcinog, 2017 Feb. PMID 27433831
    3. Loss of endoplasmic reticulum calcium pump expression in choroid plexus tumours. Ait-Ghezali L, et al. Neuropathol Appl Neurobiol, 2014 Oct. PMID 24224513
    4. Aberrant SERCA3 expression during the colorectal adenoma-adenocarcinoma sequence. Gou WF, et al. Oncol Rep, 2014 Jan. PMID 24213720
    5. Assessment and characterization of Ca2+-ATPase expression in selected isolates and clones of Plasmodium falciparum. Bolaji OM, et al. Niger J Physiol Sci, 2012 Jun 7. PMID 23235306

    See all (74) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Sarco/endoplasmic reticulum calcium ATPase 3 (SERCA3) expression in gastrointestinal stromal tumours.
      Title: Sarco/endoplasmic reticulum calcium ATPase 3 (SERCA3) expression in gastrointestinal stromal tumours.
    2. Data show that the nucleotide sequence from -280 to -135 position is an ATP2A3 epigenetic regulatory CpG region. SERCA3 mRNA expression is decreased during gastric and colorectal carcinoma development and tumors with high SERCA3 expression are associated with increased overall survival. These results suggest an essential role for SERCA3 in the regulation of cellular identity and growth, through cellular Ca2+ management.
      Title: Epigenetic regulation of the human ATP2A3 gene promoter in gastric and colon cancer cell lines.
    3. This study demonstrates that ATP2A3 might be one of the potential targets for salinomycin, which can inhibit Ca(2+) release and trigger ER stress to exert anti-cancer effects.
      Title: Salinomycin triggers endoplasmic reticulum stress through ATP2A3 upregulation in PC-3 cells.
    4. Sp1, Sp3, and Klf-4 transcription factors bind to ATP2A3 proximal promoter elements and regulate basal gene expression. The study showed that these factors participated in the increase of ATP2A3 expression during cancer cell differentiation.
      Title: Induction of cell differentiation activates transcription of the Sarco/Endoplasmic Reticulum calcium-ATPase 3 gene (ATP2A3) in gastric and colon cancer cells.
    5. Together, these data provide evidence for the interaction of Bcl-2 with SERCA3b in vitro and in cell culture, and for Bcl-2-dependent conformational and functional changes of SERCA3b.
      Title: Inhibition and conformational change of SERCA3b induced by Bcl-2.
    6. ATP2A3 methylation was not altered between patients with type 2 diabetes and healthy men. Moreover, a glucose challenge did not alter ATP2A3 methylation.
      Title: Insulin and Glucose Alter Death-Associated Protein Kinase 3 (DAPK3) DNA Methylation in Human Skeletal Muscle.
    7. we make a comprehensive analysis of the current knowledge of the role of the SERCA pumps in the pathophysiology of insulin-dependent diabetes mellitus type 1 (TIDM) and type 2 (T2DM) in the heart and beta-cells in the pancreas
      Title: Regulation of SERCA pumps expression in diabetes.
    8. Normal choroid plexus epithelial cells express SERCA3 abundantly, SERCA3 expression is strongly decreased in papillomas, and is absent in choroid plexus carcinoma, while expression in hyperplastic epithelium is high, similarly to normal epithelium.
      Title: Loss of endoplasmic reticulum calcium pump expression in choroid plexus tumours.
    9. aberrant SERCA3 expression is closely linked to the adenoma-adenocarcinoma sequence and progression of colorectal carcinomas.
      Title: Aberrant SERCA3 expression during the colorectal adenoma-adenocarcinoma sequence.
    10. The Ca2+-ATPase activity in cloned Plasmodiuim falciparum strain D6 protein is higher than in cloned strain W2 protein. The Ca2+-ATPase activity in isolates from malaria patients varied widely.
      Title: Assessment and characterization of Ca2+-ATPase expression in selected isolates and clones of Plasmodium falciparum.
    Submit: New GeneRIF Correction See all GeneRIFs (32)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp160, precursor env HIV-1 Env is identified to have a physical interaction with ATPase, Ca++ transporting, ubiquitous (ATP2A3) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables P-type calcium transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables P-type calcium transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables P-type calcium transporter activity TAS
    Traceable Author Statement
    more info
    		  
