m6pr mannose-6-phosphate receptor (cation dependent) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: m6prprovided by ZNC
Official Full Name: mannose-6-phosphate receptor (cation dependent)provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2285
See related: Ensembl:ENSDARG00000018432 AllianceGenome:ZFIN:ZDB-GENE-040426-2285
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: MPR46; zgc:77757; wu:fj81h11
Summary: Enables D-mannose binding activity and protein domain specific binding activity. Acts upstream of or within protein targeting to lysosome. Located in trans-Golgi network. Is expressed in nervous system; presumptive neural retina; and somite. Orthologous to human M6PR (mannose-6-phosphate receptor, cation dependent). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 16

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	16	NC_007127.7 (17580301..17586804, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	16	NC_007127.6 (17672324..17678827, complement)

Chromosome 16 - NC_007127.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The expression patterns suggest time- and tissue-specific functions for the M6P receptors, with particular evidence for roles in neural development.
Title: Mannose 6-phosphate receptors in an ancient vertebrate, zebrafish.
Analysis of full-length sequences for MPR 46 from zebrafish (Danio rerio) and its functional analysis.
Title: The early vertebrate Danio rerio Mr 46000 mannose-6-phosphate receptor: biochemical and functional characterisation.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables D-mannose binding	IDA Inferred from Direct Assay more info	PubMed
enables protein domain specific binding	IEA Inferred from Electronic Annotation more info
enables protein domain specific binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in protein targeting to lysosome	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein targeting to lysosome	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein targeting to lysosome	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in trans-Golgi network	IBA Inferred from Biological aspect of Ancestor more info
located_in trans-Golgi network	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: cation-dependent mannose-6-phosphate receptor

Names: CD-MPR

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.