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    Eif4b eukaryotic translation initiation factor 4B [ Mus musculus (house mouse) ]

    Gene ID: 75705, updated on 27-Dec-2024

    Summary

    Official Symbol
    Eif4bprovided by MGI
    Official Full Name
    eukaryotic translation initiation factor 4Bprovided by MGI
    Primary source
    MGI:MGI:95304
    See related
    Ensembl:ENSMUSG00000058655 AllianceGenome:MGI:95304
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Eif4a2; 2310046H11Rik
    Summary
    Predicted to enable RNA strand annealing activity; RNA strand-exchange activity; and ribosomal small subunit binding activity. Predicted to be involved in eukaryotic translation initiation factor 4F complex assembly and formation of translation preinitiation complex. Predicted to be located in cytosol; dendrite; and neuronal cell body. Orthologous to human EIF4B (eukaryotic translation initiation factor 4B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 66.8), placenta adult (RPKM 58.0) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Eif4b in Genome Data Viewer
    Location:
    15 F2; 15 57.26 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (101982208..102005608)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (102073773..102097173)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene keratin 18 Neighboring gene predicted gene, 41405 Neighboring gene STARR-seq mESC enhancer starr_39815 Neighboring gene predicted gene, 53915 Neighboring gene tensin 2 Neighboring gene SPRY domain containing 3 Neighboring gene STARR-positive B cell enhancer ABC_E482

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding  
    enables RNA strand annealing activity  
    enables RNA strand-exchange activity  
    enables ribosomal small subunit binding  
    enables translation initiation factor activity  
    Component Evidence Code Pubs
    located_in cytosol  
    located_in cytosol  
    located_in dendrite  
    located_in neuronal cell body  

    General protein information

    Preferred Names
    eukaryotic translation initiation factor 4B
    Names
    eIF-4B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145625.3NP_663600.2  eukaryotic translation initiation factor 4B

      See identical proteins and their annotated locations for NP_663600.2

      Status: VALIDATED

      Source sequence(s)
      AK045250, CD563487, CO043713
      Consensus CDS
      CCDS49737.1
      UniProtKB/Swiss-Prot
      Q3TD64, Q8BGD9
      UniProtKB/TrEMBL
      Q3TSY9, Q3UGC0
      Related
      ENSMUSP00000127774.2, ENSMUST00000169681.3
      Conserved Domains (3) summary
      COG0724
      Location:83256
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12402
      Location:95171
      RRM_eIF4B; RNA recognition motif in eukaryotic translation initiation factor 4B (eIF-4B) and similar proteins
      pfam08648
      Location:225290
      DUF1777; Protein of unknown function (DUF1777)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      101982208..102005608
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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