    enables calcium ion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calcium-dependent ATPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cysteine-type endopeptidase activator activity involved in apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transmembrane transporter binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in calcium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in calcium ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in calcium ion transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in calcium ion transport from cytosol to endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in intracellular calcium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular calcium ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in monoatomic ion transmembrane transport TAS
    Traceable Author Statement
    more info
    		  
    involved_in negative regulation of receptor binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cardiac conduction TAS
    Traceable Author Statement
    more info
    		  
    involved_in transport across blood-brain barrier NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in organelle membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in platelet dense tubular network membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in sarcoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in sarcoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    sarcoplasmic/endoplasmic reticulum calcium ATPase 3
    Names
    ATPase, Ca(2+)-transporting, ubiquitous
    ATPase, Ca++ transporting, ubiquitous
    SR Ca(2+)-ATPase 3
    adenosine triphosphatase, calcium
    calcium pump 3
    calcium-translocating P-type ATPase
    sarco/endoplasmic reticulum Ca2+ -ATPase
    NP_005164.2
    NP_777613.1
    NP_777614.1
    NP_777615.1
    NP_777616.1
    NP_777617.1
    NP_777618.1
    XP_011522183.1
    XP_011522184.1
    XP_011522186.1
    XP_011522187.1
    XP_011522190.1
    XP_011522191.1
    XP_011522194.1
    XP_047292106.1
    XP_047292107.1
    XP_047292108.1
    XP_047292109.1
    XP_054172247.1
    XP_054172248.1
    XP_054172249.1
    XP_054172250.1
    XP_054172251.1
    XP_054172252.1
    XP_054172253.1
    XP_054172254.1
    XP_054172255.1
    XP_054172256.1
    XP_054172257.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029041.1 RefSeqGene

      Range
      5006..45570
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_005173.4 → NP_005164.2  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform a

      See identical proteins and their annotated locations for NP_005164.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform a.
      Source sequence(s)
      AA643105, AC005940, AK292716, BC035729, Z69881
      Consensus CDS
      CCDS45579.1
      UniProtKB/Swiss-Prot
      A8MZG0, D3DTJ8, O60900, O60901, O75501, O75502, Q16115, Q6JHX1, Q8TEX5, Q8TEX6, Q93084
      UniProtKB/TrEMBL
      A8K9K1
      Related
      ENSP00000380234.3, ENST00000397041.8
      Conserved Domains (1) summary
      cd02083
      Location:5 → 989
      P-type_ATPase_SERCA; sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3

    2. NM_174953.3 → NP_777613.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform e

      See identical proteins and their annotated locations for NP_777613.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) includes two additional exons in the 3' coding region but maintains the reading frame, compared to variant 1. Variant 5 encodes isoform e, which is longer than isoform a.
      Source sequence(s)
      AA643105, AC005940, AF458229, AK292716, BC035729, Z69881
      Consensus CDS
      CCDS11042.1
      UniProtKB/TrEMBL
      A8K9K1
      Related
      ENSP00000353072.3, ENST00000359983.7
      Conserved Domains (6) summary
      TIGR01116
      Location:53 → 989
      ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase
      pfam00122
      Location:92 → 340
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:784 → 987
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam00690
      Location:4 → 72
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam12710
      Location:604 → 712
      HAD; haloacid dehalogenase-like hydrolase
      pfam13246
      Location:419 → 528
      Cation_ATPase; Cation transport ATPase (P-type)

    3. NM_174954.3 → NP_777614.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform d

      See identical proteins and their annotated locations for NP_777614.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) includes two additional exons in the 3' coding region resulting in a frameshift, compared to variant 1. Variant 4 encodes isoform d, which is longer and has a distinct C-terminus compared to isoform a.
      Source sequence(s)
      AA643105, AC005940, AF458228, AK292716, BC035729, Z69881
      UniProtKB/TrEMBL
      A8K9K1
      Conserved Domains (6) summary
      TIGR01116
      Location:53 → 989
      ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase
      pfam00122
      Location:92 → 340
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:784 → 987
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam00690
      Location:4 → 72
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam12710
      Location:604 → 712
      HAD; haloacid dehalogenase-like hydrolase
      pfam13246
      Location:419 → 528
      Cation_ATPase; Cation transport ATPase (P-type)

