U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    atoS sensor histidine kinase AtoS [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 949011, updated on 3-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    atoS
    Official Full Name
    sensor histidine kinase AtoS
    Primary source
    ECOCYC:EG11667
    Locus tag
    b2219
    See related
    ASAP:ABE-0007341
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2212
    Summary
    AtoS belongs to the two component systems AtoS/AtoC that responds to growth in minimal media . [More information is available at EcoCyc: EG11667].
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Sequence:
    NC_000913.3 (2320043..2321869)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional activator RcsB Neighboring gene histidine kinase RcsC Neighboring gene DNA-binding transcriptional activator/ornithine decarboxylase inhibitor AtoC Neighboring gene acetyl-CoA:acetoacetyl-CoA transferase subunit alpha Neighboring gene acetyl-CoA:acetoacetyl-CoA transferase subunit beta Neighboring gene short chain fatty acid transporter

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Functional characterization of the histidine kinase of the E. coli two-component signal transduction system AtoS-AtoC. Filippou PS, et al. Biochim Biophys Acta, 2008 Sep. PMID 18534200
    2. The soul of an HMO. Larson E. Time, 1996 Jan 22. PMID 10153782
    3. Activation of the AtoSC two-component system in the absence of the AtoC N-terminal receiver domain in E. coli. Theodorou EC, et al. Amino Acids, 2011 Feb. PMID 20563612
    4. Extracellular Ca2+ transients affect poly-(R)-3-hydroxybutyrate regulation by the AtoS-AtoC system in Escherichia coli. Theodorou MC, et al. Biochem J, 2009 Feb 1. PMID 18855762
    5. Effect of histamine on the signal transduction of the AtoS-AtoC two component system and involvement in poly-(R)-3-hydroxybutyrate biosynthesis in Escherichia coli. Kyriakidis DA, et al. Amino Acids, 2008 Jun. PMID 18235991

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data indicate that the involvement of the AtoSC system in the fatty acids metabolic pathways interplay towards cPHB biosynthesis provides additional perceptions of AtoSC role on E. coli regulatory biochemical processes.
      Title: AtoSC two-component system is involved in cPHB biosynthesis through fatty acid metabolism in E. coli.
    2. AtoC N-terminal receiver domain regulated the biological activities of AtoSC.
      Title: Activation of the AtoSC two-component system in the absence of the AtoC N-terminal receiver domain in E. coli.
    3. Effect of histamine on the signal transduction of the AtoS-AtoC two component system and involvement in poly-(R)-3-hydroxybutyrate biosynthesis in Escherichia coli.(
      Title: Effect of histamine on the signal transduction of the AtoS-AtoC two component system and involvement in poly-(R)-3-hydroxybutyrate biosynthesis in Escherichia coli.
    4. AtoS is a membrane protein which can autophosphorylate & then transfer that phosphoryl group to AtoC. Gene products of atoS & atoC constitute a 2-component signal transduction system, with some unusual properties, involved in regulation of atoDAEB operon.
      Title: Phosphorylation activity of the response regulator of the two-component signal transduction system AtoS-AtoC in E. coli.
    5. These results indicate that the presence of both a functional AtoS-AtoC two-component signal transduction system and a functional atoDAEB operon is critical for the enhanced poly-(R)-3-hydroxybutyrate cPHB biosynthesis in E. coli.
      Title: Involvement of the AtoS-AtoC signal transduction system in poly-(R)-3-hydroxybutyrate biosynthesis in Escherichia coli.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphorelay sensor kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphorelay sensor kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein histidine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in phosphorelay signal transduction system IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to polyamine macromolecule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    sensor histidine kinase AtoS
    NP_416723.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2320043..2321869
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416723.1 sensor histidine kinase AtoS [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416723.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2H4TXE0, A0A3P5DQW9
      Conserved Domains (1) summary
      PRK11360
      Location:7 → 606
      PRK11360; two-component system sensor histidine kinase AtoS
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.