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    Tsp3A Tetraspanin 3A [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31244, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tsp3Aprovided by FlyBase
    Official Full Name
    Tetraspanin 3Aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0040334
    Locus tag
    Dmel_CG10742
    See related
    AllianceGenome:FB:FBgn0040334
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BACR7C10.6; CG10742; Dm.Tsp3A; Dmel\CG10742; EG:BACR7C10.6; tsp3A
    Summary
    Involved in intracellular protein transport and positive regulation of Notch signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to several human genes including TSPAN33 (tetraspanin 33). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Tsp3A in Genome Data Viewer
    Location:
    3A7-3A7; 1-1 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (2617758..2619738, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (2511791..2513771, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Zeste-white 10 Neighboring gene SET and MYND domain containing, class 3 Neighboring gene eukaryotic translation initiation factor 3 subunit g1 Neighboring gene seipin Neighboring gene Phosphatidylinositol 4-kinase III alpha Neighboring gene brivido-3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Phenotypic suppression of the Drosophila mitochondrial disease-like mutant tko(25t) by duplication of the mutant gene in its natural chromosomal context. Kemppainen E, et al. Mitochondrion, 2009 Sep. PMID 19616644
    2. Structure of the tetraspanin main extracellular domain. A partially conserved fold with a structurally variable domain insertion. Seigneuret M, et al. J Biol Chem, 2001 Oct 26. PMID 11483611
    3. Genome-Wide Screen for New Components of the Drosophila melanogaster Torso Receptor Tyrosine Kinase Pathway. Johns AR, et al. G3 (Bethesda), 2018 Mar 2. PMID 29363515, Free PMC Article
    4. Identification of critical host mitochondrion-associated genes during Ehrlichia chaffeensis infections. Von Ohlen T, et al. Infect Immun, 2012 Oct. PMID 22851751, Free PMC Article
    5. Polarized sorting of Patched enables cytoneme-mediated Hedgehog reception in the Drosophila wing disc. González-Méndez L, et al. EMBO J, 2020 Jun 2. PMID 32311148, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular protein transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of Notch signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tetraspanin 3A
    Names
    CG10742-PA
    CG10742-PB
    Tsp3A-PA
    Tsp3A-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      2617758..2619738 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001258575.1 → NP_001245504.1  tetraspanin 3A, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245504.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U1L0, Q9W4X6
      Conserved Domains (2) summary
      cd03158
      Location:144 → 267
      penumbra_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), penumbra_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
      pfam00335
      Location:42 → 295
      Tetraspannin; Tetraspanin family

    2. NM_080315.3 → NP_525054.2  tetraspanin 3A, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_525054.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U1L0, Q9W4X6
      Related
      FBpp0070429
      Conserved Domains (2) summary
      cd03158
      Location:144 → 267
      penumbra_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), penumbra_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
      pfam00335
      Location:42 → 295
      Tetraspannin; Tetraspanin family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NB16 Q9NB16
    Q9U1L0 Q9U1L0
    Q9W4X6 Q9W4X6

    Gene LinkOut

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