    4. NM_174955.3 → NP_777615.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform b

      See identical proteins and their annotated locations for NP_777615.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) includes an additional exon in the 3' coding region resulting in a frameshift, compared to variant 1. Variant 2 encodes isoform b, which is longer and has a distinct C-terminus compared to isoform a.
      Source sequence(s)
      AA643105, AC005940, AF458228, AK292716, BC035729, Z69881
      Consensus CDS
      CCDS11041.1
      UniProtKB/TrEMBL
      A8K9K1
      Related
      ENSP00000301387.6, ENST00000352011.7
      Conserved Domains (6) summary
      TIGR01116
      Location:53 → 989
      ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase
      pfam00122
      Location:92 → 340
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:784 → 987
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam00690
      Location:4 → 72
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam12710
      Location:604 → 712
      HAD; haloacid dehalogenase-like hydrolase
      pfam13246
      Location:419 → 528
      Cation_ATPase; Cation transport ATPase (P-type)

    5. NM_174956.3 → NP_777616.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform c

      See identical proteins and their annotated locations for NP_777616.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) includes an additional exon in the 3' coding region resulting in a frameshift, compared to variant 1. Variant 3 encodes isoform c, which is longer and has a distinct C-terminus compared to isoform a.
      Source sequence(s)
      AA643105, AC005940, AF458229, AK292716, BC035729, Z69881
      Consensus CDS
      CCDS42234.1
      UniProtKB/TrEMBL
      A8K9K1
      Related
      ENSP00000312577.7, ENST00000309890.11
      Conserved Domains (6) summary
      TIGR01116
      Location:53 → 989
      ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase
      pfam00122
      Location:92 → 340
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:784 → 987
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam00690
      Location:4 → 72
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam12710
      Location:604 → 712
      HAD; haloacid dehalogenase-like hydrolase
      pfam13246
      Location:419 → 528
      Cation_ATPase; Cation transport ATPase (P-type)

    6. NM_174957.3 → NP_777617.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform f

      See identical proteins and their annotated locations for NP_777617.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) uses an alternate in frame splice site in the 3' coding region, compared to variant 1. Variant 6 encodes isoform f, which is one aa shorter than isoform a.
      Source sequence(s)
      AA643105, AC005940, AF068220, AK292716, BC035729, Z69881
      Consensus CDS
      CCDS45580.1
      UniProtKB/TrEMBL
      A8K9K1
      Related
      ENSP00000380236.3, ENST00000397043.7
      Conserved Domains (6) summary
      TIGR01116
      Location:53 → 989
      ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase
      pfam00122
      Location:92 → 340
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:784 → 987
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam00690
      Location:4 → 72
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam12710
      Location:604 → 712
      HAD; haloacid dehalogenase-like hydrolase
      pfam13246
      Location:419 → 528
      Cation_ATPase; Cation transport ATPase (P-type)

    7. NM_174958.3 → NP_777618.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform c

      See identical proteins and their annotated locations for NP_777618.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) includes an additional exon and uses alternate splices in the 3' coding region resulting in a frameshift, compared to variant 1. Variant 7 encodes isoform c, which is longer and has a distinct C-terminus compared to isoform a.
      Source sequence(s)
      AA643105, AC005940, AF068221, AK292716, BC035729
      Consensus CDS
      CCDS42234.1
      UniProtKB/TrEMBL
      A8K9K1
      Related
      ENSP00000380229.3, ENST00000397035.8
      Conserved Domains (6) summary
      TIGR01116
      Location:53 → 989
      ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase
      pfam00122
      Location:92 → 340
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:784 → 987
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam00690
      Location:4 → 72
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam12710
      Location:604 → 712
      HAD; haloacid dehalogenase-like hydrolase
      pfam13246
      Location:419 → 528
      Cation_ATPase; Cation transport ATPase (P-type)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      3923873..3964437 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047436153.1 → XP_047292109.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X9

      UniProtKB/TrEMBL
      A8K9K1

    2. XM_047436151.1 → XP_047292107.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X6

      UniProtKB/TrEMBL
      A8K9K1

    3. XM_011523885.2 → XP_011522187.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X4

      UniProtKB/TrEMBL
      A8K9K1
      Conserved Domains (6) summary
      TIGR01116
      Location:53 → 989
      ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase
      pfam00122
      Location:92 → 340
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:784 → 987
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam00690
      Location:4 → 72
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam12710
      Location:604 → 712
      HAD; haloacid dehalogenase-like hydrolase
      pfam13246
      Location:419 → 528
      Cation_ATPase; Cation transport ATPase (P-type)

