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    ccmH holocytochrome c synthase CcmH component [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946623, updated on 17-Dec-2024

    Summary

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    Official Symbol
    ccmH
    Official Full Name
    holocytochrome c synthase CcmH component
    Primary source
    ECOCYC:EG12052
    Locus tag
    b2194
    See related
    ASAP:ABE-0007262
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2186; yejP
    Summary
    CcmH is a membrane protein component of the CcmEFGH holocytochrome c synthetase. [More information is available at EcoCyc: EG12052].
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    Genomic context

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    Sequence:
    NC_000913.3 (2291358..2292410, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene IS5 family transposase and trans-activator Neighboring gene DNA-binding transcriptional dual regulator NarP Neighboring gene thiol:disulfide oxidoreductase CcmG Neighboring gene holocytochrome c synthase CcmF component Neighboring gene periplasmic heme chaperone Neighboring gene cytochrome c maturation protein D Neighboring gene cytochrome c maturation protein C

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dispensable residues in the active site of the cytochrome c biogenesis protein CcmH. Robertson IB, et al. FEBS Lett, 2008 Sep 3. PMID 18687332
    2. Helix swapping leads to dimerization of the N-terminal domain of the c-type cytochrome maturation protein CcmH from Escherichia coli. Ahuja U, et al. FEBS Lett, 2008 Aug 6. PMID 18625227
    3. Biochemical properties and catalytic domain structure of the CcmH protein from Escherichia coli. Zheng XM, et al. Biochim Biophys Acta, 2012 Dec. PMID 22789558
    4. A variant System I for cytochrome c biogenesis in archaea and some bacteria has a novel CcmE and no CcmH. Allen JW, et al. FEBS Lett, 2006 Sep 4. PMID 16920107
    5. Functional characterization of the C-terminal domain of the cytochrome c maturation protein CcmE. Harvat EM, et al. J Biol Chem, 2005 Nov 4. PMID 16129669

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. mature CcmH is a periplasm-resident oxidoreductase anchored to the inner membrane by two transmembrane segments
      Title: Biochemical properties and catalytic domain structure of the CcmH protein from Escherichia coli.
    2. The active-site cysteines of E. coli CcmH, as well as R42, S54, R63, were replaced with alanine and the replacement effect on cytochrome c production was tested.
      Title: Dispensable residues in the active site of the cytochrome c biogenesis protein CcmH.
    3. CcmH forms a tightly interlinked dimer by swapping its N-terminal helix between two monomers.
      Title: Helix swapping leads to dimerization of the N-terminal domain of the c-type cytochrome maturation protein CcmH from Escherichia coli.
    4. Data show that a variant System I for cytochrome c biogenesis in archaea and some bacteria has a novel CcmE and no CcmH.
      Title: A variant System I for cytochrome c biogenesis in archaea and some bacteria has a novel CcmE and no CcmH.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-disulfide reductase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytochrome complex assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cytochrome complex assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cytochrome complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    holocytochrome c synthase CcmH component

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2291358..2292410 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416698.1 holocytochrome c synthase CcmH component [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416698.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A5N3D656, A0A6D0IAV7, A0A8T5ZUP0
      Conserved Domains (3) summary
      COG3088
      Location:1 → 133
      NrfF; Cytochrome c-type biogenesis protein CcmH/NrfF [Energy production and conversion, Posttranslational modification, protein turnover, chaperones]
      COG4235
      Location:136 → 350
      NrfG; Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones]
      sd00006
      Location:222 → 250
      TPR; TPR repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version

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