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    rodZ cytoskeleton protein RodZ [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946992, updated on 17-Dec-2024

    Summary

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    Official Symbol
    rodZ
    Official Full Name
    cytoskeleton protein RodZ
    Primary source
    ECOCYC:EG10015
    Locus tag
    b2516
    See related
    ASAP:ABE-0008283
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2512; yfgA
    Summary
    RodZ is responsible for maintaining the rod shape of the Escherichia coli cell and is specifically involved in regulating the length of the long axis of the cell. [More information is available at EcoCyc: EG10015].
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    Genomic context

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    Sequence:
    NC_000913.3 (2641831..2642844, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (flavodoxin) Neighboring gene 23S rRNA m(2)A2503 methyltransferase/tRNA m(2)A37 methyltransferase Neighboring gene nucleoside diphosphate kinase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic mechanism regulating bacterial cell shape and metabolism. Shiomi D, et al. Commun Integr Biol, 2009 May. PMID 19641734, Free PMC Article
    2. Bacterial actin MreB assembles in complex with cell shape protein RodZ. van den Ent F, et al. EMBO J, 2010 Mar 17. PMID 20168300, Free PMC Article
    3. Characterization of rodZ mutants: RodZ is not absolutely required for the cell shape and motility. Niba ET, et al. FEMS Microbiol Lett, 2010 Aug 1. PMID 20528937
    4. RodZ, a new player in bacterial cell morphogenesis. Gerdes K. EMBO J, 2009 Feb 4. PMID 19194484, Free PMC Article
    5. The periplasmic disordered domain of RodZ promotes its self-interaction in Escherichia coli. Ikebe R, et al. Genes Cells, 2018 Apr. PMID 29480545

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RodZ functions to regulate MreB assembly during cell elongation and facilitates the formation of the Z ring during cell division in E. coli.
      Title: Division-site localization of RodZ is required for efficient Z ring formation in Escherichia coli.
    2. the membrane protein RodZ regulates the biophysical properties of MreB and alters the spatial organization of E. coli cell-wall growth.
      Title: RodZ modulates geometric localization of the bacterial actin MreB to regulate cell shape.
    3. The data suggest that RodZ promotes the assembly of geometrically-localized MreB polymers that lead to the growth of uniform E. coli cylinders.
      Title: MreB polymers and curvature localization are enhanced by RodZ and predict E. coli's cylindrical uniformity.
    4. Results suggest that MreB binding to the cytoplasmic domain of RodZ causes structural changes in the disordered periplasmic domain of RodZ; also found that the disordered domain of RodZ contributes to fine-tune rod shape in E. coli.
      Title: The periplasmic disordered domain of RodZ promotes its self-interaction in Escherichia coli.
    5. SecA cotranslationally recognizes the nascent chain of an inner membrane protein, RodZ, with high affinity and specificity and SecA is necessary and sufficient to direct the targeting and translocation of RodZ to the bacterial plasma membrane.
      Title: SecA mediates cotranslational targeting and translocation of an inner membrane protein.
    6. MreB is not recruited to the FtsZ ring in secA mutant cells, contributing to division arrest and cell filamentation.. Thus, when we reroute RodZ, MreB membrane-anchor, by fusing it to a SecA-independent integral membrane protein and overproducing it, MreB localization is restored and the defect in cell division is corrected.
      Title: The bacterial Sec system is required for the organization and function of the MreB cytoskeleton.
    7. The data indicate the cellular requirement of both FtsN and DedD for septation as well as RodZ for cell elongation to maintain the small rod morphology at temperatures near 8 degrees C.
      Title: A requirement for cell elongation protein RodZ and cell division proteins FtsN and DedD to maintain the small rod morphology of Escherichia coli at growth temperatures near 8°C.
    8. Data show that actin homolog MreB rotates because cytoplasmic MreB filaments are coupled to periplasmic cell wall synthesis through the transmembrane protein RodZ, which acts as a transmembrane linker.
      Title: RodZ links MreB to cell wall synthesis to mediate MreB rotation and robust morphogenesis.
    9. The discrete spatial distribution and dynamics of PspA effector in lateral membrane regions depend on MreB and RodZ.
      Title: Anionic lipids and the cytoskeletal proteins MreB and RodZ define the spatio-temporal distribution and function of membrane stress controller PspA in Escherichia coli.
    10. A mutation in the promoter region of zipA, a component of the divisome, suppresses the shape defect of RodZ-deficient cells.
      Title: A mutation in the promoter region of zipA, a component of the divisome, suppresses the shape defect of RodZ-deficient cells.
    Submit: New GeneRIF Correction See all GeneRIFs (13)

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within FtsZ-dependent cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in peptidoglycan biosynthetic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of cell shape IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of cell shape IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell shape NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    located_in plasma membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cytoskeleton protein RodZ

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2641831..2642844 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417011.1 cytoskeleton protein RodZ [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417011.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0AAN5UA55
      Conserved Domains (1) summary
      PRK10856
      Location:1 → 332
      PRK10856; cytoskeleton protein RodZ
    Nucleotide Protein
    Heading Accession and Version

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