    4. XM_047436150.1 → XP_047292106.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X5

      UniProtKB/TrEMBL
      A8K9K1

    5. XM_047436152.1 → XP_047292108.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X7

      UniProtKB/TrEMBL
      A8K9K1

    6. XM_011523888.3 → XP_011522190.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X7

      UniProtKB/TrEMBL
      A8K9K1
      Conserved Domains (6) summary
      TIGR01116
      Location:53 → 989
      ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase
      pfam00122
      Location:92 → 340
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:784 → 987
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam00690
      Location:4 → 72
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam12710
      Location:604 → 712
      HAD; haloacid dehalogenase-like hydrolase
      pfam13246
      Location:419 → 528
      Cation_ATPase; Cation transport ATPase (P-type)

    7. XM_011523881.3 → XP_011522183.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1

      UniProtKB/TrEMBL
      A8K9K1
      Conserved Domains (6) summary
      TIGR01116
      Location:53 → 989
      ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase
      pfam00122
      Location:92 → 340
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:784 → 987
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam00690
      Location:4 → 72
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam12710
      Location:604 → 712
      HAD; haloacid dehalogenase-like hydrolase
      pfam13246
      Location:419 → 528
      Cation_ATPase; Cation transport ATPase (P-type)

    8. XM_011523882.3 → XP_011522184.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X2

      UniProtKB/TrEMBL
      A8K9K1
      Conserved Domains (6) summary
      TIGR01116
      Location:53 → 989
      ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase
      pfam00122
      Location:92 → 340
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:784 → 987
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam00690
      Location:4 → 72
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam12710
      Location:604 → 712
      HAD; haloacid dehalogenase-like hydrolase
      pfam13246
      Location:419 → 528
      Cation_ATPase; Cation transport ATPase (P-type)

    9. XM_011523884.4 → XP_011522186.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X3

      UniProtKB/TrEMBL
      A8K9K1
      Conserved Domains (6) summary
      TIGR01116
      Location:53 → 989
      ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase
      pfam00122
      Location:92 → 340
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:784 → 987
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam00690
      Location:4 → 72
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam12710
      Location:604 → 712
      HAD; haloacid dehalogenase-like hydrolase
      pfam13246
      Location:419 → 528
      Cation_ATPase; Cation transport ATPase (P-type)

    10. XM_011523889.2 → XP_011522191.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X8

      UniProtKB/TrEMBL
      A8K9K1
      Conserved Domains (6) summary
      TIGR01116
      Location:53 → 989
      ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase
      pfam00122
      Location:92 → 340
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:784 → 987
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam00690
      Location:4 → 72
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam12710
      Location:604 → 712
      HAD; haloacid dehalogenase-like hydrolase
      pfam13246
      Location:419 → 528
      Cation_ATPase; Cation transport ATPase (P-type)

    11. XM_011523892.3 → XP_011522194.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X10

      Conserved Domains (3) summary
      pfam00122
      Location:92 → 340
      E1-E2_ATPase; E1-E2 ATPase
      pfam00690
      Location:4 → 72
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam13246
      Location:419 → 518
      Cation_ATPase; Cation transport ATPase (P-type)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      3813121..3853682 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054316281.1 → XP_054172256.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X9

      UniProtKB/TrEMBL
      A8K9K1

    2. XM_054316277.1 → XP_054172252.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X6

      UniProtKB/TrEMBL
      A8K9K1

    3. XM_054316275.1 → XP_054172250.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X4

      UniProtKB/TrEMBL
      A8K9K1

    4. XM_054316276.1 → XP_054172251.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X5

      UniProtKB/TrEMBL
      A8K9K1

    5. XM_054316279.1 → XP_054172254.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X7

      UniProtKB/TrEMBL
      A8K9K1

    6. XM_054316278.1 → XP_054172253.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X7

      UniProtKB/TrEMBL
      A8K9K1

    7. XM_054316272.1 → XP_054172247.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1

      UniProtKB/TrEMBL
      A8K9K1

    8. XM_054316273.1 → XP_054172248.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X2

      UniProtKB/TrEMBL
      A8K9K1

    9. XM_054316274.1 → XP_054172249.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X3

      UniProtKB/TrEMBL
      A8K9K1

    10. XM_054316280.1 → XP_054172255.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X8

      UniProtKB/TrEMBL
      A8K9K1

    11. XM_054316282.1 → XP_054172257.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X10

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q93084.3 GenPept UniProtKB/Swiss-Prot:Q93084

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